Lincomycin medicine 500mg Vidipha treats infection with ear, nose and throat, bronchial, lungs (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Lincomycin

Ingredient

Composition information	Content
Lincomycin	500mg

Uses

Indications

Lincomycin 500mg drug is indicated for treatment of severe bacterial infections due to sensitive bacteria , including:

ears, nose and throat.

Pharmacy

Mechanism of action

lincomycin as well as other lincosamids attached to the 50S target of ribosom bacteria like macrolids like erythromycin and hinder the first phase of protein synthesis. The main effect of Lincomycin is bacteria, but at high concentrations can kill slowly for sensitive strains.

Lincomycin is an antibiotic of Lincosamid obtained by streptomyces lincolnensis culture, other lincolnensis species or by another method.

Lincomycin has the same structure as clindamycin, anti -bacterial effects such as clindamycin , but less effective. The drug is mainly gramy -positive and wide antibacterial streets for anaerobic bacteria .

Effect spectrum

Lincomycin 500mg drug is effective for many Gram -positive bacteria, including Staphylococcus, Streptococcus, Pneumococcus, Bacillus Anthracis, Corynebacterium Diphtheriae. However, it does not work with Enterococcus.

Most gram -prone bacteria, such as Enterobacteriaceae, are resistant to Lincomycin, unlike erythromycin, Neisseria gonorrhoeeae, N.Meningitidis and Haemophilus Influenzae are often resistant to Lincomycin. Lincomycin has a broad spectrum for anaerobic bacteria. Sensitive Gram -positive anaerobic bacteria include eubacterium, propionibacterium, peptococcus, peptostreptococcus and multiple strains of clostridium perfringens and clostridium tetani.

with high doses, Lincomycin works for cavalry bacteria when gram negative, including Bacteroides spp. The drug also has a few effects on unicellular organisms, so it has been tried in the treatment of pneumonia caused by Pneumocystis Carinii and Toxoplasma infection. The minimum inhibitory concentration of Lincomycin for the most sensitive bacteria strains is from 0.05 - 2microgam/ml.

Drug resistance

Most gram -negative bacteria, like Enterobacteriaceae, has Lincomycin resistant, but some other strains, often sensitive can become resistant. The anti -drug mechanism, like for erythromycin, includes methylation of the position mounted on ribosom, the chromosomal mutation of the protein of ribosom and in a few staphylococcus a staph, the loss of enzyme activity due to denyltransferase via plasmid intermediaries.

Methylation of ribosom leads to cross -resistance between Lincomycin and Clindamycin. Sometimes there is partial cross resistance to macrolid antibiotics (erythromycin). This phenomenon may be due to the dispute between erythromycin and lincomycin on the mounting location of ribosom.

pharmacokinetic

absorption

Take 1 dose of Lincomycin 500mg, about 20-30% of the dose absorbed through the gastrointestinal tract and achieve plasma peak concentration from 2 - 3microgam/ml for 2-4 hours. Food sharply reduces the speed and level of drug absorption.

Distribution

Lincomycin is distributed into tissues, including bone tissue and fluid. The drug is less on the cerebrospinal fluid, so it is not used in the treatment of meningitis. The drug diffuses through the placenta and allocated into breast milk with a concentration of 0.5 - 2.4microgam/ml.

Metabolism

Lincomycin is partially inactive in the liver.

Elimination

Lincomycin's plasma waste time is about 5 hours in people with normal kidney function, but can double in people with liver failure and last up to 3 times in severe kidney failure. Exported in urine and feces, in the form of unchanged and metabolic form.

Before taking Lincomycin medicine 500mg Vidipha treats infection with ear, nose and throat, bronchial, lungs (10 blisters x 10 tablets)

How to use

Used by oral.

Drink away from meals, at least 1-2 hours before or after eating.

Dosage

Adults

Take 3-4 tablets/day depending on the severity of the infection.

Children over 1 month of age

Use other appropriate forms of preparation, drink 30 - 60mg/kg body weight depending on the severity of the infection.

Dosage for people with kidney failure

Dosage reduction for people with severe renal failure, appropriate dose equal to 25-30% of normal dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?
abdominal pain , nausea, vomiting and diarrhea . In addition, it may occur transient and lightweight of fatigue, dizziness. Hemorrhage drops, shortness of breath, abnormalities around the mouth, drowsiness, itch have also been reported.
Handling
In case of an overdose, it is recommended to immediately go to the nearest medical facility for medical staff to take timely measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used twice as doses of Lincomycin 500mg specified.

Side Effects

When using Lincomycin 500mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea, sometimes due to too much development of Clostridium difficile.

Uncommon, 1/1000

Skin: urticaria, rash.

Rare: 1/10,000

Body: Anaphylaxis.

Blood: neutrophils (recovery). digestive: fake colitis, esophagitis .

liver: increased liver enzyme (recovery), such as increased transaminase.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Lincomycin 500mg contraindicated in case of hypersensitivity to Lincomycin or with the same medications as Lincomycin or with any ingredients of the drug.

Precautions when using

must be cautious when used for people with gastrointestinal diseases, especially people with a history of colitis. Elderly and female patients may be susceptible to severe diarrhea or fake colitis.

Be cautious for people with allergies, people with liver failure or severe kidney failure.

For these people, they need to adjust the dose accordingly. For patients with long -term treatment with Lincomycin and for children, they need to periodically monitor liver and hematological function.

Lincomycin has a neurological -muscle blocker, so be careful when used with other drugs with similar effects (anti -diarrhea drugs such as loopamid, opium to worsen colitis due to slow secretion of toxins).

Safety and effectiveness of Lincomycin for children under 1 month of age has not been determined.

The ability to drive and operate machinery

There is no document.

Pregnancy

The drug passes through the placenta and reaches about 25% of the mother's serum concentration in the umbilical cord. There has been no complete control of drug use for pregnant people, Lincomycin should only be used for pregnant women when necessary.

Breastfeeding period

Lincomycin is secreted in breast milk, contraindicated for use for nursing women.

Drug interaction

Aminoglycosid: Lincomycin does not affect the pharmacokinetics of Gentamycin, but the safety has not been assessed when combining those two drugs.

Kaolin: anti -diarrhea drugs containing kaolin reduces Lincomycin absorption. To avoid this, give Lincomycin 2 hours after using Kaolin.

Theophylin: Lincomycin does not interact with theophylin.

Oral contraceptives: The effect of oral contraceptives can be inhibited or reduced due to bacterial disorders only normal in the intestine, causing gut -liver cycle.

Neurological - muscle blockers: Be cautious when coordinating with Lincomycin, because Lincomycin has the same property.

erythromycin: Due to the antagonistic antagonist between erythromycin and lincomycin, it is not coordinated with those 2.

Food and sodium cyclamate (sweeteners): greatly reducing the absorption of Lincomycin (to 2/3).

Storage

Store in a dry place, the temperature does not exceed 30 ° C, avoiding light.

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