Lopenca DHG Pharma medicine relieves pain, anti -inflammatory injury, rheumatism, neuritis (5 blisters x 20 tablets)

Dosage form Box of 5 blisters x 20 tablets
Specifications Paracetamol, ibuprofen

Ingredient

Thành phần cho 1 viên

Composition information	Content
Paracetamol	325mg
Ibuprofen	200mg

Uses

Indications

Lopenca has the effect of relieving pain, anti -inflammatory effects in cases of muscle and joint pain due to trauma, rheumatism, neuritis such as back pain, crooked neck, sprain, excessive muscle tension, fracture, dislocated after surgery ...

Treatment of fever, headache, toothache, dysmenorrhea, exercise ...

Pharmacy

Lopenca is an analgesic, anti -inflammatory drug combined from 2 active ingredients:

Paracetamol is an effective analgesic - antipyretic. The drug acts on the central cashew center in the hypothalamus, causing cooling, increasing heat caused by vasodilation and increasing peripheral blood flow reduces body temperature in people with fever, but rarely reduces normal body temperature. Pain relief by lifting the threshold of pain.

ibuprofen is an nonsteroidal anti -inflammatory drug, has analgesic, antipyretic and anti -inflammatory effect. Ibuprofen inhibits prostaglandin synthetase and thus prevents prostaglandin, inflammation, pain and fever.

With combined pain relief formula, Lopenca is used in muscle, bone, joint pain and injury pain.

pharmacokinetic

Paracetamol absorbs quickly and almost completely through the gastrointestinal tract. The sale time is 1.25 - 3 hours. Metabolic drugs in the liver and excreted through the kidneys.

ibuprofen absorbs well, the maximum concentration of the drug in plasma is achieved after 1-2 hours. Half life of the drug is about 2 hours. The drug is excreted mainly in urine.

Before taking Lopenca DHG Pharma medicine relieves pain, anti -inflammatory injury, rheumatism, neuritis (5 blisters x 20 tablets)

How to use

Take medicine after meals.

Dosage

Adults: Take 1-2 capsules x 2-3 times/day. Or as directed by the physician.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Paracetamol overdose due to a single -dose or a repeated repeated dose of paracetamol (7.5 - 10g a day, for 1-2 days) or for long -term medication. Liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be fatal.

Manifestations of paracetamol overdose: Nausea, vomiting, abdominal pain, symptoms of blue -purple skin, mucosa and nails.

When paracetamol poisoning is severe, it is necessary to treat actively. Need to wash the stomach in any case, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds. N - Acetylcystein works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol. Treatment with N - Acetylcystein is more effective when giving the drug for less than 10 hours after taking paracetamol. When drinking, dilute N - Acetylcystein solution with water or drinks without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing. Give N - Acetylcystein with the first dose of 140mg/kg body weight, then give 17 more doses, each dose of 70mg/kg body weight every 4 hours apart.

In addition, methionine, activated carbon and/or salted carbon.

Overdose and management of ibuprofen

usually treat symptoms and support. If you have overdose, it is necessary to apply the following measures to increase elimination and inactivity: gastric lavage, vomiting and diuretic, drinking activated carbon or salt bleach. If severe: hemorrhage or blood transfusion. Because the drug causes acidosis and elimination in the urine, theoretically will benefit when transmitting alkaline and diuretic.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Lopenca, you may experience unwanted effects (ADR). Some side effects recorded in research on users of this drug are: digestive disorders such as nausea, vomiting, indigestion, stomach pain, epigastric pain, gastrointestinal bleeding, headache, dizziness.

Notify the doctor with unwanted effects when using the drug.

Warnings

Contraindicated

Lopenca drugs are contraindicated in the following cases:

sensitive to one of the ingredients of the drug.

Stomach ulcer - duodenum progresses.

Patients with asthma or bronchospasm, bleeding disorders, cardiovascular disease, glue.

hypersensitively to aspirin or other nonsteroidal anti -inflammatory drugs.

Patients with congestive heart failure, decreased volume of circulatory amounts due to diuretic or kidney failure.

Pregnant women in the last 3 months.

Precautions when taking the drug

must be used cautiously in people with liver failure, kidney failure and alcoholism.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking.

Be careful when using ibuprofen for the elderly.

ibuprofen inhibits platelet capacitors so it can cause prolonged bleeding time.

Doctors need to warn the patient about signs of serious skin reactions such as Steven - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The ability to drive and operate machinery

Be cautious when driving and operating machinery because the drug can cause headaches, dizziness.

Pregnancy and lactation

Pregnancy

Do not use drugs during pregnancy, especially in the last 3 months of pregnancy.

Breastfeeding period

The drug in breast milk is very small, negligible. Less likely to occur risks for children at normal doses with mothers.

Medicinal interaction

Long -doses of high -dose Paracetamol increases the anticoagulant effect of COUMARIN and conducting indandion.

Pay attention to the likelihood of serious antipyretics in patients with phenothiazine and cooling therapy.

Anti -convulsions (Phenytoin, Barbiturat, Carbamazepin) cause enzyme induction in the liver microsom, which can increase the toxicity of the liver toxicity of paracetamol due to increased drug metabolism into toxic substances to the liver.

Simultaneous use of isoniazid with paracetamol can lead to an increased risk of toxicity to the liver.

ibuprofen increases the side effects of quinolon antibiotics on the central nervous system, increasing the toxicity of methotrexate and digoxin.

Used with other nonsteroidal anti -inflammatory drugs increases the risk of bleeding and peptic ulcer.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer.

You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist.

Keep pills out of reach of children and pets.

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