Lostad T25 25mg Stella treats hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Losartan Kali

Ingredient

Composition information	Content
Losartan Kali	25mg

Uses

indications

Lostad T25 drug is indicated in the following cases:

Treatment of hypertension, especially in patients with cough when taking enzyme inhibitors Angiotensin transfer and reducing the risk of stroke in patients with left ventricular hypertrophy. The urinary.

Treatment in case of heart failure and myocardial infarction. kidney).

Metabolic substances are more active than Losartan from 10-40 times by weight and is an non -competitive, reversible inhibitor of the AT1 receptor.

Both Losartan and the active metabolites of the drug are not inhibited ACE (Kininase II, Angiotensin I transferred Angiotensin II and Bradykinin decomposition), they also do not bond or prevent other hormone receptors or ion channels that play an important role in regulating the cardiovascular system.

Pharmacokinetics

absorption

Losartan is easily absorbed through the gastrointestinal tract when taken but significantly metabolized through the liver, resulting in the bioavailability of the whole body only about 33%.

Distribution

Both Losartan and E - 3174 are more than 98%of plasma proteins.

Metabolism

The drug is metabolized into metabolites that have the activity of carboxylic acid derivative E - 3174 (EXP - 3174), which has a stronger pharmacological activity than Losartan; Some non -active metabolites are also formed. The metabolism mainly due to the isenzyme of Cytochrom P450 is CYP2C9 and CYP3A4. After a dose of oral, the peak concentration of Losartan's plasma is achieved within 1 hour and E -3174 is reached in the range of 3-4 hours.

Elimination

Losartan is excreted in the country and in the fertilizer in the form of unchanged and metabolic forms. After drinking, about 4% of the dose is excreted in the form of constant and about 6% excreted in the form of metabolites that are active in urine. Losartan's final waste time is about 1.5 - 2.5 hours and of E - 3174 is about 3 - 9 hours.

Before taking Lostad T25 25mg Stella treats hypertension (3 blisters x 10 tablets)

How to use

Lostad T25 is used by oral.

Dosage

adults

Hypertension

Normal doses of 50 mg x 1 time/day. If necessary, the dose can be increased by 100 mg once a day or divided into 2 times/day. The maximum hypotension effect is achieved after the beginning of treatment is about 3-6 weeks.

The starting dose of 25 mg x 1 time/day is used for patients to reduce the volume of intravascular fluid. This dose is also suitable for patients with liver or renal failure.

Kidney disease in patients with type 2 diabetes

Where do you start 50 mg x 1 time/day, increase the dose up to 100 mg 1 time/day depending on the response on blood pressure.

Children

From 6 years of age and older with hypertension with the starting dose of 0.7 mg/kg x 1 time/day, up to 50 mg, adjust the dose depending on the degree of response; The dose is higher than 1.4 mg/kg or 100 mg/day has not been studied.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? The most common manifestation of overdose is hypotension and tachycardia; Slow heart rate can also occur due to sympathetic nerve stimulation (vagus nerves).

If symptomic hypotension occurs, supportive treatments should be taken. Can not remove Losartan or metabolites that are active by hemolysis.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Lostad T25, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Cardiovascular system: Hypotension does not reflect heart quickly.

Central nervous system: insomnia, dizziness.

Endocrine - Metabolism: hyperkalemia.

digestive: diarrhea, indigestion.

Hematology: Light hemoglobin and hematocrit.

Neuropathy - Bone: back pain/leg pain, muscle pain.

kidney: lower blood uric acid (when high doses).

Respiratory: cough (less when using ACE inhibitors), nasal congestion, sinusitis.

Uncommon, 1/1000

Cardiovascular: Hypotenary pressure, angina, A - V degree II, brushed chest drum, slow sinus rhythm, tachycardia, facial edema, blush.

Central nerve: anxiety, loss of air conditioning, confusion, depression, nightmares, migraine, sleep disorders, dizziness, fever. Skin: Hair loss, dermatitis, dry skin, minced, erythema, light sensitivity, itching, urticaria, rash.

Endocrine - Metabolism: gout.

digestive: anorexia, constipation, flatulence, vomiting, loss of taste, gastritis. genital - urinary: Help, sexual reduction, urination, night urine. liver: slightly increase the tests of liver function and slightly increase bilirubin.

Neurosurgery: Perception, tremor, arm pain, hips, shoulders and knees, edema, fibrosis, muscle weakness.

Eyes: blurred vision, burning and eye pain, conjunctivitis, vision loss.

ears: tinnitus. kidney: urinary tract infections, slightly increased urea or creatinin. Respiratory: Difficulty breathing, bronchitis, discomfort in the throat, nosebleeds, rhinitis, airborn.

Other effects: sweating.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Lostad T25 drug is contraindicated in the following cases: Patients with hypersensitivity to Losartan Potassium or any ingredient of the drug.

Be cautious when using

Caution to use Losartan in patients with kidney stenosis.

Losartan is excreted in urine and in bile, so the dose should be reduced in patients with renal impairment and should consider when used for patients with liver failure.

Patients with reduced internal fluid volume (for example, high -dose diuretic users) may occur hypotension; Should adjust the situation of reducing the volume of intravascular fluid before taking the drug, or the starting dose is low.

Due to hyperkalemia, monitoring of special serum levels should be monitored in older adults, patients with renal impairment, and should be avoided simultaneously with potassium diuretics.

Lostad T25 contains lactose. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or glucose - galactose.

The ability to drive and operate machinery

There has been no research on reactions on the ability to drive and operate machinery. However, when driving or operating machinery must pay attention to dizziness and drowsiness can sometimes occur during hypertension treatment, especially when starting treatment or when increasing the dose.

Pregnancy

When used in the second and third quarter of pregnancy, drugs that work directly on the Renin - Angiotensin system may cause damage, even death for the developing fetus. Stop using Losartan as soon as possible when detecting pregnancy.

The period of breastfeeding

Due to the harmful effects for breastfeeding babies, we have to decide whether to stop breastfeeding or stopping the drug, considering the importance of the drug for the mother.

Interactive drug

The work of the drug

In studies on drug interaction, there is no significant pharmacokinetic interaction between losartan and hydrochlorothiazide, digoxin, warfarin, cimetidine and phenobarbital.

Rifampin, a drug metabolic drug, reduces the level of losartan and its active metabolites.

fluconazole, a P450 2C9 inhibitor, reduces the concentration of active metabolites and increases Losartan concentration.

Like angiotensin II blockers or its effect if used simultaneously with potassium diuretics (such as spironolacton, triamteren, amilorid), with potassium supplements, or salt substances containing potassium can lead to hyperiemia.

As well as other hypertension drugs, losartan's anti -hypertension effect may be reduced when using indomethacin, an non -steroid anti -inflammatory drug.

The correspondence of the drug

due to the absence of studies on the cavalry of the drug, not mixing this drug with other drugs.

Storage

Store in closed packaging, dry place, avoid light. The temperature does not exceed 30 ° C.

Other drugs

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