Lipitor 20mg Pfizer Treatment for total cholesterol (3 blisters x 10 tablets)
Dosage form Box of 3 blisters x 10 tablets
Specifications Atorvastatin
Ingredient
| Composition information | Content |
| Atorvastatin | 20mg |
Uses
Indications
Atorvastatin is appointed to support the diet in the treatment of patients with hypercholesteroline blood cholesterol predators (hyperlested blood cholesterol is heterozygous and non -family), hyperlipidemia (mixed) (LLA and LLB groups according to Fr and Frederson), increased truglycer. Blood (Group IV, according to the classification of Fredrickson) and in patients with blood betalipoprotein disorders (group III according to Fredrickson classification) without adequate response to the diet.
To reduce total cholesterol (C - total), low density lipoprotein cholesterol (LDL - C), apolipoprotein B (APO B) and triglyceride (TG) and help increase high density cholesterol lipoprotein (HDL - C).
Atorvastatin is also indicated to reduce C - Total and LDL - C in patients with hypercholesterolemia hyperlested family.
Lipitor 20mg is indicated in the following cases:
Provisions of cardiovascular complications
For patients without manifestations of cardiovascular disease (CVD) clinically, and patients with or without blood lipid disorders, but there are risk factors for coronary heart disease (CHD) such as smoking, high blood pressure, diabetes, HDL - C low, or patients with family history patients with early coronary coronary artery disease, Avortasatin is designated to:
In children (10 - 17 years old)
Atorvastatin is assigned to support diets to reduce total cholesterol, LDL - C, and APO B in boys and girls who have menstruation from 10 to 17 years old with hyperlested hyperlemom cholesterol and after treatment with appropriate diets, patients still have the following characteristics:
pharmacokinetics
Absorption
Atorvastatin absorbs quickly after drinking, reaching the peak concentration (CMAX) in plasma within 1 to 2 hours. After oral, Atorvastatin is about 95 - 99% of the film -based film bags of oral solution.
Distribution
The average distribution of Atorvastatin is approximately 381L. Atorvastatin binds plasma protein above 98%. Atorvastatin body oil should pass through the bloody barrier.
Metabolism
Atorvastatin is metabolized by Cytocrom P450 3A4 (O - and P - Hydroxylation and many different oxidant beta products). About 70% of HMG inhibitors - COA Reductase during circulation is due to active trips.
Elimination
Atorvastatin is mainly eliminated through bile after metabolism by the liver or outside the liver. The average selling time in the plasma of Atorvastatin is about 14 hours. Half of the activity of HMG - Coa Reductase inhibitors is about 20 to 30 hours due to the contribution of active metabolites.
Before taking Lipitor 20mg Pfizer Treatment for total cholesterol (3 blisters x 10 tablets)
How to use
Take oral once a day at any time, with or not accompanied by food.
Dosage
Dosage is between 10mg to 80mg once a day. The starting and maintenance dose should be concretized for each patient depending on the initial LDL - C level, the goals of treatment, and the patient's response.
Increasing primary blood cholesterol and hyperlipidemia
Most patients are controlled with atorvastatin dose 10mg x 1 time/day.
Hyper cholesterol is homozygous
Currently there is only limited data.
Atorvastatin dose in patients with hypercholesteroline hypercholesteroline hypertension is 10mg to 80mg/day, in these patients, Atorvastatin should be used as a supportive medicine for other lipid treatments (eg LDL separation) or if these methods are not available.
Cardiovascular Prevention
Dose in initial backup tests is 10mg/day. Higher doses may be taken to achieve concentration (LDL -) cholesterol according to current instructions.
Patients with renal failure
No need to adjust the dose in patients kidney failure (see the cautious part when using the drug).
Patients with liver failure
Should be carefully used lipitor in patients with liver failure. Contraindicated lipitor in patients with progressive liver disease (see the contraindications).
Elderly patients
Safety and effectiveness of drugs in patients over 70 years of age using recommended dose is similar to the common population group.
Children
Hyper cholesterol.
For patients with hypercholesteroline hypercholesterol, heterozygous family aged 20 years and older, Atorvastatin's recommended starting dose is 10mg daily, can increase daily dose up to 80mg according to the response and tolerance capacity.
What to do when overdose? In case of overdose, patients need to be treated with symptoms and use necessary support measures. Checking liver function should be performed and serum CK levels need to be controlled. Because most Atorvastatin is attached to plasma proteins, dialysis almost does not increase the excretion of avortastatin from the body.
What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using lipitor, you may experience unwanted effects (ADR).
Common, ADR> 1/100
Testing: Abnormal liver function test, increased blood creatin.
Uncommon, 1/1000 Mental: nightmares, insomnia. Skin and subcutaneous tissue: urticaria, skin rash, itching, hair loss . Rare, 1/10000 Skin and subcutaneous tissue: Neuritis, puffer dermatitis include diverse roses, Stevens - Johnson syndrome and poisoned donation. Very rare, ADR Unknown frequency
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Lipitor contraindicated in the following cases:
Hypersensitivity to any ingredients of the drug.
Having progressive liver disease or increased serum transaminase is not explained in excess of the upper limits of normal levels.
During pregnancy, breastfeeding and in women is likely to not use appropriate contraception.
