Lipcor 50 DHG Pharma tablets treat hypertension (3 blisters x 10 tablets)

Losartan is the first substance of the new anti -hypertension drug group, which is a receptor antagonist (Type AT1) Angiotensin II.

Losartan and the main metabolites have a clogged and aldosteron secretion of angiotensin II by preventing Angiotensin II selectively, not attaching to the AT1 receptor in many tissues (for example, blood vessel muscles, adrenal glands). Both Losartan and the main active metabolites do not show the local dominant effect in the AT1 receptor and have a much larger AT1 receptor affinity (about 1,000 times) than the AT2 receptor. Losartan is a competitive, reversible inhibitor of the AT1 receptor. The metabolites have the activity of drugs 10 to 40 times stronger than Losartan. Angiotensin II antagonists also have hemodynamic effects such as Angiotensin (ACE) enzyme inhibitors, but there is no unwanted effect of the common ACE inhibitors are dry cough.

pharmacokinetics

After drinking, Losartan absorbs well and initially metabolized through the liver thanks to the cytochrom P450 enzymes. Losartan's bioavailability is approximately 33%. About 14% of losartan dose taken into active metabolites, this substance is mostly opposing the Angiotensin II receptor resistance. Losartan waste sale time is about 2 hours, and of metabolites about 6-9 hours. The average peak concentration of Losartan reaches within 1 hour, and of the metabolites with activity within 3-4 hours.

both Losartan and active metabolites are highly linked to plasma proteins, mainly albumin and they do not pass the blood -brain barrier. In patients with mild to medium cirrhosis, the area under the curve (AUC) of Losartan and of the metabolites has a higher activity, corresponding, 5 times and 2 times higher than in patients with normal liver.

Children from 6 years old to 18 years old:

Dose reduction or stopping when there are unwanted effects.

Notify the doctor with unwanted effects when using the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Hypersensitivity: Patients with a history of angioedema (swelling of the face, lips, throat, tongue) should be closely monitored.

Hypotension and water balance disorders, electrolytes: When starting treatment or when increasing the dose may occur in humans of sodium loss in the blood due to diuretics, diarrhea, vomiting.

Electrolyte imbalance: Common in patients with renal failure, with or without diabetes.

Patients with liver failure: Low doses should be used for patients with a history of liver failure. Do not recommend using Losartan in case of severe liver failure patients.

Patients with kidney stenosis on both sides or one side, only one kidney has a high risk of unwanted effects (increased creatinine and blood urea) and should be closely monitored in treatment.

Inexperienced use of medication for kidney transplant patients.

Patient Aldosteron will not respond to the drug impact through the inhibition of the renin-ankiotensin system. Therefore, the use of Losartan is not recommended.

Excessive hypoglycemia may occur in patients with myocardial orchemic anemia, which can cause myocardial infarction or stroke.

Inexperienced in using Losartan for patients with heart failure and severe renal failure, patients with severe heart failure (NYHA IV) as well as patients with heart failure and arrhythmia threatening life. Therefore, Losartan should be used carefully in these patients. The combination of Losartan with beta-blocker should also be used cautiously.

Like other vasodilators, Losartan should be used with caution for patients with aortic stenosis, mitral stenosis or obstructive myocardial disease.

Lactose -containing drugs, patients with rare genetic problems galactose intolerance, lactase deficiency, glucose metabolic disorders - galactose should not use this product.

Use drugs for pregnant and lactating women

do not recommend using Losartan for the first three months of pregnancy. Contraindications to use Losartan in the middle and last three months of pregnancy.

Contraindications for breastfeeding women.

The effect of the drug on the ability to drive and operate machinery

Caution when driving and operating machinery because such as other drugs to treat hypertension, the drug can cause dizziness, dizziness, drowsiness at the beginning of treatment or when increasing the dose.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Other antihypertensive drugs may increase the hypotension effect of Losartan. Simultaneous use of Losartan with drugs such as three -round antidepressants, anti -psychotic drugs, Baclofen and amifostin may increase the risk of hypotension.

Hyassalia hyperka when used simultaneously with potassium diuretics, potassium supplements, salt replacement substitutes containing potassium.

Losartan does not have pharmacokinetic interactions with hydrochlorothiazid and oral digoxin or intravenously.

Losartan drinks with cimetidine increases the area under the curve (AUC) of Losartan by about 18%, but does not affect the pharmacokinetics of the active metabolites of Losartan.

Losartan oral with phenobarbital reduces about 20% of Losartan and of active metabolites.

rifampicin, aminoglutethimide, carbamazepin, nafcilin, nevirapin, phenytoin reduce losartan and plasma metabolites when used simultaneously.

Losartan increases the effects of drugs: amifostin, hypotension drugs, carvedilol, hypoglycemic drugs, lithiums, potassium diuretics, rituximab.

Anti-inflammatory and pain relievers (NSAID) especially COX-2 used in combination with Losartan can cause kidney failure, so kidney function should be monitored.