Lincomycin Kabi injection is severe treatment (50 pipes x 2ml)
Dosage form Box of 5 blisters x 10 tubes x 2ml
Specifications Lincomycin
Ingredient
Thành phần cho 2ml
| Composition information | Content |
| Lincomycin | 600mg |
Uses
Indications
Lincomycin Kabi drug is indicated for treatment of severe infections, due to sensitive bacteria caused in the following positions:
Mechanism of action
Lincomycin as well as other lincosamids attached to the 50s of the bacterial ribosom like macrolids like erythromycin and hinder the first phase of protein synthesis. The main effect of Lincomycin is bacteria, but at high concentrations can kill slowly for sensitive strains.
antibacterial spectrum
Moderate sensitive and medium sensitive strains with antibiotic resistance strains: S 8 mg/l.
The incompatible drug ratio of some species may vary by geography and time. Therefore, information on drug resistance ratio is very useful, especially when treating severe infections. These data may only allow the sensitive ability of a bacterial strain to Lincomycin.
bacteria
Frequency of drug resistance in France (> 10%) (maximum value)
Gram (+) aerobic bacteria
corynebacterium diphheriae.
Enterococcus fast.
50 - 70%
erysipelothrix.
Staphylococcus meti-S.
staphylococcus meti-r *.
70 - 80%
streptococcus b.
Streptococcus Ungroupable.
30 - 40%
streptococcus pneumoniae. 35 - 70%
streptococcus pyogenes. 16 - 31%
campylobacter.
anaerobic bacteria
5 - 30%
capnocytophaga.
25 - 35%
Clostridium perfringens.
eubacterium.
fusobacterium.
20 - 30%
porphyromonas.
Prevotella.
5 - 15%
Veillonella. chlamydia trachomatis leptospira. mycoplasma hominis. mycoplasma pneumoniae. Gram (+) aerobic bacteria corynebacterium jeikeium. Bowel bacteria (except for Enterococcus Faecium) listeria. nocardia asteroids. rhodococcus Equi. Gram aerobic bacteria (-) Gram-shaped bacteria (-), non-fermentation (acinetobacter, pseudomonas, ...) branhamella catrhalis. bacteria in the intestine haemophilus. legionella. neisseria. Pasteurella. anaerobic bacteria Clostridium dificile. Other species bacteria that cause tuberculosis, leprosy ureaplasma ureaticum. absorption After a 600 mg intramuscular dose, Lincomycin achieved maximum plasma concentrations after 1 to 2 hours. The maximum concentration changes in the range of 8.0 to 18.0 mcg/ml. Distribution The average selling time for the drug is from 4 to 6 hours. Lincomycin is widely distributed throughout the body, and is not clearly concentrated in any organ. About 70% of the drug is attached to plasma proteins. Low cerebrospinal fluid concentration. Lincomycin passes through the placenta, the drug is excreted into breast milk with a concentration of 0.5 to 2.4 mcg/ml and has a large diffusion into the bone tissue. Metabolism Lincomycin is metabolized in the liver. Elimination Lincomycin is eliminated in urine and bile. The drug is also detected in stool. Elimination through bile plays a very important role and the concentration reaches 2 to 6 times higher than the concentration of drugs in the blood. Hepatic failure reduces drug elimination. Extraction through the kidneys vary depending on the usage: 4 - 14% of the drug is excreted through stool when used injected. pharmacokinetic
Before taking Lincomycin Kabi injection is severe treatment (50 pipes x 2ml)
How to use
Lincomycin Kabi medicine uses intravenous line, how to use in the following table:
minimum doses
Minimum dilution volume
Time of transmission
600 mg
100 ml
1 hour
1 g
100 ml
1 hour
2 g
200 ml
2 hours
3 g 300 ml 3 hours
4 g 400 ml
4 hours
Adults
600 to 1800 mg/24 hours.
Children over 30 days old
10 to 20 mg/kg/24 hours.
intravenous infusion (no direct intravenous)
Adults
600 mg (2 ml) x 2-3 times/day, slow speed transmission with isothermic dilution solution of glucose or sodium chloride. Increase the dose depending on the nature and severity of the infection.
Children over 30 days old
Depending on the nature and severity of the infection, the dose of 10 to 20 mg/kg/day. The total daily dose is divided into 2 to 3 times, slow intravenous infusion with isothermic dilution solution or sodium chloride.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when overdose?
Overdose
There may be digestive reactions including abdominal pain, nausea, vomiting and diarrhea. In addition, there have been reports of fatigue, dizziness, delirium, lower blood pressure, shortness of breath, abnormalities of tongue lips, drowsiness, mild itching or fleeting.