Precautions for use
Effects on the liver
should conduct liver function tests before the beginning of treatment and periodically later. Patients should be tested for liver function when there are any signs or symptoms that suggest liver damage. If transaminase increased 3 times higher than the normal limit (ULN), the dose should be reduced or discontinued with Atorvastatin. Be cautious when using Atorvastatin in patients drinking a lot of alcohol or a history of liver disease.
Hemorrhagic stroke
In a post -testing analysis on mutant groups in patients without coronary artery disease (CHD) with stroke or recent brain anemia (TIC), the risk of stroke due to hemorrhage in patients starting treatment with Atorvastatin 80mg is higher than placebo. The risk increases more in patients who have had previous hemorrhagic stroke or hole infarction.
For patients who have had previous hemorrhagic strokes or blood loss, the balance between the risk and the benefits of Atorvastatin 80mg is not sure and should carefully consider the risk of hemorrhagic stroke before the beginning of treatment.
Mechanical effects - Bone
As other HMG - Coa Reductase inhibitors, Atorvastatin can sometimes affect skeletal muscles and cause muscle pain, muscle inflammation and muscle disease, which can progress to muscle and muscle, a condition that can be fatal, characterized by a significant increase in creatin kinase (CK) (> 10 times ULN), Myoglobin blood and myoglobin, can be impaired.
There have been very rare reports that have muscle necrosis through the immunity (IMNM) during or after treatment with some statins. IMNM is clinically characterized by prolonged thigh muscle weakness and increased serum creatin concentration, not all when stopping treatment with statin.
Interstitial lung disease
There has been an interstitial lung disease report when using some statins in some cases, especially when treated for prolonged treatment. The expression may include breathing, dry cough and general health reduction (fatigue, weight loss and fever). Stop taking the drug if there is a suspected patient with interstitial pneumonia.
Endocrine function
There have been reports on increasing the level of hemoglobin A1C and blood sugar when hungry when using the drug. However, the risk of hyperglycemia is lowered by a decrease in blood vessel risk to the statin group.
The ability to drive and operate machinery
unknown.
Pregnancy
contraindicated to use Atorvastatin during pregnancy.
Breastfeeding period
Effects of simultaneous medications with Atorvastatin
Atorvastatin is metabolized by Cytocrom P450 3A4 (CYP3A4) and is a substrate of transport protein such as OatP1B1 transport protein. Concomitance with CYP3A4 inhibitors or transportation proteins can increase plasma Atorvastatin levels and increase the risk of muscle disease. The risk can also increase when using atorvastatin simultaneously with other drugs can also cause muscle disease such as fibric acid derivatives and ezetimib.
CYP3A4 inhibitors
Strong CYP3A4 inhibitors (such as Ciclosporin, Telithromycin, Clarithromycin, Delavirdin, Stiripentol, Ketoconazol, Voriconazole, Itraconazol, Posaconazole and HIV Ritonavir, Lopinavir, Atazanavir, Indir, Indires, Indires, Indires Darunavir ...) can significantly increase Atorvastatin levels.
Average CYP3A4 inhibitors (such as erythromycin, diltiazem, verapamil and fluconazole) may increase plasma Atorvastatin levels.
CYP3A4 induction drugs
Used at the Atorvastatin period with CYP3A4 induction drugs (such as Efavirenz, Rifampin, St. John) can reduce plasma Atorvastatin levels.
Transport protein inhibitors (such as ciclosporin) may increase Atorvastatin levels.
gemfibrozil/Fibric acid derivatives
Only use fibrats sometimes related to mechanical events, including muscle pattern. The risk of these variables may increase when used simultaneously fibric acid derivatives with Atorvastatin. If it is necessary to use atorvastatin combination with fibric acid derivatives, the lowest dose of Atorvastatin should be effective and appropriate patient monitoring.
ezetimibe
Only use Ezetimibe sometimes related to mechanical events, including muscle pattern. This risk may increase when using Ezetimibe simultaneously with Atorvastatin.
Colestipol
Atorvastatin concentration and metabolites have active activity in plasma (radioactive Atorvastatin concentration: 0.74) when simultaneously used Colestipol with Atorvastatin. However, the effect on lipid when using Atorvastatin with Colestipol is higher than when taking only one of the two drugs.
Fusidic acid
The risk of muscle disease, including muscle pilot increases when using fusidic acid system with systemic sugar with statins.
colchicin
Be cautious when using due to a report on muscle disease.
influence Atorvastatin on other drugs used simultaneously
digoxin
When using simultaneously, the dose repeats digoxin and 10mg of atorvastatin, the concentration of Digoxin stability increases slightly.
Oral contraceptives
Simultaneous use of Atorvastatin with oral contraceptives can increase the concentration of Norethindron and Ethinyl Oestradiol.
warfarin
should determine prothrombin time before starting Atorvastatin in patients who are taking Coumarin antifiers and regularly during the first time of treatment to ensure no significant change in prothrombin time occurs. Atorvastatin is not related to bleeding or changing the time of prothrombin in patients who do not take antifinal drugs.
Children
Medicinal interaction - The drug has only been realized on adults. Drug interaction in children is unknown. Drug interactions and related warnings atorvastatin in adults should be considered for children.
Storage
Store under 30 ° C.
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