Lotemax eye drops 0.5% bausch & loomb treatment for eyelid conjunctivitis, eyeball (5ml)
Dosage form Bottle x 5ml
Specifications Loteprednol Etabonate
Ingredient
| Composition information | Content |
| Loteprednol Etabonate | 0.5% |
Uses
Indications
Lotemax® is indicated in the following cases:
Loteprednol Etabonate has the same structure as other corticosteroids. However, in its structure, the ketone is absent at the No. 20. It is a very oil body, and thereby easily penetrating the cells. Loteprednol Etabonate is synthesized by changing the structure of the compounds similar to Prednisolon so that it can create a compound that specialized products are no longer active. According to studies on clinical and clinical metabolism In Vitro and In Vivo, Loteprednol Etabonate is metabolized almost completely into non -active carboxylic acid metabolites.
Clinical research
Before taking Lotemax eye drops 0.5% bausch & loomb treatment for eyelid conjunctivitis, eyeball (5ml)
How to use
Lotemax drugs use eye small eyes.
Shake vigorously before use.
Dosage
Treatment of disease responds to steroids
Small one to two drops of lotemax® into the conjunctiva bag of the infected eye, 4 times a day. The starting dose in the first week of treatment may increase to one drop per hour if needed. Pay attention continuously treatment too early. If the signs and symptoms do not decrease after 2 days of treatment, the patient needs to be checked again (see the cautious part).
postoperative inflammation
Small 1 to 2 drops of Lotemax® into the conjunctiva bag of the surgical eye 4 times a day, starting 24 hours after the surgery and continues during the first 2 weeks of the postoperative stage.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when overdose?
No information.
What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using Lotemax®, you may experience unwanted effects (ADR).
The reactions related to eye tracid steroids include glaucoma, which can lead to optic nerve damage, vision and vision of the eye, cataracts under the following, secondary eye infections from pathogens such as Herpes Simplex , and holes on the eyeballs due to thin cornea or nervous.
Unwanted effects on the eyes appear at 5-15% of patients using Loteprednol Etabonate eye intervention (0.2% - 0.5%) in clinical trials, including abnormal/blurred vision, hot eyes, conjunctiva, eye -eyed, dry eyes, watery eyes, sensation of exoticity in the eyes, itchy eyes, congestion and fear of light. Other side effects of the eye occur in 5% of patients including unusual conjunctivitis, cornea, eyelid redness, ironic - conjunctivitis, itching/pain/discomfort in the eyes, thorns, uveitis. Part of the aforementioned side effects are similar to the basic eye diseases that have been studied.
Side effects outside the eye appears with 15% of patients, including headaches, rhinitis and sore throat .
Summary of controlled random studies in patients using Loteprednol Etabonate lasting 28 days or longer showing that the proportion of patients with obvious glaucoma (≥ 10 mmHg) is 2% (September 1501) The total number of patients using Loteprednol Etabonate, 7% (11/164) The number of patients using Prednisolin Acetate 1% and 0.5% (3/585) Okay.
Instructions on how to handle ADR
Notify the doctor with unwanted effects when using the drug.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Lotemax® drug contraindicated in the following cases:
Lotemax, like other corticosteroid eye medications, is contraindicated for most cornea and conjunctiva diseases including viral spotted keratitis caused by herpes Simplex (piniccutitis), seasonal bean disease, chickenpox , and eye -infections caused by mycobacteria and eye -catching eye -catching.
Cases of a history or suspicion of hypersensitivity to any component of the drug or other corticosteroids.
Caution when using
Lultered corticosteroid use can cause glaucoma to cost the vision, reduce vision and vision of the eye, and lead to cataracts under the bag. Kidney need when using steroids for patients with glaucoma.
The prolonged corticosteroid use may reduce the body's response ability, thus increasing the risk of secondary eye infections. In patients with thin cornea or fracture, punctured when using local corticosteroids. In the case of acute eye festering, steroids can hide symptoms of infection or worsen infection.Using eye sugar steroids can pull the treatment time and make many cases of eye virus infection (including herpes simplex infection). Must be cautious when treating corticosteroids for patients with a history of herpes Simplex infection.
