Lyrica 150mg viatris treatment of neurological pain, epilepsy, anxiety disorders (4 blisters x 14 tablets)

Dosage form Box of 4 blisters x 14 tablets
Specifications Pregabalin

Ingredient

Composition information	Content
Pregabalin	150mg

Uses

indicated

Pregabalin is indicated in the following cases:

Neurological pain treatment in adults

Epilepsy treatment

Pregabalin is indicated for treatment of local epilepsy support, with or not accompanied by secondary alignment in adults.

Pharmacokic

Pregabalin is a substance similar to gamma-aminobutyric acid (GABA) (acid (s) -3- (aminomethyl) -5-methylhexanoic). Pregabalin is attached to a sub-unit (α2- ᵟ protein) of the calcium voltage channel in the central nervous system. Evidence from nerve -damaged animal models shows that pregabalin reduces the release of neurotransmitter perceive pain depends on the spinal cord, maybe by preventing calcium trips and reducing calcium. Evidence from other animal models that have nerve damage also shows that pregabalin analgesic activity can be indirectly interacted with nervous lines transmitted by Noradrenalin and Serotonin.

Pharmacokinetics

absorption

Pregabalin is quickly absorbed when drinking hungry, the peak concentration in plasma is achieved after 1 hour in both single and multi -dose mode. The oral bioavailability of Pregabalin is about> 90% and does not depend on the dose. When used repeated, the stability is achieved within 24 to 48 hours. Pregabalin's absorption rate decreased when used in the same food, resulting in CMAX decreased by about 25-30% and TMAX was about 2.5 hours behind. However, using pregabalin along with food does not have any significant clinical effects to the level of pregabalin absorption.

Distribution

Pregabalin's apparent distribution volume after oral use is about 0.56 l/kg. Pregabalin is not attached to plasma proteins.

Metabolism

Pregabalin is negligible in the human body. After using Pregabalin with radioactive markers, about 98% of radioactive activity found in pepper water is of pregabalin in the form of unprover. Pregabalin's N-methyl derivative, which is the main metabolic substance of pregabalin found in urine, accounting for about 0.9% of the dose.

Elimination

Pregabalin is eliminated from the circulatory system mainly due to the excretion through the kidneys in the form of non -chemicals. The average selling time of pregabalin is 6.3 hours.

Before taking Lyrica 150mg viatris treatment of neurological pain, epilepsy, anxiety disorders (4 blisters x 14 tablets)

How to use

Pregabalin can drink with food or not.

Dosage

Adults

The dose range from 150 mg to 600 mg daily is divided into 2-3 times.

Neurological pain: Pregabalin treatment may start at a dose of 150 mg daily. Depending on the response and tolerance of each patient, the dose may increase to 300 mg/day after a period of 3-7 days, and if necessary, it may increase to a maximum dose of 600 mg/day after about 7 days of additional treatment.

Pain of muscle fibrosis: The usual dosage for most patients is from 300 mg to 450 mg/day is divided into 2 times. Some patients may achieve better treatment effect at a dose of 600 mg/day. It should be started at a dose of 75 mg, 2 times/day (ie 150 mg/day) and can increase to 150 mg, 2 times/day (ie 300 mg/day) within 1 week depending on the efficiency and tolerance.

Patients who do not have a full response to a dose of 300 mg/day may increase to a dose of 225 mg, 2 times/day (ie 450 mg/day). If necessary, in some patients, depending on the response and tolerance of each patient, it may increase to the maximum dose of 600 mg/day after 1 week of additional treatment.

Epilepsy: may start treatment with pregabalin at a dose of 150mg per day. Depending on the response and tolerance of each patient, the dose may increase to 300 mg/day after 1 week. It may increase to a maximum dose of 600 mg/day after 1 week of additional treatment.

Dissemination anxiety disorders: The dose range from 150 mg - 600 mg daily is divided into two or three times. It is necessary to regularly re -evaluate the treatment needs. Pregabalin treatment may be started at a dose of 150 mg/day. Based on the response and tolerance of each patient, the dose can be increased to 300 mg/day after 1 week of treatment. After an additional 1 week of treatment, the dose may increase to 450 mg/day. Can increase to a maximum dose of 600 mg/ day after 1 week of additional treatment.

