Lipagim 300 medicine for lipoprotein disorders (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Fenofibrat

Ingredient

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Composition information	Content
Fenofibrat	300mg

Uses

indications

Lipagim drugs indicated the treatment of blood lipoprotein disorders of IIA, IIB, III, IV and V, coordinated diet.

Pharmacological

fenofibrat, derivative of fibric acid, is a blood lipid medication. The liver cholesterol biosynthesis inhibits the liver, reduces the plots (Lipoprotein very low density VLDL and Lipoprotein low density LDL), increasing the production of high density lipoprotein (HDL), and reducing blood triglycerides. Therefore, significantly improving cholesterol distribution in plasma.

Fenofibrat can reduce 20-25% of total cholesterol and 40-50% triglycerides in the blood. Fenofibrat treatment needs to be continuous.

Dynamic pharmacokinetics

absorption

Fenofibrat is absorbed in the gastrointestinal tract with food. Absorbing drugs is greatly reduced if taken after fasting overnight. The drug quickly hydrolyses into fenofibric acid that is active, which is highly attached to plasma albumin and can push vitamin K anti -vitamin drugs out of the mounting position. The maximum concentration is achieved after taking 5 hours.

Semi -cancellation time: about 20 hours but this time increases a lot in people with kidney disease and fenofibric acid accumulated significantly in people with kidney failure daily.

metabolism and elimination

Fenofibric acid eliminates mainly in urine (70% within 24 hours, 88% within 6 days), mainly in the form of glucuronic complex, in addition to fenofibric acid in the form of reducing and its glucuronic complex.

There is no phenomenon of accumulation of drugs and fenofibric acid is not eliminated when dunging.

There is no serious thing when stopping fibrat, even after long -term treatment and sudden removal.

Before taking Lipagim 300 medicine for lipoprotein disorders (3 blisters x 10 tablets)

How to use

Lipagim tablets for oral oral tablets, must take medicine with meals and combine with lipid restrictions.

Dosage

recommended dose:

10 -year -old children: The maximum dose of recommended is 5 mg/kg/day. Need to study carefully to determine the exact cause of hyperlipidemia in children. Treatment can be combined with a strictly controlled diet within 3 months.

Adults: 300 mg/day. The initial dose is usually 200 mg/day. If the whole blood cholesterol is still higher than 4 g/l, the dose can be increased to 300 mg/day. It is necessary to maintain the initial dose until blood cholesterol returns to normal. Blood cholesterol must be checked every 3 months. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose?

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Lipagim often has unwanted effects (ADR).

Common, ADR> 1/100:

Digestive: digestive disorders, epigastric area, nausea, bloating, mild diarrhea.

liver: Biliary tract stones

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Lipagim drugs contraindicated in the following cases:

Severe renal failure.

Severe liver dysfunction.

Be cautious when using

necessarily explore the liver and kidney function of the patient before starting to use Fibrat.

In patients with anticoagulant drugs: When starting to use fibrat, it is necessary to reduce the anticoagulant dose to only 1/3 of the old dose and adjust if necessary. Need to monitor more frequent amount of blood prothrombin. Adjust the anticoagulant dose during use and after 8 -day Fibrat.

Armor weakness can be a factor that increases the likelihood of side effects in muscle.

Need to measure transaminase every 3 months, in the first 12 months of taking the drug.

Must suspend drugs if sgpt (ALT)> 100 international units.

Do not combine fenofibrat with drugs that have a toxic effect with the liver.

Complications are prone to occurrence in patients with hepatomal stasis or gallstones.

If after a few months of taking the drug (3-6 months) and the amount of lipid in the blood changes is not significant, it is necessary to consider other therapy (additional or other).

Do not use 300 mg tablets for children; Using only tablets with this content for patients need a dose of 300 mg fenofibrat/day.

The effect of driving and operating machinery

has not seen the drug that affects the ability to drive and operate machinery.

Drug interaction

Use a combination of HMG inhibitors of Coa Reductase (for example: Pravastatin, Simvastatin, Fluvastatin) and Fibrat will significantly increase the risk of muscle damage and acute pancreatitis.

Combining fibrat with cislosporin increases the risk of muscle damage.

Fenofibrat increases the effects of anticoagulant oral medications, which increases the risk of bleeding due to pushing these drugs out of the position attached to plasma proteins. Need to monitor prothrombin more often and adjust the anticoagulant dose during fenofibrat treatment and after 8 -day stop stop.

Do not use a combination of poison with liver (Mao inhibitors, Perhexilin Maleat ...) with fenofibrat.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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