Losatec H 50mg RPG treatment for hypertension (3 blisters x 10 tablets)
Dosage form Box of 3 blisters x 10 tablets
Specifications Losartan, hydrochlorothiazide
Ingredient
| Composition information | Content |
| Losartan | 50mg |
| Hydrochlorothiazide | 12.5mg |
Uses
indications
losatec h drugs are indicated in the following cases:
losartan-hydrochlorothiazide
Two components of Losartan and hydrochlorothiazid have shown an impact on hypotension, reducing blood pressure at a higher level than just one of the two components. This effect is thought to be the result of the natural effects of both components.
Moreover, due to its diuretic effect, hydrochlorothiazid increases the lenin activity in serum, increases aldosteron secretion, reduces serum potassium, and increases angiotensin II concentration. Losartan's mechanism prevents all related physiological activities of Angiotensin II and through Aldosteron inhibitors can reduce potassium loss related to diuretics.Losartan has been shown to increase uric acid in mild and transient urine, hydrochlorothiazid has been shown to increase mild blood uric acid, the combination of Losartan and hydrochlorothiazid tends to reduce hyper uric acid in blood caused by diuretics.
Losartan/hydrochlorothiazide is extended for about 24 hours. In clinical studies that last for at least 1 year, the hypotension effect is maintained when continuing to use the drug.
Despite significantly reducing blood pressure, the use of Losartan/Hydrochlorothiazide does not have a significant clinical impact on the heart rate. In clinical trials, after taking the drug at the dose of Losartan 50 mg Hydrochlorothiazide 12.5 mg for 12 weeks, the lowest diastolic blood pressure level is reduced by an average of up to 13.2 mmHg.
losartan/hydrochlorothiazid is effective in reducing blood pressure in men and women, black and black and white people, in young patients ( 65 years) and is effective at all levels of hypertension.
losartan
Losartan is an anti-synthetic Angiotensin-II receptor (AT1 type). Angiotensin II, a strong vascular substance, is the main active hormone of the Renin-Anotensin system and is an important decisive factor for the pathophysiology of hypertension.
Angiotensin II associated with the AT1 receptor is found in many tissues (for example, blood vessel muscles, adrenal glands, kidneys and heart) and produce important biological effects, including vasoconstriction and release aldosteron. Angiotensin II also stimulates smooth muscle cell proliferation.
hydrochlorothiazide
hydrochlorothiazid is a thiazid diuretic. The mechanism of hypotension of thiazid diuretics has not been fully known. Thiazid affects the mechanism of electrolyte reabsorption of the renal tubules, directly increasing the excretion of sodium and chloride in the same amount.
Diuretic effects of hydrochlorothiazid reduces serum volume, increases serum renin activity and increases aldosteron secretion, thus increasing potassium in urine and loss of bicarbonate and reducing serum potassium. Angiotensin II receptors intermediate the impact of the Renin-Lostosteron system and so the sharing of Angiotensin II receptor antagonist tends to reduce the loss of potassium associated with thiazid diuretics.
After oral use, diuretics start within 2 hours, peaks for about 4 hours and lasts about 6 to 12 hours, the effect of hypotension lasts up to 24 hours.
Pharmacokinetics
absorption
After drinking, Losartan is well absorbed and undergone the first metabolism process, forming a metabolite of carboxylic acid and active substances and other non -active substances. Losartan's whole body bioavailability is about 33%.
The average peak concentration of Losartan and its active metabolites achieved in 1 hour and for 3-4 hours. There is no significant clinical difference in plasma concentration when the drug is taken with a standard meal.
Distribution
Losartan: Both Losartan and active metabolites have a ratio of plasma proteins> 99%, mainly albumin. The distribution of Losartan is 34 liters. Rat research shows that the amount of Losartan passes through a very low brain barrier.
Hydrochlorothiazide: Hydrochlorothiazide passes through the placenta, but does not pass through the bloodstream barrier and is excreted into breast milk.
Birth
losartan:
About 14% of intravenous or oral dose is metabolized into active metabolic form.
After taking or injection of Losartan Kali marks a 14C radioactive circulation in plasma, mainly due to Losartan and its active metabolites. The minimum metabolism of Losartan into active metabolites has been observed in about one percent of the number of patients studied.
Along with active metabolites, non-active metabolites are formed, including two main metabolites formed by hydroxylation of the Butyl chain and an auxiliary metabolic, Tetrazole Glucuronide N-2.
Elimination
losartan:
Losartan's plasma clearance and metabolites have the corresponding activity of about 600 ml/min and 50 ml/min. The kidney clearance of Losartan and metabolites is active as about 74 ml/min and 26 ml/min.
