LODIMAX 10 OPV Pharma tablets against hypertension, angina (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Amlodipine

Ingredient

Composition information	Content
Amlodipine	10mg

Uses

indications

Lodimax drug is indicated in the following cases:

Treatment of hypertension: Amlodipine can be used as single therapy or in combination with other anti -blood pressure drugs to control blood pressure ..

Treatment of coronary artery disease: Preventing stable angina and Prinzmetal angina. Cells (slow calcium channel blockers or calcium antagonistic drugs) inhibit the calcium ion flow through the cell membrane into the heart muscle and blood vessel plain muscle.

Amlodipine is a peripheral artery relaxant thanks to the direct impact on blood vessel smooth, thus reducing peripheral blood vessels and lowering blood pressure.

The exact mechanism of relief of amlodipine's angina has not been completely determined but Amlodipine reduces myocardial ischemic with two effects below:

Amlodipine relaxes peripheral arteries and thus reduces peripheral resistance (post -burden). Because the heart rate maintains stable, this impact of the heart reduction reduces the consumption of myocardial energy and reduces oxygen demand.

Amlodipine's action mechanism may also be related to the relaxation of coronary arteries and coronary arteries, both in both anemia and normal region. This vasodilation increases the supply of oxygen for the heart in patients with coronary arteries (Prinzmetal syndrome and unstable angina).

Dynamic pharmacokinetics

absorption

Amlodipine is well absorbed through the gastrointestinal tract with peak plasma concentrations reaching 6 to 12 hours after taking a single dose. Biology of amlodipine when taking about 60 - 80%

Distribution

97.5% linked to plasma proteins.

Metabolism

amlodipine is metabolized in the liver.

Elimination

The half -life of the drug is from 35 to 50 hours. The metabolites are mostly excreted in the urine with less than 10% of the constant drug.

Before taking LODIMAX 10 OPV Pharma tablets against hypertension, angina (2 blisters x 10 tablets)

How to use

Lodimax 10 pills in the form of oral film tablets.

Dosage

adults

Dosage in case of both hypertension and angina: The normal starting dose is 5 mg once a day, which can be increased to the maximum dose of 10 mg depending on the response of each patient.

Dosage in case of treatment in hypertension patients: Amlodipine is used in combination with thiazid diuretics, alpha chen, beta blockers, or angiotensin transferred enzyme inhibitors.

Dosage in case of treatment for angina: Amlodipine can be used as single therapy or in combination with other anti -angina drugs in patients with angina without responding to nitrate and/or not responding to the appropriate dose of beta blockers.

Special subject group

Elderly patients: Use amlodipine at the same dose well well tolerated in the elderly and younger patients.

Patients with liver failure: The recommended dosage has not been determined in patients with mild to moderate liver failure. Amlodipine should be started with the lowest dose and adjust the slow doses in patients with severe liver failure.

Patients with renal failure: Normal dosage is recommended.

Children

Children and teenagers from 6 years old to 17 years old with hypertension:

Recommended dose: Starting 2.5 mg once a day, up to 5 mg once daily if the target blood pressure is not achieved after 4 weeks. Dosage exceeds 5 mg daily has not been studied in children.

Children under 6 years old: No data.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

Notice immediately to the doctor or the nearest hospital.

Remember to bring the remaining medication label or the remaining amount of medicine for the doctor to know the medicine you used.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Lodimax 10 you can experience unwanted effects (ADR).

Common, ADR> 1/100

Systemic disorders: edema.

Nervous system disorders: Sleeping, dizziness, headache.

visual disorders: visual disorders.

Cardiovascular disorders: Brushing the chest, flushing.

Respiratory disorders: Difficulty.

Digestive disorders: abdominal pain, nausea, indigestion, changing habits.

muscle and connective tissue disorders: muscle pain.

Systemic disorders: fatigue, weakness.

Uncommon, 1/1000

Mental disorders: depression, mood change (including anxiety), insomnia.

Nervous system disorders: tremor, taste, fainting, tactile reduction, paresthesia.

Tinnitus disorders: tinnitus.

Cardiovascular disorders: arrhythmia and hypotension.

Respiratory disorders: cough, rhinitis. gastrointestinal disorders: vomiting.

Skin and subcutaneous tissue: Hair loss, skin discoloration, increased secretion.

musculoskeletal and connective tissue disorders: joint pain, muscle pain, back pain.

Magic and urinary disorders: urination disorders, night urination, urination many times.

Reproductive disorders: helplessness, big breasts in men.

Systemic disorders: chest pain, pain, discomfort.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Lodimax 10 drugs contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Patients are known to be sensitive to amlodipine and other drugs in the dihydropidine group.

Hypotension.

shock, including cardiac shock.

Heart failure with unstable hemodynamics after acute myocardial infarction.

Conclusion of the release of the left ventricle (for example, aortic stenosis).

Unstable angina, except for Prinzmetal angina.

Be cautious when using

should be used with caution amlodipine for patients with liver failure, may have to reduce the dose or extend the time between the dose.

Used in children: There is no experience available to use Amlodipine children under 6 years old.

Use cautious for patients with heart failure.

The ability to drive and operate machinery

Amlodipine may have a influence on the ability to drive and operate machinery. If the patient uses amlodipine dizziness, gravity, headache, fatigue, or nausea, the body's reaction will decrease.

Pregnancy

Calcium channel blockers are likely to cause oxygen deficiency for the fetus due to the drug that causes hypotension in the mother. Therefore, this drug is not used for pregnant women unless the benefits are higher than the potential risk to the fetus.

Breastfeeding period

It is unknown whether amlodipine will excrete in breast milk or not. Therefore, you should stop breastfeeding during treatment with amlodipine.

Interactive drug

Amlodipine is used safely when combined with thiazid diuretics, beta blockers, angiotensin -shaped enzyme inhibitors, nitrate derivatives and oral hypoglycemic drugs.

Non -steroid anti -inflammatory drugs (NSAIDs), especially indomethacin, can reduce the anti -hypertension effect of amlodipine.

Anesthesia increases the anti -hypertension effect of amlodipin.

CYP3A4 inhibitors: simultaneously use Amlodipine with strong or medium CYP3A4 inhibitors (protease inhibitors, antifungal drugs azol, macrolid such as erythomycin or clarithromycin, verapamil or diltiazem) can increase the risk of lowering blood pressure.

Do not use amlodipine with grapefruit or grapefruit juice because it can increase the bioavailability amlodipine in some patients, leading to increased hypotension.

dantrolen (infusion): Should avoid simultaneous use of calcium channel blockers like amlodipine.

Storage

At temperatures below 30 ° C, in a dry place, avoiding light.

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