Lostad T50 50mg Stella treats hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Losartan

Ingredient

Composition information	Content
Losartan	50mg

Uses

indications

Lostad T50 is indicated in the following cases:

Treatment hypertension

Especially in patients with cough when taking angiotensin transferring enzyme inhibitors and reducing the risk of stroke in patients with left ventricular hypertrophy.

Kidney disease treatment in patients with diabetes

Creatinine serum in the range of 1.3 - 3.0 mg/dl in patients 60 kg and proteinuria.

Case treatment heart failure and myocardial infarction .

Pharmacology

Losartan and main metabolites have the activity that prevents the effects of vascular shrinkage and aldosteron secretion of angiotensin II by selecting Angiotensin II cohesion into the AT1 receptor in many tissues (for example, blood vessel muscles, adrenal glands).

Metabolic substances are more active than Losartan from 10 to 40 times by weight and is an non -competitive, reversible inhibitor of the ATI receptor.

Both Losartan and active metabolites are not inhibited ACE (Kininase II, Angiotensin I into angiotensin II and bradykinin decomposition), they also do not bond or prevent receptors of other hormones or ion channels that play an important role in regulating cardiovascular system.

Pharmacokinetics

absorption

Losartan is easily absorbed through the digestive tract after drinking.

Metabolism

Losartan is significantly metabolized through the liver, resulting in the bioavailability of the whole body only about 33%. The drug is metabolized into metabolites with active properties of carboxylic acid derivatives, E-3174 (exp-3174), which has a stronger pharmacological activity than Losartan; Some non -active metabolites are also formed.

The metabolism is mainly due to the isoenzyme of Cytochrom P450 is CYP2C9 and CYP3A4. After drinking, Losartan's peak peak concentration is reached within 1 hour and of E -3174 achieved in minerals 3-4 hours.

Distribution

more than 98% of Losartan and E-3174 associated with plasma proteins.

Elimination

Losartan is excreted in urine and in the stool through the bile duct in a constant form and metabolites. After drinking, about 4% of the dose is excreted in the form of constant and about 6% excreted in the form of metabolites that are active in urine. Half of the lifetime of Losartan is about 1.5 - 2.5 hours and of E -3174 about 3 - 9 hours.

Before taking Lostad T50 50mg Stella treats hypertension (3 blisters x 10 tablets)

How to use

Lostad T50 is used by oral.

Dosage

Adults

Normal doses of 50 mg x 1 time/day. If necessary, the dose can be increased by 100 mg once a day or divided into 2 times/day. The maximum hypotension effect is achieved after the beginning of treatment is about 3-6 weeks.

The starting dose of 25 mg x 1 time/day is used for patients to reduce the volume of intravascular fluid. This dose is also suitable for patients with liver or renal failure.

Children

From 6 years of age and older with hypertension with the starting dose of 0.7 mg/kg x 1 time/day, up to 50 mg, adjust the dose depending on the degree of response; The dose is higher than 1.4 mg/kg or 100 mg/day has not been studied.

Kidney disease in patients with type 2 diabetes

The starting dose of 50 mg x 1 time/day, an increase of the dose to 100 mg x 1 time/day depending on the response on blood pressure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? The most common manifestation of overdose is hypotension and tachycardia; Slow heart rate can also occur due to sympathetic nerve stimulation (vagus body).

If symptomic hypotension occurs, supportive treatments should be taken. Can not remove Losartan or metabolites that are active by hemolysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Lostad T50, you may experience unwanted effects (ADR).

Common, ADR> 1/100:

Neurological: dizziness, headache.

Cardiovascular: Hypotension is related to the dose. Hypotension can occur, especially in patients with reduced intravascular volume (for example, high -dose dosage drug users).

Uncommon, 1/1000

No information.

Rare, 1/10000

Body: tired.

Endocrine - Metabolism: renal function, increased liver enzyme index, hyperkalemia.

Neurosurgery: muscle pain, back pain and joint pain, muscle -lying syndrome.

Respiratory: cough (less cough than other angiotensin enamel inhibitors), respiratory disorders.

Hematology: Neutral leukemia.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Lostad T50 drug is contraindicated in cases of patients with hypersensitivity to active ingredients or any excipients of the drug.

Be cautious when using

Caution to use Losartan in patients with kidney stenosis.

Losartan is excreted in urine and in the bile duct, so the dose should be reduced in patients with renal failure and should be considered for patients with liver failure.

Patients with reduced internal fluid volume (for example, high -dose diuretic users) may occur hypotension; Should adjust the situation of reducing the volume of intravascular fluid before taking the drug, or the starting dose is low.

Due to hyperkalemia, monitoring of special serum levels should be monitored in the elderly, patients with renal impairment, and should be avoided simultaneously with potassium diuretics.

Lostad T50 contains lactose. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or poorly absorbed glucose-galactose.

The ability to drive and operate machinery

There has been no research on reactions on the ability to drive and operate machinery. However, when driving or operating machinery must pay attention to dizziness and drowsiness can sometimes occur during hypertension treatment, especially when starting treatment or when increasing the dose.

Pregnancy

When used in the second and third quarter of pregnancy, drugs that have a direct effect on the renin-angiotensin system may cause damage, even death for the developing fetus. Stop using Losartan as soon as possible when detecting pregnancy.

The period of breastfeeding

Due to the harmful effects for breastfeeding babies, it is necessary to decide whether to stop breastfeeding or stopping the drug, depending on the importance of the drug for the mother.

Drug interaction

In studies on drug interaction, there is no significant pharmacokinetic interaction between losartan and hydrochlorothiazide, digoxin, warfarin, cimetidine and phenobarbital.

Rifampin, a drug metabolic drug, reduces the level of losartan and its active metabolites.

fluconazole, a P450 2C9 inhibitor, reduces the concentration of active metabolites and increases the level of Losartan.

Like other Angiotensin II blockers or similar effects, if used simultaneously with potassium diuretics (such as Spironolacton, Triamteren, Amilorid), with potassium supplements, or salt -containing salt substitutes that can lead to hyperiemia.

As well as other hypertension drugs, losartan's anti -hypertension effect may be reduced when using indomethacin, an non -steroid anti -inflammatory drug.

Storage

Store in closed packaging, dry place, avoid light. The temperature does not exceed 30 ° C.

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