After oral use, about 4% of the dose is eliminated in the form of non -metabolic and about 6% of the doses are eliminated in the urine in the form of active metabolism. The pharmacokinetics of Losartan and its active metabolites are linearly with the oral Losartan dose of oral up to 200 mg.
After drinking, Losartan's plasma concentrations and active metabolites have decreased many times with the final semi -exhaust time of about 2 hours and 6 - 9 hours respectively.
After a dose of 100 mg once a day, both Losartan and its active metabolites are not significantly accumulated in plasma.
Losartan and its metabolites are eliminated through bile and urine.
After taking a dose of Losartan marked 14C in men, about 35% of radioactive material is found in urine and 58% found in feces.
hydrochlorothiazide:
Hydrochlorothiazide is not metabolized but is quickly excreted through the kidneys. When the plasma drug concentration is monitored for at least 24 hours, the duration of plasma is observed in the range of 5.6 to 14.8 hours. At least about 61% of oral drugs are eliminated in the form of non -metabolic within 24 hours.
Before taking Losatec H 50mg RPG treatment for hypertension (3 blisters x 10 tablets)
How to use
Losartan Kali/Hydroclorothiazid can be used with other hypertension medications.
Losartan Kali/Hydroclorothiazid should be swallowed with a cup of water.
Losartan Kali/Hydrochorothiazid can be used with food or not.
Dosage
Dosage of hypertension treatment:
Losartan and hydrochlorothiazid are not used as the original therapy, but used in patients with blood pressure is not well controlled just by Losartan Kali or hydrochlorothiazide.
recommend that the drug should be standard for each separate ingredient (Losartan and hydrochlorothiazid).
When clinically appropriate, patients with untreated blood pressure can be considered directly from single -treatment therapy to coordinated therapy.
The common maintenance dose of Losartan Kali/Hydrochorothiazid is a Losartan potassium 50mg/hydrochlorothiazide 12.5 mg (Losartan 50 mg/HCTZ 12.5 mg) once/day.For patients who do not respond well to Losartan Kali 50mg/Hydroclorothiazid 12.5 mg, the dose may increase to a Losartan potassium 100mg/hydrochlorothiazid 25 mg (Losartan 100 mg/HCTZ 25 mg) once a day.
The maximum dose is a Kali potassium tablet 100mg/hydrochlorothiazide 25mg once a day. In general, the effect of hypotension is achieved within three to four weeks after the beginning of treatment.
Patients with kidney failure and patients with hemolysis:
Patients with intravascular volume decline: The volume or decline in sodium must be adjusted before taking Losartan/HCTZ.
Older patients: The adjustment of the dose is usually not necessary for the elderly.
Children: Used in children and adolescents (
There is no experience in children and teenagers. Therefore, losartan hydrochlorothiazide should not be used for children and adolescents.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do
do when overdose? Symptomatic treatment and support. Losartan Kali/hydrochlorothiazid should be stopped and closely monitor patients. Proposal solutions include vomiting if the new patient takes medication recently and adjusted dehydration, electrolyte imbalance, liver coma and hypotension by appropriate measures.
losartan
There is a limited data on overdose in humans. The usual expression of overdose will be lowering blood pressure and tachycardia; Slow heart rate can occur due to an irritation. If symptoms of hypotension appear, support should be supported. Both Losartan and active metabolites cannot be removed by hemorrhage.
hydrochlorothiazide
The most common signs and symptoms are observed as symptoms due to electrolyte loss (hypotension, hypoglycemia, hypoglyc sodium) and dehydration due to excessive diuretic. If the digitalis is also used, hypokalemia can seriously cause arrhythmia. The level of hydrochlorothiazid is removed by unknown hemorrhage.
What to do when forgetting 1 dose?
Not recorded.
Side Effects
When using Losatec H, you may experience unwanted effects (ADR).
