Loxfen 60mg Shinpoong Deawoo anti -inflammatory pain relief (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Loxoprofen

Ingredient

Composition information	Content
Loxoprofen	60mg

Uses

Indications

LoxFeb is indicated in the following cases:

Analgesic and anti -inflammatory in the following symptoms: Chronic rheumatoid arthritis, osteoarthritis, back pain, shoulder arthritis, hand syndrome.

Relieve mild to medium and anti -inflammatory pain after surgery, trauma or after tooth extraction. The drug can also be used to reduce muscle pain, nerve pain, migraine, headache, toothache, dysmenorrhea.

Antipator of fever and anti -inflammatory in the upper respiratory tract infection (attached or not accompanied by bronchitis).

Pharmacy

Loxoprofen sodium is a nonsteroidal anti -inflammatory drug of the group of phenylpropionic acid with strong peripheral analgesic, antipyretic and anti -inflammatory. The main advantage of sodium Loxoprofen compared to other NSAIDs is because the drug is in the form of precursor, causing less gastrointestinal ulcers. Analgesic, anti -inflammatory and antipyretic properties are 10-20 times stronger than other NSAIDs such as Ketoprofen, Naproxen and Indomethacin.

Anti -inflammatory mechanism is to reduce prostaglandin biosynthesis by inhibiting cyclooxygenase.

After drinking, sodium Loxoprofen is absorbed intact through the digestive tract and quickly converted into active substances, derivative - OH "Trans", has the effect of inhibiting Prostaglandin biosynthesis.

pharmacokinetic

After drinking, Loxoprofen is quickly absorbed from the gastrointestinal tract in the form of constant, less irritating the gastric mucosa, and then quickly converted into active metabolites, derivative - OH.

The peak concentration of Loxoprofen plasma (constant form) and metabolites achieved are after 30 and 50 minutes after drinking. The half -life of both is about 1.25 hours.

In a study of metabolic inhibition with Invitro liver microsome, sodium Loxoprofen does not affect the metabolism of many metabolic drugs by Cytochrome P450, even at a concentration of 10 times larger than the peak concentration in plasma (200 mm).

Plasma protein mounting ratio is about 97.0% for loxoprofen and 92.8% for Trans - OH derivative. The AUC of Loxoprofen is 6.70 + 0.26 mg.h/ml and the trans - OH compound is 2.02 + 0.05 mg/ml.

Loxoprofen is quickly excreted through urine. About 50% of the dose is eliminated after 8 hours, in the form of Loxoprofen, Glucuronate and Trans - OH.

Before taking Loxfen 60mg Shinpoong Deawoo anti -inflammatory pain relief (10 blisters x 10 tablets)

How to use

Loxfen drugs are used for oral. Drink during or after meals.

Dosage

Normally, the recommended dose in adults is 60 mg x 3 times/day.

In the case of acute, the single dose can be taken only 60 - 120 mg.

Should adjust the dose depending on age and symptoms, should not exceed the dose of 180 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

There has been no report on the overdose of Loxoprofen. However, if overdose occurs, signs and symptoms will be similar to harmful reactions, but more severe.

Handling

There is no specific antidote to the sodium Loxoprofen. You can drink activated carbon or gastric lavage that patients overdose the drug; Within 1 hour. Watch the patient closely. The main treatment is symptomatic and supportive treatment. Maintain fluid balance, ventilation. And track cardiovascular signs and survival signs until stable.

Can take anti -convulsions if indicated. Use bronchodilators if asthma occurs.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Loxfen, you may experience unwanted effects (ADR).

Common

rash; asleep; edema; Abdominal pain, stomach discomfort, anorexia, nausea and vomiting, diarrhea; Liver enzyme increase.

rarely

Stomach ulcer - duodenum, constipation, heartburn, stomatitis.

rarely

urticaria; indigestion; headache; Anemia, leukopenia, eosinophilia, alkaline phosphatase, nervous and hot.

Instructions on how to handle ADR

Notice the doctor the side effects encountered when taking the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Loxfen drugs contraindicated in the following cases:

Too hypersensitivity to Loxoprofen or any ingredients of the drug.

History of hypersensitivity reactions (such as asthma, rhinitis, angioedema or urticaria) when taking aspirin or other nonsteroidal anti -inflammatory drugs (NSAID).

Progressive stomach ulcer.

Severe heart failure; Severe disorders on hematology, on the liver or on the kidneys.

Pregnant women.

Precautions when using

Use cautiously in the following patients:

Having a history of stomach ulcer, bleeding or perforation of the above digestive tract, especially when related to NSAID drugs.

Crohn's disease.

Hypertension (blood pressure may change during treatment with NSAIDs) or other cardiovascular disorders.

infection: Symptoms such as fever and inflammation may be hidden when using NSAIDs. Therefore, it is advisable to coordinate with appropriate antibiotics when infected by infection. In this case, medication should be used and observed patients carefully.

Asthma or other allergic disorders.

Bleeding disorders, impaired liver or kidney function.

Patients with long -term loxoprofen should monitor the appearance of blood, liver or kidney disorders. If there is a change, the dose should be reduced or stopped.

For the treatment of acute diseases, it is advisable to consider the severity of inflammation, pain or fever; Priority is given to the treatment of specific causes of the disease.

Harmful reactions often occur in older adults, especially on the digestive tract. Use caution in the elderly and may need to reduce the dose. Should start treatment at the lowest dose.

The safety of drugs in children under 18 years of age has not been studied.

The ability to drive and operate machinery

Side effects such as dizziness, drowsiness, fatigue, visual disorders can occur when taking the drug.

Pregnancy

has not determined the safety of the drug during pregnancy. Do not take medication during pregnancy or during labor unless the benefits of the drug for the mother are greater than the potential risk to the fetus.

Breastfeeding period

Should avoid using Loxoprofen (if possible) when breastfeeding.

Drug interaction

Do not coordinate loxoprofen with aspirin (except for low -dose aspirin, no more than 75 mg/day, and must be prescribed by a doctor) or with other NSAIDs: because it can increase the risk of side effects.

Should be cautious when coordinating Loxoprofen with the following drugs:

Corticosteroids: may increase the risk of side effects, especially on the digestive tract.

Hypertension and diuretics: NSAIDs can reduce the effects of these drugs.

Anticoagulants: NSAID can increase the effects of anticoagulants like warfarin.

Anti -platelet aggregation drugs and selective Serotonin reabsorption drugs (SSRI): Increases the risk of gastrointestinal bleeding.

Cardia glycosides: NSAID worsen heart failure, reduce glomerular filtration (GFR) and increase plasma glycosides. lithium: may increase plasma lithium concentration.

Methotrexate: may increase plasma methotrexate levels.

ciclosporin, tacrolimus: Increased risk of toxicity on the kidneys.

Mifepriston: Do not use NSAID within 8 - 12 days after taking Mifepriston because NSAID can reduce the effect of Mifepriston.

Zidovudin: Increasing the risk of joints and hematoma in hemorrhage in people with HIV infection.

Quinolon antibiotics: Increased risk of convulsions.

Storage

In closed packaging, in a dry place, avoiding the light of temperature below 300C.

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