Using steroids after a hydrological surgery can slow down the incision and increase the ability to form blisters.
Only use eye look. The first medication or repeated use lasts more than 14 days must be due to a doctor's prescription after conducting an examination with exaggerated equipment such as slot lights, and when necessary, using fluorescent dye.
If signs or symptoms do not decrease after 2 days of medication, patients need to be examined again.
If this drug is used for 10 days or longer, the glaucoma must be checked, even on patients who are difficult to perform such as children or patients who are not ready to cooperate.
Cive fungal infections are often detected simultaneously with the long -sized steroid use. Therefore, pay attention to the risk of infection in the case of long -term corneal ulcer or steroids. Take a grip culture test sample if necessary.
Information for patients
Aseptic packaging products. Advise the patient not to let the drip tip touch any surface because it can cause an epidemic contamination. If the eyes are painful, red, itchy or inflammation becomes worse, the patient should consult a doctor. Like other benzalkonium chloride ophthalmic preparations, patients should not wear soft contact lenses during treatment with Lotemax®.
The ability to cause cancer, mutations, reproductive decline
There has been no long -term studies on animals about the cancer ability of Loteprednol Etabonate. Loteprednol Etabonate has no toxicity on the gene when testing printing in vitro by AMES test, testing tk tk mouse lymphatic cell tumor, or testing to falsify chromosomal structures on human lymphatic cells, or when testing in Vivo by testing single -dose micro doses on the mouse. Loteprednol Etabonate treatment on male and female rats with doses of up to 50 mg/kg/day and 25 mg/kg/day (600 times and 300 times the maximum dose on clinical) before and during the mating period does not impair the fertility of both sexes.
The ability to drive and operate machinery
No information.
Pregnancy
Group C. Return to Loteprednol Etabonate Rabbits 3mg/kg/day (35 times the maximum daily dose of clinical) during the formation of fetal organs that do not poison the mother rabbit but show the poisoning effect on the embryo (slow chemistry) and the effect of monitoring (increase the percentage limbs curved). The dose level does not cause observation effects (No - Observed - Effect - Level, Noel) for these effects are 0.5 mg/kg/day (6 times the maximum daily dose of clinically). Giving rats to take medicine during the formation of Bao Thai's organs also leads to teratogenicity (a short arm artery deficiency at the dose> 5 mg/kg/day, cleft palate and umbilical hernia at the dose> 50 mg/kg/day) and embryo toxicity (increasing the fetal rate at the dose of 100 mg/kg/day, fetal weight reduction and hardening of hardening at the dose> 50 mg/kg/day).
Treatment for rats at a dose of 0.5 mg/kg/day (6 times the maximum daily dose of clinical) during the formation of fetal organs does not cause any reproductive toxicity. Loteprednol Etabonate for rats pregnant with a dosage> 5 mg/kg/day during the formation of fetal organs toxic fetuses for the mother (significantly reducing body weight when treated).
Give Cai Cai rats to drink Loteprednol Etabonate at a dose of 50 mg/kg/day from the beginning of pregnancy until the end of the breastfeeding period, which is toxic to the mother (significantly reducing the mother's weight), reducing the survival rate and reducing the physical and brain development in the child's individuals during the breastfeeding period; The dose level does not cause visual images for these effects is 5 mg/kg/day. Loteprednol Etabonate does not affect the period of pregnancy or the birth of pregnant mice when taking the dose up to 50 mg/kg/day during pregnancy.
Breastfeeding period
It is still unclear whether corticosteroids used on the spot through the eye can cause enough body absorption to produce an amount that can be detected in breast milk or not. The systemic steroids appearing in breast milk can prevent the growth, hindering endogenous corticosteroids, or causing other unwanted effects. Be cautious when using Lotemax® for breastfeeding women.
for children
The effectiveness of treatment and safety level when giving children is still not fully studied.
Drug interaction
No information.
Storage
Store vertical posture, temperature not exceeding 30 ° C. Do not freeze.
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