Lexvotene-S 0.5mg/ml Kolmar Korea solution for allergic rhinitis, sneezing, runny nose (30 packs x 10ml)

Dosage form Box of 30 packs x ml
Specifications Levocetirizine dihydrochloride

Ingredient

Thành phần cho 10ml

Composition information	Content
Levocetirizine dihydrochloride	5mg

Uses

Indications

Lexvotene - S Solution is indicated in the following cases:

Treatment of allergic cases such as seasonal allergic rhinitis, chronic heteritis g; Sneezing, runny nose, itchy nose, tears, red eyes; Chronic urticaria. Levocetirizine's antihistamine resistance has been clearly demonstrated on both humans and animals. In vitro and in vivo studies show that Levocetirizine works with receptors other than H1 and the drug is not linked to the H1 receptor in the brain.

Levocetirizine 5 mg dose of the skin -to -skin -to -skin -to -skin -to -skin -to -shot burning effect with a subcutaneous histamine injection with a lasting effect for at least 24 hours.

pharmacokinetic

absorption

Levocetirizine is quickly and widely absorbed by oral. The peak concentration in plasma is 0.9 hours after drinking. The peak concentration is 270 ng/ml and 308 ng/ml at a single dose and the dose repeats 5 mg. The absorption range depends on the dose and is not changed by food.

Distribution

There is no data that shows the drug distributed into the body as well as the drug passing through the brain barrier. In mice and dogs, the highest concentration in tissues is seen in the liver and kidneys, the lowest concentration in the central nervous system. 90% levocetirizine is connected to plasma proteins. Levocetirizine distribution is limited, the distribution volume is 0.4 l/kg.

Elimination

Levocetirizine's semi -discharged time in human plasma is 7.9 ± 1.9 hours. The total clearance is 0.63 ml/min/kg. Levocetirizine and metabolites are mainly eliminated in the urine, accounting for 85.4% of the dose. Elimination through fertilizer is only about 12.9% of the dose. Levocetirizine is eliminated by both glomerular and renal filter.

Before taking Lexvotene-S 0.5mg/ml Kolmar Korea solution for allergic rhinitis, sneezing, runny nose (30 packs x 10ml)

How to use

Lexvotene - S Solution is used orally, can be taken or not accompanied by food, drink once a day. Drinking time may vary to each patient.

Dosage

Adults and children aged 6 and over

oral 5 mg (equivalent to 10 ml of solution)/time.

Children under 6 years old

Do not use drugs for children under 6 years old.

Patients with renal failure

Creatinine clearance 30 - 49 ml/minute: 5 mg/time, every 2 days of use.

Creatinine clearance 10 - 30 ml/minute: 5 mg/time, every 3 days of use.

Creatinine clearance

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? There is no specialized treatment when overdose with levocetirizin occurs, it is necessary to use appropriate treatments to eliminate the drug. You can wash the intestines after using the overdose short time. Levocetirizin is not excluded by the separation method.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Lexvotene - S Solution, you may experience unwanted effects (ADR).

Some unwanted effects have been reported such as drowsiness, dry mouth , headache , fatigue, weakness, rhinitis, pharyngitis, insomnia, abdominal pain and migraine.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Lexvotene - S Solution Contraindications in the following cases:

Hypersensitivity to the ingredients or piperazine derivatives.

Severe renal failure with Clcr

Children under 6 years old.

Pregnant and lactating women.

Precautions when using

before taking levocetirizine, telling the doctor or pharmacist:

If you are allergic to levocetirizine, Cetirizine (Zyrtec), or any other drug.

The pharmaceuticals you are taking, including prescription and prescription drugs, vitamins, supplements and herbal products.

Your history if you have kidney disease.

The ability to drive and operate machinery

levocetirizine can cause drowsiness, especially when used with alcohol. Do not drive or operate machinery until you know how this medicine affects you.

Pregnancy

only used when really necessary.

Breastfeeding period

levocetirizine is expected to be excreted through breast milk, so use this medication in breastfeeding mothers is not recommended.

Medicinal interaction

levocetirizine may interact with antidepressants, anxiety, mental illnesses, or convulsions, ritonavir (Norvir, in Kaletra), sleeping pills, theophyline (bychron, theoLair).

Storage

Store in a dry place, temperatures below 30ºC, avoid moisture and light.

Other drugs

Disclaimer

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