Loreze 10mg soft capsules treatment for allergic rhinitis, urticaria (5 blisters x 10 tablets)

Dosage form Soft capsules
Specifications Box of 5 blisters x 10 tablets
Ingredient Loratadine

Ingredient

Composition information	Content
Loratadine	10mg

Uses

indications

Loore pills are indicated in the following cases:

Treatment of allergic rhinitis symptoms: runny nose, sneezing, itchy nose or throat.

Treatment of spontaneous symptoms.

Pharmacology

Loratadin is a long -lasting histamine resistance. The drug has a selective antagonistic activity on the H1 receptor on the periphery and is considered a second -generation antihistamine.

Dynamic pharmacokinetics

Loratadin quickly absorbed after drinking. The average plasma peak concentration of loratadin and metabolites (desloratadin) is achieved by 1.5 and 3.7 hours respectively.

After taking Loratadin, the antihistamine resistance of the drug appears within 1-4 hours, starting the antihistamine impact appears when the correlation between Loratadin's absorption concentration and the formation of desloratadin.

97% Loratadin binds to plasma proteins. Loratadin's disposal time is 17 hours and of desloratadin is 19 hours. Half of the drug of the drug transforms a lot between individuals, is not affected by blood urea, increasing in the elderly and people with cirrhosis.

The clearance of the drug is 57-142 ml/min/kg and is not affected by blood urea but reduces people with cirrhosis. The distribution of the drug is 80 - 120 liters/kg.

Loratadin metabolizes a lot when passing the liver for the first time by the microsom cytochrom P450 enzyme system; Loratadin mainly converted into carbohoxyloratadin, which is a pharmaceutical effect.

About 80% of the total dose of loratadin secreted the urine and stool equally, in the form of metabolites, within 10 days.

Before taking Loreze 10mg soft capsules treatment for allergic rhinitis, urticaria (5 blisters x 10 tablets)

How to use

loreze orally.

Dosage

Adults and children over 12 years: 1 tablet once a day or as directed by the doctor.

Children 2 - 12 years old: The dose is calculated by weight.

weight> 30 kg: 1 tablet (10 mg) oral once a day.

Weight ≤ 30 kg: Loreze Clearcap is not suitable for children to weigh ≤ 30 kg.

For patients with liver failure, Loratadine clearance decreases, thus taking a dose of 1 tablet (10 mg) every two days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? In adults, the overdose (e.g. 40-180 mg) vows to be drowsy, tachycardia, and headache.

In case of overdose, symptomatic treatment should be immediately treated. It is possible to stimulate vomiting (eg with ipeca syrup) if the patient is awake. Using activated carbon after vomiting can be helpful to prevent Loratadine absorption. If vomiting does not work or contraindicated, the stomach can be carried out with 0.9% sodium chloride solution or with water.

Monitor patients closely after emergency treatment to inhales gastric fluid, especially for children.

Loratadin is not eliminated by a hemorrhage.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Loreze, you may experience unwanted effects (ADR).

Unwanted unwanted effects include fatigue, headache, drowsiness, dry mouth, digestive disorders such as nausea, gastritis, and allergic symptoms such as rash.

Rarely see cases of hair loss, anaphylaxis, abnormal liver function, tachycardia, chest drum.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Loreze drugs contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Be cautious when used

Patients with liver failure or renal failure (clearance

Not yet confirmed the safety and effectiveness of Loratadin when used for children under 02 years old.

Stop taking medication or notify your doctor when an allergic reaction appears.

The ability to drive and operate machinery

Loratadin does not or does not significantly affect the ability to drive and operate machinery. However, it is necessary to notify the patient about the condition of drowsiness occurring on a few patients.

Pregnancy

has not confirmed the safety when using the drug during pregnancy; Therefore, only when the benefits of the drug are more beneficial than the possible risks to the fetus.

breastfeeding period

because loratadin is excreted through breast milk and increases the risk of antihistamines on newborns and premature babies, should either stop breastfeeding or have to stop the drug during breastfeeding.

Drug interaction

controlled clinical trials shows an increase in plasma Loratadin concentrations after use simultaneously with ketoconazole, erythromycin, clarithromycin or cimetidine, but there is no significant change (including changes on the center of the center).

The effect of drugs on test results:

Should stop using Loratadin about 48 hours before conducting skin testing processes because antihistamine drugs may lose or reduce signs of skin -positive reactions.

There may be interactions between Loratadin and CYP3A4 and CYP2D6 inhibitors, resulting in increased Loratadin levels, thus increasing unwanted effects.

Storage

In a cool, dry place, avoid light, temperatures below 30 ° C.

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