Lorastad D 5mg Stella tablets reduce allergic rhinitis, urticaria (3 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 3 blisters x 10 tablets
Ingredient Desloratadine

Ingredient

Composition information	Content
Desloratadine	5mg

Uses

indications

Lorastad d medicine to treat symptoms of:

Allergic rhinitis . After oral dosage, desloratadine prevented the peripheral H1 receptor selective because the desloratadine does not penetrate into the central nervous system. The anti-allergic effect of desloratadine includes the ability to prevent the release of inflammatory cytokin such as IL-4, IL-6, IL-8, and IL-13 in mast cells or alkaline leukocytes in the human body, and prevent the molecular connection of P-Selectin molecules on endothelial cells.

pharmacokinetics

absorption:

After taking the dose of Desloratadine 5 mg 1 time/day for 10 days on healthy volunteers, the average time to reach the maximum concentration in plasma (TMAX) is about 3 hours.

Peak of plasma peaks in a stable state (CMAX) and the area below the concentration - time curve (AUC) are 4 ng/ml and 56.9 ng. Food or grapefruit juice does not affect the bioavailability (CMAX and AUC) of the desloratadine.

Distribution:

Desloratadine and 3 -Hydroxydesloratadine associated with plasma proteins are about 82 - 87% and 85 - 89% respectively. The ability to bind to the plasma protein of desloratadine and 3-hydroxydesloratadine does not change in the person with renal function.

Metabolism:

Desloratadine (a main metabolic substance of Loratadine) is strongly converted into 3-hydroxydesloratadine, an active metabolite, this substance is then glucuronicization. The enzyme has not been determined to form 3-hydroxydesloratadine.

Information from clinical trials shows a small part of the population that is limited in forming 3-hydroxydesloratadine and the metabolism of desloratadine in these people is low.

Era:

Desloratadine average sale time is about 27 hours. The value of CMAX and AUC increases in a single dose ratio in the range of 5 - 20 mg. The level of accumulation after 14 days of drug use remains stable in the sale time and the frequency of dosage.

A study of mass balance in humans shows that the recovery of the 14C-Desloratadine dose is about 87%, equivalent to the distribution of urine and feces as a metabolic product. 3-Hydroxydesloratadine analysis for TMAX value and similar selling time compared to desloratadine.

Before taking Lorastad D 5mg Stella tablets reduce allergic rhinitis, urticaria (3 blisters x 10 tablets)

How to use

Lorastad D is assigned orally. The drug can be taken with or not with food.

Dosage

Adults and children aged 12 years and older: The recommended dose of Lorastad D is 1 capsule 1 time/day.

Non -continuous allergic rhinitis (symptoms that appear

prolonged allergic rhinitis (symptoms that appear> 4 days/week and last> 4 weeks), the treatment may continue for patients in the exposure stage of allergies.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? Recommendation of the use of symptomatic treatment and supportive treatment. In a high -dose clinical trial, orally orally 45 mg Desloratadine (9 times the recommended dose), no overdose reaction.

Desloratadine is not excluded by a hemorrhage, it is not known whether the drug is excluded by the peritoneal absorbent.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

Common disorders: fatigue.

No report.

Mental: illusion. Liver, hyperpigmentation, hepatitis.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Lorastad d drug contraindicated in the following case:

Hypersensitivity to desloratadine, Loratadine or any ingredients of the drug.

Be cautious when using

The safety and effectiveness of desloratadine in children under 12 years of age has not been established.

In case of severe renal failure, caution should be cautious when using desloratadine.

The ability to drive and operate machinery

In clinical trials assessing the ability to drive in patients using desloratadine, this ability is not impaired. However, patients should note that there are very rare cases that users have a feeling of sleeping, which can affect the ability to drive or use machines.

Pregnancy

Desloratadine is studied without causing teratogenic animals. Safety when using drugs during pregnancy has not been reported. Therefore, it is not recommended to use desloratadine during pregnancy.

breastfeeding period

desloratadine into breast milk, so it is not recommended to use desloratadine in breastfeeding women.

Drug interaction

There is no clinical report related to drug interactions in the clinical trials of desloratadine when used simultaneously with erythromycin or ketoconazole.

In a pharmacological clinical trial, when using simultaneously desloratadine with alcohol, unable to weaken the effects of alcohol.

Storage

Store in closed packaging, dry place. The temperature does not exceed 30 ° C.

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