Lossa 50mg Krka medicine for hypertension (2 blisters x 14 tablets)

Dosage form Box of 2 blisters x 14 tablets
Specifications Losartan

Ingredient

Composition information	Content
Losartan	50mg

Uses

indications

Lossa 50 drugs are indicated in the following cases:

Treatment of hypertension: can be used alone or in combination with other hypertension medications (for example, thiazid diuretics). Losartan should be used for patients who do not tolerate ACE inhibitors.

Losartan is being tested in the treatment of heart failure. This is a great sign of angiotensin receptor antagonism, so it can also be used to treat heart failure as the indications of ACE inhibitors. Losartan Kali also reduces the risk of death from cardiovascular disease, stroke and myocardial infarction in patients with hypertension with left ventricular hypertrophy and protecting kidneys for patients with diabetes with protein.

Pharmacokinetics

absorption

After drinking, Losartan absorbs well. Losartan bioavailability is approximately 33%.

Distribution

both Losartan and active metabolites are highly linked to plasma proteins, mainly albumin and they do not pass the bloodstream barrier. Losartan's distribution volume is about 34 l and metabolites are active about 12 l.

Metabolism

Losartan has initially metabolized through the liver thanks to the cytocrom P450 enzymes. About 14% of the dose of Losartan oral metabolism into active metabolites, this substance is mostly anti -receptor antagonism Angiotesin II.

Elimination

through urine. The clearance of the drug through the kidney corresponds to about 75 ml/minute and with metabolic substances about 25 ml/min.

Before taking Lossa 50mg Krka medicine for hypertension (2 blisters x 14 tablets)

How to use

oral medication. Can drink losartan when hungry or full.

Dosage

Dosage depends on each patient and must be adjusted according to the blood pressure response. The starting dose of Losartan is usually used for adults of 50 mg daily; Lower starting dose may be used (for example, 25 mg per day) for patients who are likely to lose fluid in the heart, including people who are taking diuretics, or liver failure.

Normal maintenance dose is 25 - 100 mg, oral or taken once or divided into 2 times daily. There is no need to change the dose for elderly patients or kidney failure, including people who are hemolysis.

In general, if the blood pressure is not controlled at the dose used, then every 1-2 months to adjust the dosage.

If using losartan alone without controlling blood pressure, can add low -dose dosage, such as hydrochlorothiazid. Losartan can be used with other medications for hypertension. Losartan is not coordinated with potassium diuretics, due to the risk of hyperkalemia.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Hypotension and an abnormal or slow heart rate.

Handling

Stop treatment and monitor patients closely.

If an overdose occurs, mainly treat symptoms and support.

Hemolysis cannot remove Losartan and metabolites that are active from the circulatory round.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

Cardiovascular: lower blood pressure.

Central nervous system: insomnia, dizziness.

Endocrine - Metabolism: hyperkalemia.

digestive: diarrhea, indigestion.

Hematology: Light hemoglobin and hematocrit.

Neuropathy - bone: back pain, leg pain, muscle pain.

kidney: lower blood uric acid (when high doses).

Respiratory: cough (less when using ACE inhibitors), nasal congestion, sinusitis.

Uncommon, 1/1000

Cardiovascular: Hypotenary pressure vertical, chest pain, block A - V degree II, chest drum, sinus slow rhythm, tachycardia, facial edema, blush.

Central nerve: anxiety, loss of air conditioning, confusion, depression, migraine, headache, sleep disorders, fever, dizziness. skin: hair loss, dermatitis, dry skin, erythema, light sensitivity, itching, urticaria, bruises, foreign rash.

Endocrine - Metabolism: gout.

digestive: anorexia, constipation, flatulence, vomiting, loss of taste, gastritis. genital - urinary: Help, sexual reduction, urination, night urine. liver: slightly increase the tests of liver function and slightly increase bilirubin.

Neurosurgery: Perception, tremor, bone pain, muscle weakness, joint edema, muscle fibrosis.

eyes: blurred vision, conjunctivitis, vision loss, burning and eye aches.

ears: tinnitus. kidney: urinary tract infections, slight increase in creatinine or urea.

Respiratory: Difficulty breathing, bronchitis, nosebleeds, rhinitis, airbornment, discomfort in the throat.

Other effects: sweating.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Lossa 50 drug contraindicated in the following cases:

Hypersensitivity to potassium Losartan and other ingredients of the drug.

Be cautious when using

Special monitoring and/or decreased dose in patients dehydrated, diuretic treatment and patients have other factors that can easily lead to hypotension. Patients with kidney stenosis on both sides or one side, only one kidney has a high risk of unwanted effects (increased creatinine and blood urea) and should be closely monitored in treatment.

Patients with lower doses of liver failure.

The ability to drive and operate machinery

Precautions when used for drivers and operating machinery due to drugs with central nervous effects.

Pregnancy

Animal studies with Losartan have shown damage and death on fetus and infant, the mechanism of action is thought to be due to the effect on the renin-analiotensin system. Losartan is contraindicated during pregnancy, should stop using Losartan if pregnant.

Breastfeeding period

It is not known whether Losartan is excreted in breast milk or not. Because many drugs are excreted in milk and due to the likelihood of Losartan's adultery effects on breastfeeding, deciding to stop breastfeeding or stopping the drug depending on the importance of the drug for the mother.

Interactive drug

Losartan's hypotension effect is enhanced when used simultaneously with other hypotension drugs.

Use Losartan simultaneously with drugs that increase potassium such as potassium diuretics, potassium supplements or potassium -containing salts that can cause hyperkalemia.

Losartan is metabolized by the cytochrom P450 enzyme system and can affect the metabolism of some drugs metabolized by these enzymes.

Cimetidine increases the area under the curve (AUC) of Losartan by about 18%. Phenobarbital reduces Losartan levels and active metabolites.

ketoconazole inhibits the transition of losartan into active metabolites.

Use losartan simultaneously with hydrochlorothiazid and digoxin does not show any clinical interactions.

fluconazole is a P450 2C9 inhibitor, so it can increase the concentration and effect of Losartan. In contrast, Rifampin is a liver enzyme induction, thus reducing the concentration of losartan when used simultaneously.

The oral losartan can increase the concentration of lithium by the unknown mechanism. The result is to increase the pharmacological effects and side effects, toxicity of lithium. It is necessary to closely monitor the level of lithium in the process to use simultaneously.

When the porcelain is simultaneously NSAIDs with Losartan, it can lead to impaired renal function, including acute renal failure that may occur especially in the elderly, need to monitor periodic renal function in patients with NSalds and Losartan simultaneously.

Storage

Store in closed packaging, avoid moisture, temperature below 30 ° C.

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