Losapin 100mg SPM treatment for hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Losartan

Ingredient

Composition information	Content
Losartan	100mg

Uses

indications

Losapin 100 drugs are indicated in the following cases:

Hypertension treatment: Losartan potassium can be used monomers or in combination with other hypertension medications.

Pharmacological

Angiotensin II causes vascular contractions, stimulates aldosterone secretion and is an important component in the pathophysiology of hypertension. Both Losartan and carboxylic acid metabolites are also active, preventing the effect of vascular shrink and aldosterone secretion of Angiotensin II by inhibiting ACE, which is Angiotensin I into angiotensin II and catalyzed Bradykinin degeneration.

Losartan is the first substance of the new anti -hypertension drug group, a receptor antagonist (Type AT1) Angiotensin II.

angiotensin II, made up of angiotensin I in the reaction due to enzyme switching angiotensin (ACE) catalyzed, is a strong vasoconstrator. It is the main hormone that activates the Renin -Angiotensin system, and is an important component in the pathological physiology of hypertension. Angiotensin II also stimulates the adrenal glands of Aldosterone.

Losartan and the main metabolites have the active clogging of vascular and aldosterone secretion of Angiotensin II by preventing select Angiotensin II, not attached to the AT1 receptor in many tissues (for example, blood vessel smooth muscles, adrenal glands). In many tissues, there is also a AT2 receptor but it is not clear whether this receptor is related to the cardiovascular air conditioner or not.

Both Losartan and the main active metabolites do not show the local dominant effect in the AT1 receptor and have a much larger AT1 receptor (about 1000 times) than the AT2 receptor. Losartan is a competitive, reversible inhibitor of AT1 receptor.

The metabolic substance has the activity of drugs 10 to 40 times stronger than Losartan, calculated by weight and is a non -competitive, reversible inhibitor of the AT1 receptor. Angiotensin II antagonists also have hemodynamic effects such as ACE inhibitors, but there is no unwanted effect of the common ACE inhibitors are dry cough.

pharmacokinetics

absorption:

Losartan Kali is well absorbed from the digestive tract after drinking. Losartan potassium is about 33%. The average peak concentration in Losartan's blood and metabolites is active in respectively for about 1 hour and 3–4 hours, respectively. The maximum concentration in Losartan's blood and metabolites has equal activity.

Distribution:

Both Losartan and active metabolites are associated with plasma proteins, mainly albumin. The research in the mouse shows that Losartan passes through a very poor brain barrier.

Metabolism:

About 14% of Losartan's oral dose is converted into active metabolites.

Before taking Losapin 100mg SPM treatment for hypertension (3 blisters x 10 tablets)

How to use

oral medication.

Dosage

Normal starting dose: 50 mg x 1 time/day.

The starting dose of 25 mg x 1 time/day is used in patients with a decrease in internal volume (patients treated with diuretics) and patients with a history of liver failure.

can increase the dose to 100 mg/day, drink one or two times.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptomatic treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Losapin 100, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Cardiovascular: lower blood pressure.

Central nervous system: insomnia, dizziness.

Endocrine - Chemistry: hyperkalemia.

digestive: diarrhea, indigestion.

Hematology: Light hemoglobin and hematocrit.

Muscle muscle: back pain, leg pain, muscle pain.

kidney: lower blood uric acid (when high doses).

Respiratory: cough (less when using ACE inhibitors), nasal congestion, sinusitis.

Uncommon, 1/1000

Cardiovascular: Hypotenary pressure vertical, chest pain, Block A - V degree II, Brushing chest drum, Sinus slow rhythm, tachycardia, facial edema, blush.

Central nerve: anxiety, loss of air conditioning, confusion, depression, migraine, headache, sleep disorders, fever, dizziness. Skin: Dermatitis, dry skin, erythema, light sensitivity, itching, urticaria, bruises, foreign rash.

Section - Chemistry: Gout.

digestive: anorexia, constipation, flatulence, vomiting, loss of taste, gastritis.

Genitals - Urology: Help, sexual reduction, urination, night urine. liver: slight increase in liver function tests and slight increase bilirubin.

muscle and skeletal: Perseverance, vibration, bone pain, muscle weakness, joint edema, muscle fibrosis. eyes: blurred vision, conjunctivitis, vision loss, burning, eye aches.

ears: tinnitus. kidney: Urinary tract infections, slight increase in creatinine or urea.

Respiratory: Difficulty breathing, bronchitis, nosebleeds, rhinitis, airbornment, discomfort in the throat.

Sweating.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Losapin 100 contraindicated drug in the following cases:

allergies to any ingredient of the drug.

Pregnant women, nursing women, children and adolescents under 18 years of age because there is no data on safety and effectiveness.

Be cautious when using

Do not overdose.

Do not share the same Losartan potassium with diuretics holding potassium. Need to monitor blood potassium concentration in the elderly and kidney failure.

Efficiency and safety level of Losartan Kali has not been determined in children under 18 years old.

Some elderly people may be more sensitive to Losartan, so start with lower doses. The starting dose should be lower for people over 75 years old.

People with a shortage of circulating volume may occur blood pressure at the beginning of treatment. These patients should take a lower starting dose.

Changes on kidney function have been recorded in sensitive patients treated with Losartan. People with renal function depend on the renin -analiotensin system or Losartan has encountered a condition of urinary tract and/or nitrogen progressive.

Should take lower doses for patients with liver failure and patients with average to severe renal failure.

For patients with kidney stenosis on the one side or on both sides, using metabolic inhibitors or Losartan can increase blood urea nitrogen urea or serum creatinine.

The ability to drive and operate machinery

Motorcyclists should avoid the above activities if there is a side effect like dizzy.

Pregnancy

Using drugs directly on the Renin - Antiotensin system in the middle and the last three months of pregnancy can cause less amniotic fluid, lower blood pressure, anuria, urinary, face deformation and death in newborns.

Although the use of drugs in the first three months of pregnancy has not seen the risk of the fetus, when detected pregnancy, it is necessary to stop Losartan as soon as possible. When you need to use the doctor's consultation.

The period of breastfeeding

It is unknown whether Losartan is secreted in breast milk, but there is a significant amount of Losartan and the active metabolitus of the drug that exists in mice. Due to harmful potential for breastfeeding children, they must decide to stop breastfeeding or stop drugs based on the importance of the drug for the mother.

Medicinal interaction

simultaneously with cimetidine may increase the level of Losartan potassium in serum.

Concentrated with phenobarbital can reduce the level of Losartan Kali and serum activity.

can gently increase blood urea nitrogen urea, serum creatinine, serum bilirubin or liver enzymes.

Storage

In a dry place, avoid light, temperature below 30ºC.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.