Losarlife-H 50mg/12.5mg Eurolife tablets for high blood pressure (3 blisters x 10 tablets)

Losartan is the first substance of the new anti -hypertension drug group, which is a receptor antagonist (type at,) angiotensin II.

angiotensin II, made up of angiotensin I in the reaction of the enzyme transferred Angiotensin (ACE) catalyzed, is a strong vascular contract; It is the main hormone that activates the Renin - Angiotensin system, and is an important component in the pathophysiology of hypertension.

Angiotensin II also stimulates the adrenal glands of aldosteron.

Losartan and main metabolites have a clogging and aldosteron secretion of Angiotensin II by preventing Angiotensin II selective, not attached to AT receptors, found in many tissues (for example, blood vessel muscles, adrenal glands).

In many tissues, there is also a AT receptor, but it is unclear whether this receptor has nothing to do with the cardiovascular air conditioner. Both Losartan and main active metabolites do not show the effect of the AT receptor owner, and have the affinity for the AT receptor, much larger (about 1,000 times) than the AT2 receptor.

Losartan is a competitive, reversible inhibitor of AT receptors. The metabolic substance is more than 10 to 40 times stronger than Losartan, calculated by weight and is a non -competitive, reversible inhibitor of the AT1 receptor.

Angiotensin II antagonists also have hemodynamic effects such as ACE inhibitors, but there is no unwanted effect of the common ACE inhibitors are dry cough.

hydrochlorothiazid

The mechanism of hypotension of the Thiazide group is not known. Thiazid usually does not have the effect of normal blood pressure, hydrochlorothiazid is a diuretics and hypotension. Has the effect of
electrolyte reabsorption in the distance. Hydrochlorothiazid increases the excretion of sodium and chloride at approximately equal. Sodium-may be accompanied by potassium and bicarbonate loss.

After oral use, diuretics began to work after 2 hours, and reached peak after about 4 hours and lasted for about 6-12 hours.

Dynamic pharmacokinetics

absorption

losartan:

losartan:

losartan:

losartan:

Potassium Losartan and Hydrochlorothiazid are not recommended for use for patients with severe renal impairment (30 ml/minute creatinine clearance) or patients with liver failure.

No need to adjust the starting dose of potassium Losartan and Hydrochlorothiazid 50-12.5 for elderly patients.

Reducing the risk of cardiovascular disease and cardiovascular death in patients with high blood pressure with left ventricular hypertrophy:

Be cautious when using

Hypersensitivity: Evana.

Do not use potassium losartan and hydrochlorothiazide in people with liver failure or severe renal failure of creatinine clearance

losartan:

Effects on metabolism and endocrine:

Race:

According to Losartan intervention research to reduce consequences in people with hypertension (Losartan intervention for endpoint reduction in hypertension (Life), no conclusions about the benefits on the incidence of cardiovascular disease and the death rate of cardiovascular disease of the group using Losartan compared to the atenolol group on black skin hypertension and eligibility for both left ventricular and eligible for both effective, even though the effect is achieved. Black skin disease group is treated.

In general, in the Life Research Complex (N = 9193), in the group of losartan, synthesizing the consequences of the first, including cardiovascular mortality, stroke and myocardial infarction, reduced by 13.0% (P = 0.021) compared to the atenolol group.

In this study, compared to Atenolon, Losartan reduced the risk of cardiovascular disease and cardiovascular death on patients without black hypertension with left ventricular hypertrophy (n = 8660) is measured by the first incident, including cardiovascular, stroke, and myocardial infarction (P

However, in this study, black skin patients treated with Atenolol are less likely to be more likely to be developed than those who are treated with black skin with Losartan (P = 0.03). In the division of black skin patients (n = 533; accounting for 6%of the Life study), 29 first-class events among 263 patients were treated with Atenolol (11%, 25.9 for 1000 patients-in-year) and 46 primary events among 270 patients (17%, 41.8 for 1000 patients-in-year) treated with Losartan.