losartan
Blood and lymphatic disorders:
immune system disorders:
Nutrition and metabolic disorders:
Mental disorders:
Ear and ear disorders:
Heart disorders:
Vascular disorders:
Skin and subcutaneous tissue disorders:
hydrochlorothiazide
Blood disorders and lymphatic systems:
immune system disorders:
Nutrition and metabolic disorders:
Mental disorders:
Nervous system disorders:
Eye disorders:
Vascular disorders:
Gastrointestinal disorders:
Skin disorders and structure under the skin:
When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Losatec H Pills contraindicated in the following cases:
2nd and 3rd pregnancy. Severe renal failure (creatinine clearance Losartan Tharma. Patients with a history of angioedema (swelling of the face, lips, throat, or tongue) should be closely monitored. Hypotension and decreased internal volume. Symptomic hypoglycemia, especially after the first dose, can occur in patients with a decrease in volume or reduce sodium due to being treated with strong diuretic, diet that limits salt, diarrhea or vomiting. Such cases should be adjusted before using Losartan Kali Tablets 50mg/Hydrochlorothiazide 12.5mg. Electrolyte imbalance: The common electrolyte imbalance in patients with renal failure, with or without diabetes should be noted. Therefore, the concentration of potassium and creatinine clearance should be closely monitored; Especially in patients with heart failure and creatinine clearance from 30-50 ml/minute to be closely monitored. It is not recommended to simultaneously use potassium -saving diuretic, potassium supplements and replacement salt containing potassium and losartan hydrochlorothiazide. Effect on the liver: Based on dynamic pharmacokinetics, the losartan concentration in serum increases significantly in cirrhosis patients, so they should be cautious when using Losartan Kali Hydroclorothiazide in patients with a history of mild to medium liver failure. Renal function decline: The consequences of inhibiting the Renin-Anotensin-Aldosteron system, changes in renal function, including renal failure, has been reported (especially in patients with renal function depending on the renin-angiotensin-irtosteron system, including patients with heart failure or history of kidney dyslias). As well as other drugs that affect the renin-angiotensin-aldosterone system, increased Urea and serum creatinine have also been reported in patients with kidney stenosis or one-sided kidney stenosis, these kidney function changes can recover when stopped treatment with drugs. Losartan should be used cautiously in patients with kidney stenosis on either side or artery stenosis on one side of a unique kidney. Renal transplantation: There is no experience in treating patients with a history of kidney transplant. primary Aldosteron: Patients with primary Aldosteron generals in general will not respond to hypertension drugs that active through inhibition of the renin-anidensin system. Therefore, the use of potassium/hydrochlorothiazide is not recommended. Coronary artery disease and cerebrovascular disease: Like any lower blood pressure drug, excessive impairment of blood pressure in patients with ischemia and cerebrovascular disease can cause myocardial infarction or stroke. heart failure: In patients with heart failure, with or without kidney failure, as well as other drugs that act on the renin-angiotensin system, the risk of severe hypotension, and normal (acute) kidney failure. Aortic stenosis and mitral stenosis, hypertrophic myocardial disease: Like other vasodilators, special attention should be paid to patients with aortic stenosis or mitral stenosis, or hypertrophic cardiomyopathy. Race difference: As seen in Angiotensin, Losartan and other Angiotensin antagonistic drugs seem less effective in lowering blood pressure in black people than black and white skin, may be due to low ratio of renax in hypertension. Dual inhibitor Renin-Anotensin-Aldosteron (RAAS): There is evidence that the simultaneous use of ACE inhibitors, Angiotensin II or Aliskiren receptor blockers increases the risk of hypotension, hyperkalemia and reduced kidney function (including acute renal failure). Dual inhibitor RAAS through the combination of ACE inhibitors, Angiotensin II or Aliskiren receptor blockers are not recommended. If the dual therapy is considered necessary, this is only done when experts are supervised and must closely monitor kidney function, electrolyte and blood pressure. Do not use ACE inhibitors and Angiotensin II receptor blockers in patients with diabetic kidney disease. hydrochlorothiazide Hypotension and an imbalance of electrolytes: as well as all hypotension, hypotension symptoms may occur in some patients. Patients should follow the clinical signs of fluid or electrolyte imbalance, for example, decreased volume, hypoglycemia, alkalinizing chlorine, hypoglycemia or hypotension may occur while diarrhea or vomiting recurring. Periodic testing of electrolytes in serum should be done in the appropriate time in these patients. Hypoglycemia due to dilution can occur in patients with edema in hot weather. Metabolism and endocrine effects: thiazid may reduce glucose tolerance. The dose of diabetes may be needed, including insulin. Potential diabetes can appear during thiazid treatment. Thiazid may reduce the amount of calcium secretion in the urine and can increase mild and transient blood calcium. Signs of hypercalcemia may be evidence of hidden hyperthyroidism. thiazid should be stopped before performing tests for the parathyroid function. Increase of cholesterol and triglycerides may be related to thiazid diuretics. Thiazid may increase blood uric acid precipitate or gout in some patients. Because Losartan reduces uric acid, Losartan combines with hydrochlorothiazid that reduces the increase in blood uric acid levels due to diuretics. excipients: Losartan Kali/hydrochlorothiazid contains lactose. Patients with rare genetic problems such as galactose intolerance, lactase deficiency or Glucose-Galactose should not take this drug. There is no research on the effects on the ability to drive and use machines. However, when driving or operating machinery, it must be remembered that dizziness or drowsiness can sometimes occur when treating hypotension, especially when starting treatment or when increasing the dose. using Angiotensin II receptor antagonistic drugs is not recommended in the first 3 months of pregnancy. Use Angiotensin II receptor antagonistic drugs in the middle and late pregnancy. Epidemiological evidence about the risk of teratogenicity after taking ACE inhibitors in the first 3 months of pregnancy has not yet been concluded, but it is not possible to rule out an increase in risk. Although there is no controlled epidemiological data on the risk of Angiotensin II receptor antagonist (Allras), similar risks may occur for this group of drugs. Caution when using
The ability to drive and operate machinery
Pregnancy
Use Losartan Kali/Hydroclorothiazide in the middle of the three months and the end of pregnancy causing human toxicity (impaired renal function, reduced amniotic fluid, skull retardation) and newborn toxicity (kidney failure, hypotension, hyperkalemia).
