Losartan tablets 25mg TV.Pharm treat hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Losartan

Ingredient

Composition information	Content
Losartan	25mg

Uses

indicated

losartan indicated in the following cases:

Treatment of hypertension, can be used alone or in combination with other hypertension medications.

Angiotensin II, made up of angiotensin I in the reaction of the enzyme switching angiotensin (ACE), is a strong vasoconstriction, which is the main vascular activation hormone of the Renin - Angiotensin system, and is an important component in the pathological physiology of hypertension. Angiotensin II also stimulates the adrenal glands of Aldosteron.

Losartan and main metabolites have the activity that prevents vascular shrinkage and aldosteron secretions of angiotensin II by preventing selective angiotensin II, not attached to the AT1 receptor in many tissues (for example, blood vessel muscles, adrenal glands). Both Losartan and the main active metabolites do not show the local owner's effect in the AT1 receptor and have a much larger AT1 receptor affinity (about 1,000 times) than the AT2 receptor.

Losartan is a competitive, reversible inhibitor of the AT1 receptor. The metabolic substance has the activity of the drug 10 to 40 times stronger than Losartan, calculated by weight and is a non -competitive inhibitor, reversible AT1 receptor door. Angiotensin II antagonists also have hemodynamic effects such as ACE inhibitors, but there is no unwanted effect of the common ACE inhibitors are dry cough.

Pharmacokinetics

absorption

After drinking, Losartan absorbs well and initially metabolizes the liver thanks to the cytochrom P450 enzymes.

Distribution

Biology of iOSartan is approximately 33%. Both Losartan and active metabolites are linked to plasma proteins, mainly albumin and they do not go through blood -brain barriers. The distribution of Losartan is about 34 liters and of the metabolites with an activity of about 12 liters.

Metabolism

About 14% of Losartan oral oral transformed into active metabolites, this substance is responsible for a great part of Angiotensin II receptor countervailing.

Elimination

The half -life of Losartan elimination is about 2 hours, and of the metabolite for about 6-9 hours. The average peak concentration of Losartan Dat within 1 hour, and the metabolites are active within 3-4 hours.

Losartan's total plasma clearance is about 600ml/minute and of an active metabolite of 50ml/minute; Their clearance in the kidney corresponds to about 75ml/min and 25ml/min. After taking Losartan to play 14C, collect about 35% of the radioactive in the urine and about 60% in the feces.

Before taking Losartan tablets 25mg TV.Pharm treat hypertension (3 blisters x 10 tablets)

How to use

Losartan 25mg oral drug.

Dosage

Dosage depending on the patient and must be adjusted according to the blood pressure response.

Starting dose: Take 1 dose of 500 mg/day.

Patients are likely to lose fluid in the heart (users of diuretic drugs), liver failure:

Starting dose: 25 mg/day.

Maintenance dose: 25 - 100 mg/day. Depending on the blood pressure response of the patient.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? The most common manifestation of overdose is probably hypotension and tachycardia, which may also experience slow heart rate due to sympathetic nervous stimulation (vagus nerve).

If symptomic hypotension occurs, supportive treatment must be treated. Both Losartan and metabolites are active, they cannot be removed by hemolysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

Cardiovascular: lower blood pressure.

Central nerve: insomnia, dizziness.

Endocrine - Metabolism: hyperkalemia.

digestive: urine, indigestion.

Hematology: Light hemoglobin and hematocrit.

Neuropathy - bone: back pain, leg pain, muscle pain.

Kidney: lower blood uric acid (when taking high doses).

Respiratory: cough (less when using ACE inhibitors), nasal congestion, sinusitis.

Uncommon, 1/1000

Cardiovascular: Hypotenia Hematuria, chest pain, Block A - V degree II, chest drum, sinus slow rhythm, tachycardia, facial edema, blushing.

Central nerve: anxiety, loss of air conditioning, confusion, depression, migraine, headache, sleep disorders, fever, dizziness.

Skin: Hair loss, dermatitis, dry skin, erythema, light sensitivity, itching, urticaria, bruises, foreign rash.

Endocrine - Metabolism: gout.

Digestive: Anorexia, constipation, flatulence, vomiting, loss of taste, gastritis.

Genital - Urinary: Helpless, reduce sex, urine, urine nights.

Liver: Increase the test of liver function and slightly increase bilirubin.

Neurosurgery: Perception, tremor, bone pain, muscle weakness, joint edema, muscle fibrosis.

Eyes: blurred vision, conjunctivitis, vision loss, burning and eye aches.

ears: tinnitus.

Kidney: urinary tract infections, slight increase in creatinine or urea.

Respiratory: Difficulty breathing, bronchitis, nosebleeds, rhinitis, breathing sugar, uncomfortable in the throat.

Other effects: sweating.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

contraindicated

Losartan 25mg Contraindicated in the following cases:

Hypersensitivity to Losartan or any ingredients of the drug.

Be cautious when using

Special monitoring and /or decreased dose in patients dehydrated, diuretic treatment and patients have other factors that can easily lead to hypotension. Patients with kidney stenosis on both sides or one side, only one kidney is also at high risk of unwanted effects (increased creatinine, blood urea) and should be closely monitored in treatment.

Patients with liver failure must take lower doses.

The ability to drive and operate machinery

Losartan can be stunned, dizzy so it is not used for drivers and machinery.

Pregnancy

Using drugs directly on the Renin - Angiotensin system in the middle and last three months of pregnancy can cause less amniotic fluid, hypotension, anuria, urinary, face deformation and death in infants. Although, the use of drugs in the first three months of pregnancy has not seen the risk of the fetus, but after detecting pregnancy, it is necessary to stop iosartan as soon as possible

The period of breastfeeding

It is not known whether Losartan will be secreted into breast milk or not, but there are significant amounts of Losartan and metabolites whether the drug's activity in mouse milk. Due to harmful potential for breastfeeding, deciding to stop breastfeeding or stopping the drug, taking into account the importance of the drug for the mother.

Drug interaction

Losartan does not affect the pharmacokinetics of Digoxin oral or intravenously.

Take iosartan along with cimetidine increases the area under the curve (AUC) of Losartan by about 18%, but does not affect the pharmacokinetics of the active metabolites of Losartan.

Take Losartan along with Phenobarbital reduces about 20% of Losartan's AUC and of active metabolites.

There is no pharmacokinetic interaction between losartan and hydrochlorothiazide.

Storage

Store in a dry place, not more than 30 ° C, avoid light.

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