Lincomycin 500mg Domesco Treatment Treatment of infections (20 blisters x 10 tablets)

Dosage form Box of 20 blisters x 10 tablets
Specifications Lincomycin

Ingredient

Composition information	Content
Lincomycin	500mg

Uses

indications

Lincomycin 500 mg drug is indicated in the following cases:

Severe infections caused by sensitive bacteria, especially Staphylococcus, Streptococcus, Pneumococcus in patients with allergies to penicillin such as liver abscess; Bone infection caused by staphylococcus; Vaginal infections, inflammation in the uterus, pelvic inflammatory disease; secondary peritonitis; lung abscess; Blood infection; Piti pimples and anaerobic ulcer. Streptomyces tedulnensis, other lincolnensis species or by another method.

Lincomycin has anti -bacterial effects like Clindamycin, but less effective. The drug is mainly gram -like bacteria and has a wide antibacterial spectrum for anaerobic bacteria.

Mechanism of action

Lincomycin, as well as other lincosamids attached to the mini of the part of the bacterial ribosom like macrolids like erythromycin and hinder the first phase of protein synthesis. The main effect of Lincomycin is bacteria, but at high concentrations can kill slowly for sensitive strains.

Effect spectrum

The drug is effective for many Gram -positive bacteria, including Staphylococcus, Streptococcus, Pneumococcus, Bacillus Anthracis, Corynebacterium diphtherine. However, it does not work with Enterococcus. Lincomycin has a broad spectrum for anaerobic bacteria. Sensitive Gram -positive anaerobic bacteria include eubacterium, propionibacterium, peptococcus, peptostreptococcus and multiple strains of Clostridium perfringens and CL. Tetani.

with high doses, Lincomycin works for Gram -negative anaerobic bacteria, including Bacteroides spp. The drug also has a few effects on unicellular animals, so it has been tried in the treatment of pneumocystiscarini pneumonia and Toxoplasma infection.

The minimum concentration of Lincomycin inhibitors for the most sensitive bacteria strains range from 0.05 - 2 micrograms/ml.

Drug resistance

Slow and sequential drug resistance. There is cross resistance with clindamycin. The majority of Gram -negative bacteria, such as Enterobacteriaceae, has Lincomycin resistant nature, but some other strains, often sensitive can become resistant. The anti -drug mechanism, like for erythromycin, includes methylation of the position mounted on ribosom, the chromosomal mutation of ribosom protein and in a few staphylococcus astrapia, enzyme loss due to adenyltransferase via plasmid intermediaries. Methylation of ribosom leads to cross -resistance between Lincomycin and Clindamycin.

Dynamic pharmacokinetics

oral 1 dose of 500 mg lincomycin, about 20-30% of the dose is absorbed through the gastrointestinal tract and achieved plasma peak concentration from 2 - 7 micrograms/ml for 2-4 hours. Food sharply reduces the speed and level of absorption.

Lincomycin's waste time is about 5 hours. Lincomycin is distributed into tissues, including bone tissue and fluid, but less into the cerebrospinal fluid, although it can be distributed better when the meninges are inflamed. The drug diffuses through the placenta and is found 0.5 - 2.4 micrograms/ml Lincomycin in breast milk. Lincomycin does not eliminate much from blood through the virtue.

Lincomycin is partially durable in the liver and is exported through urine and feces, in the form of unchanged and chemical form.

Before taking Lincomycin 500mg Domesco Treatment Treatment of infections (20 blisters x 10 tablets)

How to use

oral medication.

Drink away from meals, at least 1 hour before eating or 2 hours after eating.

Dosage

Adults: 1 tablet/time x 3 times/day; If the disease is very serious: 2 capsules/time x 3 times/day.

This drug is not suitable for children.

For people with severe renal failure: reducing 25 - 30% of normal dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Handling: gastric lavage, supportive treatment. Hematopopare and peritoneal cessation do not significantly affect the blood levelcin level in the blood.

Notice immediately to the doctor if the symptoms are overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Lincomycin 500 mg, you may experience unwanted effects (ADR).

The most common is in the digestive tract, mainly diarrhea.

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea, sometimes due to too much development of Clostridium difficile.

Uncommon, 1/1000

Skin: urticaria, rash.

Rare, ADR

Body: Anaphylaxis.

Blood: neutrophils (recovery). digestive: fake colitis, esophagitis.

Liver: increased liver enzymes (recovered), such as increased transaminase.

Instructions on how to handle ADR

The severe diarrhea may be associated with fake colitis caused by toxins released from excessive development. This can happen after treatment with Lincomycin. The elderly and bad physical condition are at high risk. Excessive development of clostridium difficile with metronidazole or vancomycin.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Lincomycin 500 mg contraindicated drug in the following cases:

Hypersensitivity to Lincomycin or drugs with Lincosamid family, and any ingredients of the drug.

Be cautious when using

when used for people with gastrointestinal diseases, especially people with a history of colitis. Elderly and female people may be susceptible to severe diarrhea or fake colitis.

People with liver failure, severe renal failure must adjust the dose accordingly.

Patients with long -term treatment with Lincomycin and with children must monitor. Periodic liver function and blood formula.

Lincomycin has a neurological -muscle blocker, so it should be cautious when using other drugs with similar effects (anti -diarrhea drugs such as loopamid, opium to worsen colitis due to slow secretion of toxins).

Be cautious when used with patients with a history of asthma or serious allergy.

The ability to drive and operate machines

drugs do not affect the driver and operate machinery.

Pregnancy

There has been no Lincomycin notice that causes birth defects. The drug passes through the placenta and reaches about 25% of the mother serum concentration in the umbilical cord. Only used for pregnant women when really necessary.

The period of breastfeeding

lincomycin is secreted in breast milk to the point where it is likely to adversely affect breastfeeding. Need to avoid breastfeeding while being treated with Lincomycin.

Drug interaction

Lincomycin does not affect the pharmacokinetics of Gentamicin, but the safety has not been assessed when combining those two drugs.

anti -diarrhea drugs containing kaolin reduces Lincomycin absorption, should take Lincomycin 2 hours after using kaolin.

Effects of oral contraceptives can be inhibited or reduced due to normal bacterial disorders in the intestine, causing gut -liver blocking.

Be cautious when coordinating with neurological - muscle blockers, because Lincomycin is similar.

Food and sodium cyclamate (sweeteners): Shut down the absorption of Lincomycin.

lincomycin and erythromycin have antagonistic antagonistic effects. It is not clear the importance of this interaction clinically, so it is best not to combine these two antibiotics.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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