Losartan tablets 25mg Domesco treat hypertension, reduce cardiovascular disease (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Losartan

Ingredient

Composition information	Content
Losartan	25mg

Uses

Indications

Losartan 25mg is indicated in the following cases:

Treatment of hypertension. (Type AT1) Angiotensin II.

angiotensin II, made up of angiotensin I in the reaction due to the catalytic enzyme (ACE), is a strong vascular contract; It is the main hormone that activates the Renin-Anotensin system and is an important component in the pathophysiology of hypertension. Angiotensin II also stimulates the adrenal glands of Aldosteron.

Losartan and the main metabolites have a clogged and aldosteron secretion of angiotensin II by preventing Angiotensin II selectively, not attaching to the AT1 receptor in many tissues (for example, blood vessel muscles, adrenal glands). In many tissues, there is also an AT2 receptor but it is unclear whether this receptor has nothing to do with the cardiovascular air conditioner. Both Losartan and the main active metabolites do not show the local dominant effects in the AT1 receptor and have a much larger AT1 receptor affinity (about 1,000 times) than the AT2 receptor.

Losartan is a competitive, reversible inhibitor of the AT1 receptor. The metabolic substance has the activity of drugs 10 to 40 times stronger than Losartan, calculated by weight and is a non -competitive, reversible inhibitor of the AT1 receptor. Angiotensin II antagonists also have hemodynamic effects such as ACE inhibitors, but there is no unwanted effect of the common ACE inhibitors are dry cough.

pharmacokinetics

After drinking, Losartan absorbs well and initially metabolized through the liver thanks to the cytochrom P450 enzymes. Losartan's bioavailability is approximately 33 %. About 14 % of losartan dose taken into active metabolites, this substance is mostly opposing the Angiotensin II receptor resistance. Losartan waste sale time is about 2 hours and of metabolites for 6-9 hours. The average peak concentration of Losartan reaches within 1 hour and of the metabolites with activity within 3-4 hours.

Losartan and active metabolites are highly linked to plasma proteins, mainly albumin and they do not go through blood -brain barriers. Losartan's distribution volume is about 34 liters and of metabolites with an activity of about 12 liters. The total clearance of Losartan's plasma is about 600ml/minute and of the active metabolites of 50ml/minute; Their clearance in the kidney corresponds to about 75ml/min and 25ml/min. After drinking Losartan marked 14C, collected about 35 % of the radioactive in the urine and about 60 % in feces.

In patients with mild to medium cirrhosis, the area under the curve (AUC) of Losartan and of the metabolic substance is more active, 5 times and 2 times more than the patient with normal liver.

Before taking Losartan tablets 25mg Domesco treat hypertension, reduce cardiovascular disease (1 blister x 10 tablets)

How to use

use oral, can drink losartan when hungry or full.

Dosage

Dosage depending on the patient and must adjust the dose according to the blood pressure response. If the blood pressure is not controlled at the dose used, every 1-2 months must adjust the dosage of anti -hypertension drugs.

Initial and maintained dose for most patients is 50mg, taken once a day. The maximum effect of treating hypertension reaches 3-6 weeks after starting the medication. Can increase the dose to 100mg, once a day.

For patients with a decrease in the volume of circulatory fluid (for example, the person who treats high doses of doses) should consider the starting dose of 25mg, once a day.

No need to adjust the starting dose for elderly patients or kidney failure, including people who are hemolysis. Need to consider lower doses for patients with a history of liver failure.

If using losartan alone without controlling blood pressure, adding low doses of dosage. Hydrochlorothiazid proves to have a plus effect. Losartan can be used with other anti -hypertension drugs. Do not coordinate Losartan with potassium -keeping diuretic drugs due to the risk of hyperkalemia.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? The most possible manifestation of overdose is possible is hypotension and tachycardia, which can also occur slowly due to stimulation of sympathetic nerve (vagus nerve). If symptomatic hypotension occurs, it is necessary to take supportive treatments.

Cannot remove Losartan and metabolites still active of Losartan by dialysis.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Losartan 25mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Hypotension, insomnia, dizziness, hyperkalemia, diarrhea, indigestion, mild hemoglobin and hematocrit, back pain, leg pain, muscle pain, hypoglycemic acid (when taking high doses), cough (less when using ACE inhibitors), nasal congestion, sinusitis.

Uncommon, 1/1000

Standing blood pressure, chest pain, block II block, chest drum, sinus rhythm, tachycardia, face, blush, anxiety, loss of air conditioning, confusion, depression, migraine, headache, sleep disorders, fever, dizziness, hair loss, dermatitis, dry skin, red rash, light sensitivity, itching, urticaria, bruises, gout, gout, gout Force, sex reduction, urination, night urine, slight increase of liver function tests and slight increase bilirubin, paresthesia, tremor, bone pain, muscle weakness, joint edema, fibroid pain, blurred vision, conjunctivitis, vision loss, burning and eye pain, tinnitus, urinary tract infections, slight increase in creatinine or urea, shortness of breath, nose inflammation, nose and nose inflammation foul.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Losartan drug 25mg Contraindications in the following cases:

Hypersensitivity to any ingredients of the drug.

Precautions when using

sensitivity: eagle.

Hypotension and imbalance, electrolyte: In patients with a volume of circulatory fluid (such as a high -dose dosage treatmenter), symptomic hypotension may occur. These conditions must be adjusted before taking the drug, or the starting dose must be lower. Electrolyte imbalance is common in patients with kidney failure, with diabetes or not.

Liver failure: Based on pharmacokinetics data, there has been an increase in Losartan levels in plasma in patients with cirrhosis, which should be considered lower doses for patients with a history of liver failure.

Renal failure: As a result of inhibiting the Renin - Angiotensin system, there has been reports on changes in kidney function, including kidney failure in sensitive people, these changes in kidney function can recover when stopping the drug.

Use of children: For children who can swallow the pills, the recommended dose is 25mg x 1 time/day in patients with severe patients ≥ 20kg to 50kg, the starting dose is 50mg, once a day, can increase the dose up to 100mg, once a day. Before taking children's drugs, it is advisable to adjust the circulatory volume reduction. It is not recommended to use drugs in children with glomerular filtration

The ability to drive and operate machinery

Caution when driving and operating machinery because the drug can cause dizziness, weakness, fatigue and dizziness.

Pregnancy

Use drugs that work directly on the Renin - Angiotensin system in the middle and last three months of pregnancy can cause less amniotic fluid, hypotension, urinary, dawn, face deformity and death in infants. Although the use of drugs in the first three months of pregnancy has not seen the risk of the fetus, but after detecting pregnancy, Losartan must be stopped as soon as possible.

Breastfeeding period

It is unknown whether Losartan is secreted into breast milk or not, but there are significant amounts of Losartan and metabolites whether the drug's active in mice milk. Due to harmful potential for breastfeeding, deciding to stop breastfeeding or stopping the drug, taking into account the importance of the drug for the mother.

Drug interaction

Losartan in collaboration with cimetidine increases the area under the curve (AUC) of Losartan by about 18%, but does not affect the pharmacokinetics of the active metabolites of Losartan.

Losartan combined with phenobarbital reduces about 20% of Losartan and of active metabolites.

Potassium -keeping pills (such as Spironolacton, Triamteren, Amilorid), Potassium supplements, salt -containing salt substitutes, are not in combination with Losartan because of the risk of hyperboly in serum.

The effect of reducing blood pressure may be reduced when combined with nonsteroidal anti -inflammatory drugs.

Storage

In a dry place, temperatures below 30 degrees Celsius, avoiding light.

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