LOXCIP 180mg Aurochem Pharma tablets treat allergic rhinitis (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Fexofenadina
Indication Rhinitis, allergic rhinitis, eczema, psoriasis, atopic dermatitis, stuffy nose

Ingredient

Composition information	Content
Fexofenadina	180mg

Uses

Indications

LOXCIP 180mg drug is indicated for treatment of allergic rhinitis symptoms in adults and children ≥ 12 years old.

The symptoms effectively treated are: sneezing, runny nose, itchy palate and throat, itchy eyes and tears.

Pharmacokology

Fexofenadine is a new generation anti -allergy drug - H1 receptor resistance.

Fexofenadine is a prolonged antihistamine anti -healing drug to treat allergies, no sedative effects.

Fexofenadine, the metabolic substance of terfenadine, is a antihistamine anti -antagonist with selective antagonistic effect in the peripheral receptor.

Fexofenadine inhibits bronchial shrinkage caused by antigen in sensitive mice, and inhibits histamine secretion from the peritoneal moisturizer of the rat.

On experimental animals, no anti -anti -cholinergic effects or A1 receptor inhibitors - adrenergic.

Moreover, there is no sedative effect or other effects on the central nervous system.

Research on rats about the distribution in the tissue of Fexofenadine has marked, showing that this drug does not pass the blood - brain barrier.

pharmacokinetics

In healthy volunteers, after taking the only dose of 2 tablets 60mg, Fexofenadine Hydrochloride is quickly absorbed with an average time to achieve maximum concentration in plasma of 2.6 hours.

In healthy people, after taking the only dose of the solution containing 60mg, the average serum average concentration is 209ng/ml.

When a healthy volunteer uses many consecutive doses of fexofenadine hydrochloride (60ml oral solution, every 12 hours, and taking 10 doses like that), the peak concentration of the drug is 286ng/ml.

Take the dose of 120mg at a time, use 2 times daily, Fexofenadine Hydrochloride will have linear pharmacokinetics.

Effects of age

In the elderly (≥ 65 years), the peak concentration of Fexofenadine hydrochloride in plasma is higher than 99% of this concentration of this drug in normal volunteers (

Renal failure

In people with mild kidney failure (creatinine clearance 41 - 80ml/min) to severe (creatinin clearance 11 - 40ml/min) the peak concentration of fexofenadine hydrochloride in larger plasma (87% and 111%) compared to healthy volunteers; The average half -life in the above kidney failures is also longer (59% and 72%) than healthy people.

The peak concentration of Fexofenadine hydrochloride in the plasma plasma (creatinine clearance

Based on the increase in biodiversity and the half -life, the only dose should be used for 60mg/24 hours at the beginning of the drug in people with kidney failure.

People with liver failure

The pharmacokinetics of Fexofenadine Hydrochloride in people with liver failure are not much different from in healthy people.

The influence of gender

Through many tests, there is no difference between the male and female pharmacokinetics of Fexofenadine Hydrochloride.

Before taking LOXCIP 180mg Aurochem Pharma tablets treat allergic rhinitis (10 blisters x 10 tablets)

How to use

LOXCIP 180mg medicine is used by oral.

Take the tablet with a glass of water.

Dosage

Adults and children ≥ 12 years: recommendations 60mg x 2 times/day or 180mg x 1 time/day.

The starting dose for kidney failure is a single dose of 60mg/24 hours.

The elderly and patients with liver failure do not need to reduce the dose.

Should use Fexofenadine 2 hours away from antacids containing aluminum or magnesium gel.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Loxcip 180mg, you may experience unwanted effects (ADR).

Side effects may occur: headache, dizziness, diarrhea, vomiting, arm pain, legs or back, pain during menstruation, cough, urticaria, rash, itching, difficulty breathing or difficulty swallowing, swelling of the face, throat, tongue, lips, eyes, legs, leg ankles, legs or lower legs, hoarseness, difficulty swallowing or shortness of breath. Fexofenadine can cause other side effects.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the Loxcip 180mg, you need to read the instructions carefully and refer to the information below.

Contraindicated

LOXCIP 180mg contraindications in the following cases:

Normally people who are allergic to any substance in the ingredients of the drug are not allowed to take the drug.

Other cases are specified in the instructions for drug use or prescription doctor.

Loxcip contraindications must be understood as absolute contraindications, which is not for some reason that the case of flexible contraindications can be used.

Be cautious when using

Before using Fexofenadine, let the doctor and pharmacist know if you are allergic to Fexofenadine, any drug or any ingredient of Fexofenadine and the drugs you are taking or intended to use. Tell your doctor if you have or have kidney disease.

Children: The safety and effectiveness of Fexofenadine has not been set in children under 6 months of age.

Elderly: Fexofenadine is significantly excreted through the kidneys. Elderly people are more likely to suffer from renal failure, need to be cautious in choosing the dose and should monitor the kidney function.

renal failure: Dosage reduction in patients with renal failure.

Pregnancy and nursing mothers

Pregnant women

There is no adequate and well -controlled research in pregnant women. Only use LOXCIP 180 drug during pregnancy when the maternal benefit is better than the potential risks for the fetus.

breastfeeding mothers

Do not know if Fexofenadine is excreted in breast milk or not. Because there are many drugs excreted in breast milk, be careful when using Fexofenadine for breastfeeding people.

Medicinal interaction

Medications may occur with LOXCIP 180mg:

Antacids containing aluminum or magnesium gel reduces the bioavailability of fexofenadine. These drugs should be used 2 hours apart.

Use combination of fexofenadine with erythromycin or ketoconazole increase fexofenadine levels in plasma 2-3 times. However, this increase does not lead to influence on the QT interval, and compared to the above drugs when used individually does not see any additional side effects.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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