There has been a report on heart -lung circulation when high -dose injection is not diluted. These adverse events will not occur if the drug is injected slowly and diluted.
Handling
There is no specific antidote, need symptom treatment and reasonable treatment.
cannot remove lincycin from plasma by hemolysis and peritoneal juris.
What to do when forgetting 1 dose?
Side Effects
When using Lincomycin Kabi, you may experience unwanted effects (ADR).
Common, ADR> 1/100
Instructions on how to handle ADR
When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.
Warnings
Contraindicated
Lincomycin Kabi drug is contraindicated in the following cases:
Caution when using
Warnings
diarrhea caused by Clostridium difficile has been reported to most antibiotics, including Lincomycin. The degree of severity may vary from mild diarrhea to colitis leading to death. The treatment with antibiotics changes the bacterial system leading to overcurrent growth C. Difficile.
C. Difficile produces toxins A and B leading to diarrhea. C. Difficile strains produce strong toxins that increase the incidence of disease and mortality due to these infections that can be resistant to antibiotics and are required to remove the colon.
It is necessary to take into account the ability to diarrhea caused by Clostridium difficile in all patients with diarrhea after antibiotic use, especially paying attention to the history of the disease, due to diarrhea can occur 2 months after antibiotic use.
severe diarrhea occurs even after a few weeks of stopping treatment due to antibiotic use. Do not use drugs that cause stagnation. If diarrhea, it is necessary to stop treating antibiotics and if severe diarrhea requires hospitalization. Recommendation for endoscopy.
Cases of diarrhea with mild mucosal damage can recover by stopping treatment. Average to severe cases, along with symptomatic treatment under strict monitoring, oral dosage adjustment (adults: 125 to 500 mg 4 times/day for 5 to 10 days) or when not using Metronidazol (750 mg x 2 times/day for 5 to 10 days).
Using antibiotics can increase the development of non -sensitive organisms, especially yeast.
Prevention when using
Do not be direct intravenous injection.
Not used when colitis.
Use carefully for patients with a history of asthma or allergies.
When treated for prolonged treatment, the number of blood cells must be monitored, liver function tests and kidney function.
In patients with liver or kidney failure, Lincomycin's waste sale time increases. Therefore, the recommendation of adjusting the dose according to the drug concentration in plasma.
The drug containing Benzyl alcohol is a preservative related to a serious adverse reaction including "breathing syndrome" and death in the group of pediatric patients. Although at the usual treatment, the amount of alcohol benzyl alcohol is significantly lower than the dose that causes "breathing syndrome". The minimum dosage of the toxicity of Benzyl alcohol. The risk of toxicity of benzyl alcohol depends on the dose of alcohol benzyl alcohol and the liver detoxification ability. Premature babies and infants may be low at risk of higher toxicity. The drug can cause toxic and allergic reactions to children and children under 3 years old.
The ability to drive and operate machinery
The drug has no adverse effects on the ability to drive and operate machinery.
Pregnancy
for safety, best not to use Lincomycin for pregnant women. In fact, although there are clinical data on ensuring safety when using Lincomycin for pregnant women, these data are limited in quantity and data on animals is not enough to conclude.
Benzyl alcohol excipients can pass through the placenta fence.
Breastfeeding period
Based on the profile of the safety of the drug, contraindicated use Lincomycin for breastfeeding women.
Medicinal interaction
Interactions lead to contraindications for simultaneous use
erythromycin: Do not combine drugs with erythromycin to avoid antibody -effect.
Interactions should be cautious when coordinating
Curare derivatives: Pay attention to the ability to cause muscle relaxation of curare when using antibiotics before, during or after muscle relaxants. Monitor the level of muscle relaxation at the end of the anesthesia.
Interactive attention should be noted when coordinated
Interaction with subclinical tests.
Lincomycin may affect the testing test of alkaline phosphatase concentration in plasma. The collected value may increase higher than the actual value.
Inr value imbalance
There have been many effective oral anticoagulant reports in patients using antibiotics simultaneously. In case of severe inflammation or infection, age and general health condition may be risk factors. In these cases, it is difficult to distinguish between infections and is difficult to treat when there is an imbalance inr. However, some antibiotic groups are more likely to occur more interactive including fluoroquinolon, macrolid, cyclin, cotrimoxazol, and some cephalosporins.
Cavalry
Medicines with chemical - physical with Novobobiocin, Kanamycin and Phenytoin.
Storage
The temperature does not exceed 30 ° C, avoiding light.
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