Livorax-8 tablets Micro pain and anti-osteoarthritis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Lornoxicam

Ingredient

Composition information	Content
Lornoxicam	8mg

Uses

indications

Livorax 8 drugs are indicated in the following cases:

temporarily relieve pain in the case of mild to medium acute pain. Relieve pain and anti -inflammatory in osteoarthritis. Analgesic and anti -inflammatory in rheumatoid arthritis .

Pharmacological

lornoxicam is an nonsteroidal anti -inflammatory drug (NSAID) with analgesic and anti -inflammatory activity, belonging to the Oxicam group. Like other NSAIDs, Lornoxicam's analgesic and anti -inflammatory effects are associated with Prostaglandin synthesis inhibitors through the activity inhibitors of Cyclo - Oxygenase (COX).

Pharmacokinetics

absorption

Lornoxicam absorbs quickly and completely after drinking. The peak concentration of plasma is 270 µg/l, achieved within 2.5 hours after taking a dose of 4 mg. The pharmacokinetics of Lornoxicam depends on the dose when using the dose from 2 to 6 mg, twice a day. Lornoxicam absorption speed is slowed down and the absorption level decreases (20%) in the presence of food.

Distribution

Lornoxicam is found in plasma in non -change form and metabolism of hydroxylation. Hydroxylation does not have pharmacological effects. Lornoxicam's plasma protein mounting ratio is 99% and does not depend on doses.

Metabolism

Lornoxicam is completely metabolized.

Elimination

About 1/3 of the dose is eliminated through the kidneys and the remaining 2/3 is excreted through the liver.

Lornoxicam's pharmacokinetics are the same when used for elderly patients and young patients. Lornoxicam pharmacokinetics parameters are almost unchanged in patients kidney failure . There is no need to adjust the dose for patients with liver failure, except for severe liver failure.

Before taking Livorax-8 tablets Micro pain and anti-osteoarthritis (10 blisters x 10 tablets)

How to use

Take oral use. Should take medicine before meals and drink with plenty of water. It is not recommended to use Lornoxicam tablets for children under 18 years old.

Dosage

Pain treatment: 8 - 16 mg daily, divided into 2-3 times. Total daily dose should not exceed 16 mg.

Treatment of rheumatoid arthritis and osteoarthritis: The daily starting dose is 12 mg, divided into 2-3 times. The maintenance dose should not exceed 16 mg per day. Avoid using lornoxicam for people with liver/kidney failure if possible. If used, the maximum dose is recommended for people with liver/kidney failure is 8 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget a dose?

If you forget to take a dose, drink as soon as you remember. If the time is close to the next medication, skip the forgotten dose and take the next dose at the usual time. Do not use double dose to compensate for the forgotten dose.

Side Effects

When using Livorax 8, you may experience unwanted effects (ADR).

Systemic: headache, dizziness, drowsiness, change of appetite, increased odor secretion, weight loss, edema, allergies, weakness, weight gain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Livorax 8 contraindicated in the following cases:

Patients with hypersensitivity to Lornoxicam or any ingredients of the drug.

Patients with gastrointestinal bleeding.

Patients with brain vascular hemorrhage.

Patients with stomach ulcers or patients with a history of recurrent evening ulcer.

Patients with severe liver failure, severe renal failure.

Caution when using

ulcerative and gastrointestinal bleeding

Need to monitor patient condition after certain periods. Patients with stomach ulcers and/or gastrointestinal bleeding while using Lornoxicam should stop taking the drug and need to apply appropriate treatments.

kidney failure

Patients with mild renal impairment (serum creatinine clearance rate from 150 - 300 umol/l) should be tested for precious kidney function, medium renal impairment patients (serum creatinine clearance from 300 - 700 mol/l) should be tested for kidney function every 1 to 2 months. If the renal function decreases during treatment, it is advisable to stop taking the drug.

The ability to drive and operate machinery

has not recorded the impact on the ability to drive and close to machinery.

Pregnancy

should not be used because it has not been fully studied.

The period of breastfeeding

should not be used because it has not been fully studied.

Drug interaction

Lornoxicam interact with the following drugs

Simultaneous use of Lovorax along with anticoagulants or platelets inhibitors that prolong bleeding time.

The hypoglycemic effect of sulphonylurea may increase.

Non -steroid and aspirin anti -inflammatory drugs: Increased risk of adverse reactions.

Diuretics: Reduce the effects of diuretics. NSAID antagonism of diuretics of Furosemid.

ACE inhibitors: The effect of ACE inhibitors can be reduced when used simultaneously with Lornoxicam, and combining these two drugs can cause acute renal failure.

Storage

Cool dry place, avoid light, at temperatures below 30ºC.

Other drugs

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