Lostad T25 25mg Stella treats hypertension, reduces the risk of stroke (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Losartan

Ingredient

Composition information	Content
Losartan	50mg

Uses

indications

Lostad drugs are indicated in the following cases:

Hypertension, especially in patients with cough when taking enzyme inhibitors angiotensin and reduces the risk of stroke in patients with left ventricular hypertrophy. Urinary).

The drug is also used in case of heart failure and myocardial infarction.

Losartan and main metabolites have the activity of the drug that prevents vascular contraction and aldosteron secretion of Angiotensin II by inhibiting the cohesion between Angiotensin II and AT1 receptors in many tissues (for example, blood vessel muscles, adrenal glands).

Metabolic substances are more active than Losartan from 10-40 times by weight and is an non -competitive, reversible inhibitor of the AT1 receptor.

Both Losartan and the active metabolites of the drug are not inhibited ACE (Kininase H, Angiotensin I into Angiotensin II and Bradykinin decomposition), they also do not bond or prevent other hormone receptors or ion channels that play an important role in regulating the cardiovascular system.

Dynamic pharmacokinetics

Losartan is easily absorbed through the gastrointestinal tract when taken but significantly metabolized through the liver for the first time, leading to the bioavailability of the whole body is only about 33%. The drug is metabolized into metabolites that have the activity of carboxylic acid derivative E - 3174 (exp - 3174), which has a stronger pharmacological activity than Losartan; Some non -active metabolites are also formed.

The metabolism is mainly due to the isoenzyme of Cytochrome P450 is CYP2C9 and CYP3A4. After a dose of oral, the peak concentration of Losartan's plasma is achieved within 1 hour and E -3174 is reached in the range of 3-4 hours.

Both Losartan and E - 3174 are more than 98%of plasma proteins. Losartan is excreted in urine and in the fertilizer in the form of unchanged and metabolites.

After drinking, about 4% of the dose is excreted in the form of constant and about 6% excreted in the form of metabolites that are active in urine. Losartan's final waste time is about 1.5 - 2.5 hours and of E - 3174 is about 3 - 9 hours.

Before taking Lostad T25 25mg Stella treats hypertension, reduces the risk of stroke (3 blisters x 10 tablets)

How to use

Lostad uses oral.

Dosage

Hypertension

Normal doses of 50 mg x 1 time/day. If necessary, there can be a dose of up to 100 mg x 1 time/day or divided into 2 times/day. The maximum hypotension effect is achieved after the beginning of treatment is about 3-6 weeks.

The starting dose of 25 mg x 1 time/day is used for patients to reduce the volume of intravascular fluid. This dose is also suitable for patients with liver or renal failure.

Kidney disease in patients with diabetes 2

The starting dose of 50 mg x 1 time/day, an increase of the dose to 100 mg x 1 time/day depending on the response on blood pressure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? The most common manifestation of overdose is hypotension and tachycardia; Slow heart rate can also occur due to sympathetic nerve stimulation (vagus nerves).

If symptomic hypotension occurs, supportive treatments should be taken. It is not possible to eliminate Losartan or metabolites that are active by hemolysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Lostad, you may experience unwanted effects (ADR).

Most of the undesirable effects are light and lost over time.

Common, 1/100 ≤ ADR

Cardiovascular: Hypotension does not reflect heart quickly. Mechanical.

Cardiovascular: Lower blood pressure, angina, A - V degree II, Brush the chest, slow sinus rhythm, fast heartbeat, face, blush. light, itching, urticaria, rash. Bone muscles: Perception, tremor, arm pain, hips, shoulders and knees, joint edema, muscle pain, muscle weakness. Throat, nosebleeds, rhinitis, airbodery.

Other effects: Sweating.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Lostad drug is contraindicated in the case of patients with hypersensitivity to Losartan Potassium or any ingredient of the drug.

Be cautious when using

Caution to use Losartan in patients with kidney stenosis.

Losartan is excreted in urine and in bile, so the dose should be reduced in patients with renal impairment and should consider when used for patients with liver failure.

Patients with a decrease in internal fluid volume (for example, high -dose dosage users) may occur blood pressure: Should adjust the decrease in the vol Due to hyperkalemia, serum potassium concentration should be monitored, especially in the elderly, patients with renal impairment, and should be avoided simultaneously with potassium diuretics.

Lostad contains lactose excipients. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or glucose - galactose.

The ability to drive and operate machinery

There has been no research on reactions on the ability to drive and operate machinery. However, when driving or operating machinery must pay attention to dizziness and drowsiness can sometimes occur during hypertension treatment, especially when starting treatment or when increasing the dose.

Pregnancy

When used in the second and third quarter of pregnancy, drugs that work directly on the Renin - Angiotensin system may cause damage, even death for the developing fetus. Stop using Losartan as soon as possible when detecting pregnancy.

The period of breastfeeding

Due to the harmful effects for breastfeeding babies, it is necessary to decide whether to stop breastfeeding or stopping the drug, considering the importance of the drug for the mother.

Drug interaction

In studies on drug interaction, there is no significant pharmacokinetic interaction between losartan and hydrochlorothiazid, digoxin, warfarin, cimetidine and phenobarbital.

Rifampin, a drug metabolic drug, reduces the level of losartan and its active metabolites.

fluconazole, a P450 2C9 inhibitor, reduces the concentration of active metabolites and increases the level of Losartan.

Like angiotensin II blockers or its effect if used simultaneously with potassium diuretics (such as spironolactone, triamteren, amilorid) with potassium supplements, or with salt substances containing potassium that can lead to hyperiemia.

As well as other hypertension drugs, losartan's anti -hypertension effect may be reduced when using indomethacin, an non -steroid anti -inflammatory drug.

Storage

Store in closed packaging, dry place, avoid light. The temperature does not exceed 30 ° C.

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