The impact of drugs when driving operating machinery

so far, no information proves that Kali Losartan and Hydrochlorothiazide have influenced the ability to drive or operate the user's machines.

used for pregnant and lactating women

during pregnancy:

When used in the second quarter and the third quarter of pregnancy, the directly acting medications to contact renin-angiotensin can cause damage to the fetus, even death for the developing fetus. When detecting pregnancy, it is necessary to stop potassium losartan and hydrochlorothiazid as soon as possible.

In humans, the excretion of the kidneys of the fetus depends on the development of the renin-ankiotensin system starting from the second quarter of pregnancy, so the risk of pregnancy will increase, if the mother uses potassium Losartan and hydrochlorothiazide in the second and third quarter of pregnancy.

Thiazid passes through the fetus fence and appears in the umbilical cord blood. It is not recommended to use gums for healthy pregnant people and this can bring both mother and pregnancy to unnecessary risks, such as jaundice of fetus and neonatal, thrombocytopenia and maybe other harmful reactions that have been encountered in adults.

The diuretics are not preventing the development of pregnancy toxicity and there is no reliable evidence that the diuretic is useful to treat pregnancy toxicity.

Breastfeeding period:

Because of the harmful effect of breastfeeding, it is necessary to decide or stop breastfeeding or stopping the drug, depending on the importance of taking the drug with the mę.

Drug interaction

Losartan:

In clinical pharmacokinetics tests, any clinical interactions have not been determined with hydrochlorothiazid, digoxin, warfarin, cimetidin, phenobarbital (please read the hydrochlorothiazid section: Alcohol, Barbiturates or addictive drugs at the lower part) Ketoconazole and erythromycin.

There have been reports on reducing the level of metabolites that are active in rifampin and fluconazole. The clinical value of these interactions has not been fully evaluated.

As with other drugs in the Angiotensin II closing group or have the same effect, when used with potassium-keeping pills (such as spironolacton, triamteren, amilorid), potassium supplements, salt-containing substances containing potassium, can lead to increased potassium-bar.

As well as other drugs that affect the excretion of sodium, can also reduce the lithium secretion. Therefore, if lithium salt is used with Angiotensin II receptor inhibitors, the amount of lithium must be monitored in serum.

Steroid anti-inflammatory drugs (NSAIDs) including cyclooxygenase-2 inhibitors (COX-2 inhibitors) can reduce the effect of diuretics and other high blood pressure medications. Therefore, the lowering effects of Angiotensin II receptor antagonists may be impaired by NSAIDs, including COX-2 selective inhibitors.

In some patients with renal dysfunction, it has been treated with non-steroid anti-inflammatory drugs, including cyclooxygenase-2 inhibitors, simultaneous use of Angiotensin II receptor antagonists can lead to further impairment of kidney function. These effects are usually recovered when taking the drug.

hydrochlorothiazid:

When coordinated, the following drugs may interact with the diuretics: Alcohol, Barbiturat or addictive drugs: To worsen side effects of lowering posture.

Hemodias (insulin and oral medications): Need to adjust the dose of hypoglycemic drugs.

Other hypertension medications: Agreement effects.

Cholestyramin and Colestipol plastic: reduce the absorption of hydrochlorothiazid when the anion exchange surface is available. The single dose of cholestyramin or Colestipol plastic combined with hydrochlorothiazid and reduces the absorption of thiazid through the gastrointestinal tract in the order of 85% and 43%.

corticosteroids, ACTH: increase power outages, especially hypokalemia.

Amines that cause vascular contractions (such as adrenalin): may reduce the response to the amines as a circuit, but not enough basis to stop using.

Non -reducing muscle relaxants (such as tuboCurarin): may increase response to muscle relaxants.

Lithium: The diuretics reduces the kidney's clearance with lithium and creates a high risk of lithium toxicity, so it should not be coordinated. Read the lithium manual carefully before using these preparations.

Non-steroid anti-inflammatory (NSAID) including cyclooxygenase-2 inhibitors: In some nonsteroidal anti-inflammatory users, including cyclooxygenase-2 inhibitors, which will reduce the effect of thiazid on diuretic benefits, sodium discharge and hypertension.

Interaction with laboratory tests:

Due to the effect of converting calcium, Thiazid has interactive with tests on parathyroid function.