Lornomeyer 4 Meyer pain relief, anti -osteoarthritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Lornoxicam

Ingredient

Composition information	Content
Lornoxicam	4mg

Uses

indications

Lornomeyer 4 drugs are used to treat mild and medium pain, accompanied by inflammatory symptoms, especially in osteoarthritis, rheumatoid arthritis.

Pharmacology

Pharmacological group: nonsteroidal anti -inflammatory drugs

ATC code: M1AC05

Lornoxicam is an non -steroid anti -inflammatory drug (NSAIDs) of the Oxicam group. Like some other nonsteroidal anti-inflammatory drugs, Lornoxicam is a strong inhibitor of cyclooxygenase enzyme (COX-1 and COX-2), the enzyme is responsible for the Prostaglandin synthesis (intermediate substance that plays an important role in the pathogenesis of inflammatory, fever, pain) and thromboxan from Arachidonic acid. Unlike other NSAIDs, Lornoxicam's cyclooxygenase inhibition does not increase Leukotriene, the results minimize the risk of unwanted effects.

pharmacokinetics

Lornoxicam is absorbed quickly and almost completely through the digestive tract (90 - 100%).

Lornoxicam binds to plasma proteins about 99% (mainly with albumin). Lornoxicam is completely metabolized by CYP 2C9, the main metabolite is 5'-hydroxy-lornoxicam and an negligible amount of Lornoxicam has not been metabolized in urine. About 2/3 of the drug is eliminated through the liver and 1/3 through the kidneys in the form of activity. Selling time from 3 to 5 hours.

Before taking Lornomeyer 4 Meyer pain relief, anti -osteoarthritis (3 blisters x 10 tablets)

How to use

Lornomeyer 4 drug used to drink with plenty of water.

Dosage

Considering the potential benefits/ risks of Lornoxicam and other treatment options before using the drug. The lowest dose should be used in the shortest time in accordance with the treatment goals of each patient. After responding to the initial treatment, adjust the dose to suit the needs of each patient.

For mild and moderate pain: The recommended dose is from 8 - 16mg/day, divided into 2 to 3 times. The total daily dose must not exceed 16mg.

For osteoarthritis, rheumatoid arthritis: initial recommended dose is 12mg/day. The maintenance dose must not exceed 16mg/day.

Elderly: No dose adjustments unless there is impaired liver or kidney function, in this case the daily dose should be considered.

Patients with mild and mild liver and kidney failure should take a maximum daily dose of no more than 12mg divided into 2 to 3 times.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Handling: In case of overdose, immediately stop taking the drug, symptomatic treatment and support. No specific antidote.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

About 16% of patients (in the case of 20-25% long -term treatment) may have unwanted effects related to 5% gastrointestinal tract related to common disorders and or central nervous system disorders and 2% skin -related.

Like other NSAIDs including Oxicam, the following undesirable reactions may occur:

Common disorders: headache, dizziness, sleep, loss of appetite, sweating, weight loss, edema, weakness, slight weight gain. Rectal bleeding.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Lornomeyer 4 drugs are contraindicated in the following cases:

Hypersensitivity to Lornoxicam or any ingredients of the drug. different. grant.

Pregnant or lactating women.

Be cautious when using

Heart thrombosis:

Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, use systemic sugar, may increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients should be warned of symptoms of serious cardiovascular events and need to visit the doctor as soon as they appear.

To minimize the risk of adverse events, Lornoxicam is required at the lowest daily doses to be effective in the shortest possible time.

Only use Lornoxicam after evaluating the benefits and risks for the following cases:

History of stomach - intestinal ulcer and hemorrhage. Patients with stomach ulcers or gastrointestinal bleeding when taking Lornoxicam should stop using and performing the treatment effect

Patients with mild kidney failure (serum creatinine 20 - 50 ml/min) should be tested for precious renal function; Patients with medium renal failure (serum creatinine 20 - 10 ml/minute) should be tested for kidney function periodically every 1 to 2 months. During the treatment process, if the renal function decreases, it should be discontinued using Lornoxicam. (Haemoglobin), renal function (creatinin) and liver enzymes are recommended. It is known that kidney damage can be damaged.

The effect of the drug on driving and operating machinery

Patients with a history of dizziness or other central neurological disorders when using NSAIDs should avoid controlling vehicles or operating the machine when using Lornoxicam.

Use drugs for women during pregnancy and lactation

pregnancy: Lornoxicam's safety with pregnant women has not been determined. Therefore, this drug should not be used for pregnant women.

Breastfeeding period: It is not known whether the drug is secreted into breast milk, so it should not be used for women who are breastfeeding.

Drug interaction

Other NSAIDs: Increasing the risk of gastrointestinal bleeding due to the impact of synergies.

Oral anticoagulant, ticlopidin, heparin, thrombolytic drugs: increase the risk of bleeding, so avoid coordination. During the treatment process, it is necessary to closely monitor the anticoagulant effect.

Lithi: Increases the level of lithium in the blood, so it is necessary to monitor the level of lithium in the blood during use in combination with two drugs together.

Methotrexate: Increasing the toxicity of methotrexate on the hematopoietic system, so it is necessary to count blood cells periodically.

IUD: reduces the effectiveness of contraceptives of the IUD in the uterus.

Diuretic gums: may increase the risk of acute renal failure in dehydrated patients. In case of combination, it is necessary to pay enough water for patients and must monitor the function carefully.

Anti-blood pressure drugs such as alpha-adrenergic inhibitors, angiotensin-shifting enzyme inhibitors, vasodilators: reducing vasodilation, lowering blood pressure of combined drugs.

cholestyramin: Reducing the absorption and increase of Lornoxicam elimination.

Cyclosporin: Increases the toxicity on the kidneys, so when combined, you need to monitor the function carefully.

warfarin: may increase bleeding, so it is necessary to monitor bleeding time when used.

Furosemid and Thiazid: The drug reduces the diuretic effect of Furosemid and the thiazid group.

Storage

Store drugs in dry, temperatures not exceeding 30 ° C, avoiding light.

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