Lidocaine injection solution 40mg/2ml Vinphaco anesthetic anesthesia (100 tubes x 2ml)

Dosage form Box of 100 tubes x 2ml
Specifications Lidocaine

Ingredient

Thành phần cho 2ml

Composition information	Content
Lidocaine	40mg

Uses

Indications

The drug is indicated in the following cases:

In -spot anesthesia before examination, endoscopy, technical equipment, or perform other procedures and to reduce pain symptoms in many diseases. Failure after myocardial infarction or while conducting technical operations of the heart such as heart surgery or cardiac catheterization. Lidocaine is a selective drug to treat ventricular extras in myocardial infarction, treat ventricular tachycardia and ventricular vibration. The anesthetic in the seals both generate and transmit nerve impulses by reducing the permeability of the nerve cell membrane with sodium ions, thus stabilizing the membrane and inhibiting the reducing, leading to a decrease in the spread of active voltage and then a nerve impulse transmission block. Lidocaine is currently the most widely used, faster anesthesia, stronger and longer acting time than the same process. Lidocaine is chosen for people who are sensitive to esters. Lidocaine is effective in all cases that need an anesthetic with average effect.

Lidocaine is also an anti -arrhythmic drug, thanks to the Na+channel blocker, which is ranked 1B, is used intravenously to treat ventricular arrhythmia. Lidocaine reduces the risk of ventricular vibration in suspected people with myocardial infarction. However, the survival rate does not increase but may be reduced. When using lidocaine without careful diagnosis methods can increase the risk of heart block, or congestive heart failure. Therefore, lidocaine is not used for widely treatment for all patients, unless there is adequate diagnosis. Lidocaine blocks Na+ open channels and non -activity channels of the heart. The recovery is then fast, so the lidocaine works on the reducing cardiac tissue (ischemic) stronger than the heart without ischemic.

pharmacokinetics

After intravenous injection, associated drugs and plasma proteins are about 60% - 80%.

Lidocaine effect depends on maintenance of plasma treatment concentrations in the center.

Before taking Lidocaine injection solution 40mg/2ml Vinphaco anesthetic anesthesia (100 tubes x 2ml)

How to use

intramuscularly, intravenous injection, intravenous injection, subcutaneous injection.

There is no special requirement on drug treatment after use.

Dosage

Anesthesia

Inject directly into the lidocaine hydrochloride injection tissue; When not adrenalin adds: lidocaine dose up to 4.5 mg/kg; When adrenalin adds: This dose may be added to one third (7 mg/kg).

Anesthesia

subcutaneous injection of Lidocaine hydrochloride solution with the same concentration and dosage as anesthesia.

Neurotic anesthesia

Inject lidocaine solution in or near the nerve or peripheral nerve puppet will have a wider anesthetic effect than the above -mentioned techniques.

Excent ventricular treatment

To avoid the insecurity associated with the distribution, use the dose mode 3 - 4 mg/kg for 20-30 minutes by direct injection into the vein, for example, use the initial dose of 100 mg, followed by a dose of 50 mg, every 8 minutes for 3 times; It may then be maintained with stable plasma concentrations by infusion of 1 - 4 mg/min, to replace the excluded drug due to metabolism in the liver. The time of reaching lidocaine concentration in a stable state is 8 - 10 hours.

In case of necessity, use lidocaine hydrochloride to treat acute arrhythmia, can be intramuscularly in the Delta muscle at a dose of 300 mg, repeated if necessary after 60 - 90 minutes.

Heart failure and liver disease

Must reduce the total initial loading dose and the injection speed to maintain, as well as when the infusion lasts for a long time, the starting dose of 0.75 mg/minute or 10 micrograms/kg/minute; maximum 1.5 mg/minute or 20 micrograms/kg/minute. Needs to measure plasma lidocaine levels and adjust the dose to ensure plasma concentration remains within the scope of treatment (1.5 - 5 micrograms/ml) to reduce the toxicity of the drug.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Overdose symptoms include: sedation, confusion, coma, convulsions, respiratory arrest and toxic heart (sinus stops, atrial - ventricular block, heart failure, and reducing blood pressure); Normal QRS and QT intervals, although it may last for severe overdose. Other effects include dizziness, paresthesia, tremor, loss of air conditioning, and digestive disorders.

Treatment is only supported by common measures (infusion, patients in appropriate posture, taking hypertension, anti -arrhythmic drugs, anti -convulsive drugs); Sodium bicarbonate can recover long -term QRS, bradycardia and lower blood pressure. Hematopause increases lidocaine elimination.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using lidocaine 40 mg/2 ml , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Cardiovascular: lower blood pressure.

Central nerve: headache when changing posture.

Other: Cold tremor.

Uncommon, 1/1000

Cardiovascular: heart, arrhythmia, cardiovascular, cardiac arrest.

Respiratory: Difficulty breathing, decline or respiratory arrest.

Central nerve: Sleeping, coma, excitement, whirling, convulsions, anxiety, refreshment, hallucinations.

Skin: itching, rash, skin edema, numbness around the lips and tip of the tongue.

Digestive: Nausea, vomiting.

Neurosurgery and bone: Perception.

Eyes: blurred vision.

Instructions on how to handle ADR

For systemic reactions due to excessive absorption: maintain ventilation, give 100% oxygen and perform respiration support or cancel only, when needed. In some patients, the internal intubation is needed. An anti -sedative, anti -convulsions benzodiazepin (remember to be inexplicable benzodiazepine can cause respiratory and circulatory inhibitors, especially when injected quickly), until the patient is completely awake (about 1 hour).

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

40 mg/2 ml lidocaine drugs in the following cases:

Too hypersensitivity to lidocaine or with anesthetic amids or with any ingredients of the drug.

Patients with Adams - Stokes syndrome, Wolf - Parkinson syndrome - White, or sinus - atrial, atrial - ventricular disorders at all levels, severe myocardial failure, or in ventricular block (when there is no rhythmic device).

Porphyrin metabolic disorders.

Prisable when using

do not use lidocaine preparations containing preservatives to anesthetize spinal numbness, epidural anesthesia, or the same compartment.

Use very carefully for people with liver disease, heart failure, severe lack of blood oxygen, severe respiratory failure, reduced blood volume or shock, incomplete heart or heartbeat, pitch and atrial fibrillation.

Use cautious in serious or depressed people, because it is prone to body poisoning with lidocaine.

Do not inject anesthetic into inflamed or bacterial tissues and do not put in the urethra injured because in such conditions, the drug will be absorbed quickly and causes systemic reactions instead of local reaction.

The ability to drive and operate machinery

When anesthetic on the outpatient numbness in areas of the body related to driving or operating machinery, patients should avoid these activities until the function of these areas is completely restored.

Pregnancy

Lidocaine has been used in surgery for pregnant women without notice of harmful effects on the mother and fetus.

Breastfeeding period

Lidocaine is distributed in breast milk in very small amounts, so there is no risk of harmful effects on breastfeeding.

Drug interaction

Adrenalin in collaboration with Lidocaine reduces the absorption and toxicity, thus prolonging the effect time of lidocaine.

cimetidine can inhibit lidocaine metabolism in the liver, leading to an increased risk of lidocaine poisoning. Cyproteron, Eravirin, Peginterferon Alfa - 2B, Tocilizumab.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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