Loperamide Stella 2mg hard capsules reduce acute diarrhea (5 blisters x 10 tablets)

However, some information that the drug can act like diphenoxylate and morphine, by increasing the contraction of the sphincter system in the intestine, therefore increasing segmentation and slowing the peristalsis push to the intestine.

Loperamid prolongs the circulation time through the intestine and thus reduces the integral, increases viscosity and dry density of the feces, reduces the loss of fluid and electrolytes. As an anti-diarrhea drug, Loperamid is recognized as a more specific drug, longer impact and effective 2-3 times stronger based on weight than Diphenoxylate. There is no tolerance to the anti -diarrhea effect of loopamid.

Pharmacokinetics

absorption

approximately 40% of the oral dose of loopamid is absorbed through the gastrointestinal tract.

Distribution

The concentration of lactation through milk is very low. Linking with protein is about 97%.

Metabolism

The drug is metabolized in the liver into an inactive form (over 50%).

Elimination

Excretion of molasses in the form of conjugate in the form of unnoticed, excretion through urine is negligible. The half -life of loopamid in humans is about 7 - 14 hours.

Loperamid is not recommended for children regularly in acute diarrhea.

Do not recommend for children under 6 years old.

chronic diarrhea

Adults:

The starting dose is 4 mg, followed by 2 mg after each loose bowel movement until the control of diarrhea, then reducing the dose depending on the needs of each individual, when the daily dose is determined, this dose may be used once or divided many times.

The average daily maintenance dose in clinical studies is 4 - 8 mg.

rarely exceeds the dose of 16 mg. Almost no control of symptoms at higher dose if clinical does not improve after treatment at a dose of 16 mg/day for at least 10 days.

Can continue using loopamid if diarrhea is not controlled adequately with a specific diet or treatment.

Children:

The dose has not been determined.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

In cases of overdose. The central nodules may occur and inhibit the central nervous system, affecting the central nervous system in children more sensitive in adults. Clinical studies have shown that the use of activated carbon chaos day after taking Loperamid hydrochloride may reduce 9 times the amount of drugs absorbed into the circulatory system.

If vomiting occurs spontaneously while taking the medication, drinking the mixture contains about 100 grams of activated carbon as soon as it can maintain the fluid. If you do not vomit, gastric lavage should be carried out after drinking 100 grams of activated carbon mixture through the gastric catheter.

In case of overdose, patients should be monitored central nerve inhibition signs for at least 24 hours. If observations have central neurological inhibition, naloxon can be used. If responding well with naloxon, careful monitoring of signs for at least 24 hours after the last dose of Naloxon.

Due to the prolonged impact of loopamid and the short impact time of naloxon (1-3 hours), the patient closely monitor and repeated treatment with Naloxon as prescribed.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Be cautious when using

loss of fluid and electrolytes often occur in patients with diarrhea. In these cases, water and electrolytes are very important. Loperamid use does not hinder the need for water and electrolytes.

In some patients with acute colon ulcer and fake colitis related to the use of broad -spectrum antibiotics, intestinal peristalsis or delayed time through the intestinal circulation has been reported as an enlarged colon.

Should stop using loopamid immediately if abdominal distention occurs, constipation or intestinal obstruction. Loperamid should be particularly cautious in children due to the change in more in this age group.

Dehydration, especially in young children, can further affect the change in response to loopamid.

In acute diarrhea, if clinical does not improve in 48 hours, should stop using loopamid.

Patients with liver function failure should be closely monitored by the central nerve signs due to the first metabolism through the liver.

Patients should consult a doctor if diarrhea does not improve after 2 days of medication or see blood in the stool or fever.

The ability to drive and operate machinery

Loperamid does not affect alertness, but if you are tired, dizzy or drowsy, you should not drive or operate machinery.

Pregnancy

There are not enough studies on pregnant women. Do not use for pregnant women.

Lactating period

Loperamid secretes milk very little, can be used for mothers who are breastfeeding but at low doses.

Interactive drug

Increased toxicity: Central nervous system inhibitors, phenothiazine, 3 -round antidepressants can increase the desired effect of loopamid.