If you have taken Losartan Kali/Hydrochlorothiazide in the second quarter of pregnancy, the ultrasound is to check the kidney and skull function.
Babies whose mothers use Losartan/Hydrochlorothiazide should be closely monitored with the ability to lower blood pressure.
There is little experience in using hydrochlorothiazide in pregnant women, especially in the first three months of pregnancy. Animal studies are incomplete.
Hydrochlorothiazide passes through the placenta fence. Based on the pharmacological mechanism of hydrochlorothiazide, if taking the drug throughout the second and third quarter of pregnancy can be transmitted between the mother and the fetus can cause effects on the fetus and infants such as jaundice, electrolyte balance disorders and platelets.
Hydrochlorothiazide should not be used for patients with fetal edema, pregnancy hypertension or pre -eclampsia due to the risk of decreased plasma volume and reducing blood pressure in the placenta, without beneficial effects during treatment.
Do not use hydrochlorothiazide for primary hypertension in pregnant women except rare cases without any other treatment.
The period of breastfeeding
There is no information on the use of potassium/hydrochlorothiazide losartan during breastfeeding.
hydrochlorothiazid is excreted in breast milk. Therefore, the use of potassium/hydrochlorothiazid losartan during breastfeeding is not recommended. Alternative treatments with safety records are better established during breastfeeding, especially while taking care of newborn or premature babies.
Drug interaction
Losartan
rifampicin and fluconazole are reported to reduce the concentration of active metabolites. The clinical consequences of this interaction are not evaluated.
As well as with Angiotensin II blockers or its effect, simultaneous use of potassium -saving diplomatic (e.g. spironolactone, triamterene, amiloride), potassium supplements, or alternative salt containing potassium can increase potassium levels in blood. Simultaneous use is not recommended.
As with other drugs that affect sodium elimination, lithium elimination may be reduced. Therefore, lithium concentration should be strictly controlled if Lithium salt is used simultaneously with Angiotensin II receptor blockers.
When Angiotensin II receptor antagonists are used simultaneously with NSAIDs (e.g. selective inhibitors of COX-2, acetylsalicylic acid at the level of anti-plateletic dosage) and non-selective NSAIDs, the impaired impairment of hypotension may occur.
The simultaneous use of Angiotensin II anti -diuretics or diuretics and NSAIDs can lead to an increased risk of renal function, including acute renal failure that may occur, and increase blood potassium concentration, especially in patients who have poor kidney function before. Should be cautious when combining drugs, especially on the elderly. Patients should be provided with adequate water and consider monitoring of the kidney function after starting to coordinate the drug and periodically.On some patients with renal function damage that are treated with NSAIDs, including the selective inhibitors of COX-2, simultaneously used with Angiotensin II receptor resistant drugs may impair renal function. These effects are usually recovered later.
Other drugs that have antihypertensive effects such as three -round antidepressants, psychotic drugs, baclofene, amifostine: simultaneous use with these drugs that reduce blood pressure, such as the main effect or side effects, can increase the risk of lowering blood pressure.
Data on clinical trials shows that the Renin-Anotensin-Andosterone (RAAS) dual blocker is through the use of ACEI drugs, Aniotensin II or Aliskiren receptor blockers are related to higher side effects such as lowering blood pressure, hyperboly hyperpoints and renal function impairment (including acute renal impairment) compared to the use of drugs that act on the use of drugs. Raas.
hydrochlorothiazide
When used simultaneously, the following drugs can interact with thiazide diuretics:
Alcohol, barbiturates, sleeping pills or antidepressants: may occur from a vertical posture.
