Losartan Stada 50mg tablets treat hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Losartan

Ingredient

Composition information	Content
Losartan	50mg

Uses

indications

Losartan Stada 50 mg is indicated in the following cases:

Hypertension, especially in patients with coughs when taking enzyme inhibitors Angiotensin and reduces the risk of sudden duct in patients with left ventricular hypertrophy.

Kidney disease in patients with diabetes (serum creatinine between 1.3 - 3.0 mg/dl in patients 60 kg and proteinuria). Its activity prevents vascular contraction and aldosteron secretion of angiotensin II by selecting the cohesion between Angiotensin II and AT1 receptor in many tissues (for example: blood vessel smooth muscle, adrenal glands).

Metabolic substances are more active than Losartan from 10 to 40 times according to weight and is a non -competitive, reversible inhibitor of the AT1 receptor.

Both Losartan and its active metabolites do not inhibit ACE (Kininase II, Angiotensin I into angiotensin II and break down Bradykinin), they also do not bond or prevent receptors of other hormones or ion channels that play an important role in regulating the cardiovascular system.

Dynamic pharmacokinetics

Losartan is easily absorbed through the gastrointestinal tract when taken but significantly metabolized through the liver for the first time, leading to the bioavailability of the whole body is only about 33%. It is converted into metabolites that have the activity of carboxylic acid derivative of E - 3174 (exp - 3174), which has a stronger pharmacological activity than Losartan; Some non -active metabolites are also formed. The metabolism mainly due to the isenzyme of Cytochrom P450 is CYP2C8 and CYP3A4. After a dose of oral, the peak concentration of Losartan's plasma is achieved within 1 hour and E -3174 is reached in the range of 3-4 hours.

Both Losartan and E - 3174 are more than 98%of plasma proteins. Losartan is excreted in urine and in the stool through the bile duct in a constant form and the form of metabolites. After drinking, about 4% of the dose is excreted in the form of constant and about 6% excreted in the form of metabolites that are active in urine. The half -life of Losartan is about 1.5 - 2.5 hours and of E - 3174 is about 3 - 9 hours.

Before taking Losartan Stada 50mg tablets treat hypertension (3 blisters x 10 tablets)

How to use

Losartan Stada 50 mg oral.

Dosage

Hypertension

Adults

The common dose is 50 mg x 1 time/day. If necessary, the dose can be increased by 100 mg once a day or divided into 2 times/day. The maximum hypotension effect is achieved after the beginning of treatment is about 3-6 weeks.

The starting dose of 25 mg x 1 time/day is used for patients to reduce the volume of intravascular fluid. This dose is also suitable for patients with liver or renal failure.

Children

From 6 years of age and older with hypertension with the starting dose of 0.7 mg/kg x 1 time/day, up to 50 mg, adjust the dose depending on the degree of response; The dose is higher than 1.4 mg/kg or 100 mg/day has not been studied.

kidney disease in type 2 diabetics

The starting dose of 50 mg x 1 time/day, an increase of the dose to 100 mg x 1 time/day depending on the response on blood pressure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? The most common manifestation of overdose is hypotension and tachycardia; Slow heart rate can also occur due to sympathetic nerve stimulation (vagus nerves).

If symptomic hypotension occurs, it is necessary to conduct supportive treatment measures. Can not remove Losartan or metabolites that are active by hemolysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Losartan Stada 50 mg, you may experience unwanted effects (ADR).

The unwanted effect of Losartan is usually mild and occasionally including dizziness, headache, hypotension standing in the dose.

Hypotension may occur, especially in patients with a decrease in internal fluid volume (for example, high -dose diuretic users).

Rarely contemplating kidney function, rash, urticaria, itching, angioedema and increasing liver enzyme index.

hyperkalemia, muscle pain, and joint pain.

Losartan is less cough than other angiotensin transferring inhibitors.

Other side effects: respiratory disorders, back pain, digestive disorders, fatigue and neutropenia.

Rare syndrome.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Losartan Stada 50 mg is contraindicated in the following cases:

Patients with hypersensitivity to Losartan Kali or any ingredient of the drug.

Be cautious when using

Caution to use Losartan in patients with kidney stenosis.

Losartan is excreted in urine and in the bile duct, so the dose should be reduced in patients with renal failure and should be considered for patients with liver failure.

Patients with reduced internal fluid volume (for example, high -dose diuretic users) may occur hypotension; Should adjust the status of the internal fluid before taking the drug, or the starting dose is low.

Due to hyperkalemia, monitoring of special serum levels should be monitored in older adults, patients with renal impairment, and should be avoided simultaneously with potassium diuretics.

The ability to drive and operate machinery

There has been no research on reactions on the ability to drive and operate machinery. However, when driving or operating machinery must pay attention to dizziness and drowsiness can sometimes occur when treating hypertension, especially when starting treatment or when increasing the dose.

Pregnancy

When used in the second and third quarter of pregnancy, drugs that work directly on the Renin - Angiotensin system may cause damage, even death for the developing fetus. Stop using Losartan as soon as possible when detecting pregnancy.

The period of breastfeeding

Due to the harmful effects for breastfeeding babies, it is necessary to decide whether to stop breastfeeding or stopping the drug, depending on the importance of the drug for the mother.

Drug interaction

In studies on drug interaction, there is no significant pharmacokinetic interaction between losartan and hydrochlorothiazid, digoxin, warfarin, cimetidine and phenobarbital.

Rifampin, a drug metabolic agent, reduces the level of losartan and its active metabolites.

Fluconazole, a P450 2C9 inhibitor agent, reduces the concentration of active metabolites and increases the level of Losartan.

Like Angiotensin II blockers or its effects if used simultaneously with potassium diuretics (such as Spironolacton, Triamteren, Amilorid), with potassium supplements, or salt -containing salt substitutes, it can lead to serum hyperpass.

As well as other hypertension drugs, losartan's anti -hypertension effect may be reduced when using indomethacin, an non -steroid anti -inflammatory drug.

Storage

Storage in closed packaging, dry place, avoid light.

Temperature does not exceed 30 ° C.

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