Diabetes treatment (including oral and insulin drugs): Thiazide diuretic treatment may affect glucose tolerance. The dose of diabetes can be adjusted. Metformin should be used carefully because there is a risk of lactic acidosis due to kidney failure may occur related to hydrochlorothiazide.
Other medications for hypertension: Increasing side effects.
Cholestyramine and Colestipol plastic: may impair the absorption of hydrochlorothiazide due to the presence of ion exchange resin. The single dose of cholestyramine or Colestipol plastic is linked to hydrochlorothiazide, reducing its absorption from the gastrointestinal tract, up to 85% and 43%.
corticosteroids, ACTH: Reduce electricity, especially hypokalemia.
Amines of hypertension (eg Adrenaline): The ability to react decreases for amines caused but not significant to stop using the drug.
Muscle relaxants, non -reducing pipes (for example, tutocurarine): may increase in response to muscle relaxants.
Lithium: Diuretics reduce lithium release through the kidneys and increase the risk of lithium toxicity; Not recommended to use simultaneously.
Medicinal products used in the treatment of gout (probenecid, sulfinpyrazone and allopurinol): Need to adjust the dosage of urinary -excreted products for hydrochlorothiazide acid that can increase the concentration of serum uric acid. Increased dose of probenecid or sulfinpirazone may be necessary. Simultaneous use of Thiazide can increase the hypersensitive reaction rate for allopurinol.
Cholinergic anti -cholinergic (e.g. atropine, biperiden): enhanced bioavailability for thiazid diuretics by reducing gastric gastric motility and gastric empty removal rate.
Cyclophosphamide, methotrexate): Thiazid): Thiazid can reduce the excretion of cytotoxic substances through the kidneys and increase bone marrow inhibition effects.
salicylate: In the case of high doses of salicylat, hydrochlorothiazide can increase the toxicity of salicylate on the central nervous system.
Methyldopa: There have been separate reports on hemolytic anemia occurring when using simultaneously hydrochlorothiazide and methyldopa.
Cyclosporine: Concomitant treatment with cyclosporine may increase the risk of hyperuricemia and complications of gout.
Digitalis glycosides: Hemoto reduction or hypoglycemia caused by thiazide diuretics can help the onset of digitalis arrhythmia.
Medicinal products affected by blood potassium disorders: periodic monitoring of blood potassium and ECG concentration is recommended when Losartan/Hydrochlorothiazide is used simultaneously with drugs affected by blood potassium disorders (for example, digitals glycosides and anti -arrhythmic drugs) and followed by torsion (left ventricular tachycardia) caused by some drug products (including a number of anti -pesticide drugs) is a factor leading to twisting nails (left ventricular tachycardia):
Anti -arrhythmia type III (for example: amiodarone, sotalol, dofetilide, ibutilide).
Calcium salts: Thiazid diuretics may increase serum calcium concentration due to excretion reduction. If you need to supplement calcium, you need to monitor serum calcium levels and adjust the dose of calcium accordingly.
Laboratory interaction: Because of the effects on calcium metabolism, Thiazides can interfere with tests on parathyroid function.
Carbamazepine: The risk of symptoms of sodium hypothermia. Clinical and biological monitoring.
Iodine contrast: In case of dehydration caused by diuretics, the risk of acute renal failure increases, especially when using high doses of iodine -containing products. Patients should be granted sufficient epidemics before taking the drug.
amphotericin B (digestive tract), corticosteroid, acth laxative, or glycyrrhizin (included in licorice): hydrochlorothiazide can increase electrolyte imbalance, especially hypoemia.
Storage
Store at a temperature of less than 300C, in the original packaging to avoid light and moisture.
Other drugs
- ANETHAINE CREAM
- Mixtard
- NEOMERCAZOLE 5MG TABLETS
- PAEDIATRIC PARACETAMOL ELIXIR BP
- Resolor
- ZADITEN TABLETS 1MG
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Popular Keywords
- metformin obat apa
- alahan panjang
- glimepiride obat apa
- takikardia adalah
- erau ernie
- pradiabetes
- besar88
- atrofi adalah
- kutu anjing
- trakeostomi
- mayzent pi
- enbrel auto injector not working
- enbrel interactions
- lenvima life expectancy
- leqvio pi
- what is lenvima
- lenvima pi
- empagliflozin-linagliptin
- encourage foundation for enbrel
- qulipta drug interactions