If you have to stop using pregabalin, it is necessary to reduce the dose slowly for a minimum of 1 week.

Children

Not yet determined safety and effectiveness in children under 12 years old and adolescents (12-17 years old).

Older people (over 65 years old)

Elderly patients may need to reduce pregabalin dose due to renal function.

Patients with renal failure

Dosage reduction in patients with impaired renal function depending on the clearance of creatinine (CLCR), as shown in Table 1 and is determined by the following formula:

Cl cr (ml / minute) = (x x 0.85 for female patients)

Pregabalin is effectively removed from plasma by hemorrhage (50% of the drug in 4 hours). For patients who are getting hemorrhage, pregabalin's daily dose should be adjusted based on kidney function. In addition to daily dose, an additional dose should be used immediately after dialysis treatment every 4 hours (see Table 1).

Table 1. Adjust the pregabalin dose based on kidney function

Creatinine clearance (CLCR)

(ml/minute)

Total daily Pregabalin dose *

Dosage mode

(mg / day)

Maximum dose

(mg / day)

25 - 50 150

Once daily or BID 25 100 Unique dose +

bid = twice broken down

* Total daily dose (mg / day) should be divided as directed by the dose mode to provide mg / dose

Additional dose is a single additional dose

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using lyrica 150mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Systemic: Peripheral edema, edema, abnormal gait, falling, feeling of drunkenness, fatigue, weight increase.

Respiratory: Rhinitis throat. Neurological: Dizziness, drowsiness, headache , dizziness, mood of excitement, confusion, irritability, disorientation, insomnia, desire, forgetting, memory impairment, attention disorders, chaos, sedation, balance disorders, coma.

Eyes: blurred vision, double look.

digestive: vomiting, nausea, constipation, diarrhea , flatulence, bloating, dry mouth. heart: arrhythmia
Muscle and connective tissue: muscle cramps, joint pain, back pain, limb pain, cervical spasm.
Reproduction: erectile dysfunction .
Uncommon, 1/1000
Systemic body: Systemic edema, face, chest, pain, fever, thirst, chills, weakness.
heart: tachycardia, atrial atrial block one, Sinus heart rate Sinus, congestive heart failure. blood vessels: hypotension, hypertension, heating, redness.
Respiratory, chest and mediastinum: shortness of breath, nosebleeds, cough, stuffy nose, rhinitis, snoring, dry nose.
digestive: gastroesophageal reflux disease, increased salivation, reducing mouth sensation.
Skin and subcutaneous tissue: Rash, urticaria, itching.
muscle and connective tissue: joint swelling, muscle pain, muscle convulsions, neck pain, muscle stiffness.
Kidney and urinary tract: Urine without control, difficulty urinating.

Reproduction: Sexual dysfunction, slow ejaculation, dysmenorrhea, breast pain.
Biochemical index: Creatine phosphokinase in the blood increases, increased blood glucose, platelets decreases, increased blood creatinine, reduced potassium.

Instructions on how to handle ADR
When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

sensitive to any ingredients of the drug

Be cautious when used

Patients with rare genetic diseases about galactose tolerance disorders, deficiency of lapp lactase or glucose-galactose should not be used.

Some diabetics patients with weight gain when using pregabalin may need to adjust the use of hypoglycemic drugs.

Need to stop using pregabalin immediately if there is angioedema, such as face edema, edema around the mouth, or upper respiratory edema.

Pregabalin treatment often occurs dizziness and drowsiness, which may increase the risk of occurrence in injuries (falling) in the elderly. There have been reports after circulating drugs to lose consciousness, confusion and mental decline.

There have been reports on temporary blurring and some other vision changes in patients using Pregabalin. When stopped taking the drug, these vision symptoms will end or reduce.

There is no adequate data on the use of pregabalin combining with other anti -epileptic drugs to switch to single therapy with pregabalin, after controlling seizures with combined treatment.

In short and long -term treatment with pregabalin, after stopping the drug, observing the cessation syndrome on some patients. The effects mentioned include: insomnia, headache, nausea, anxiety, sweating and diarrhea.

As well as any drugs on the central nervous system (CNS), it is necessary to carefully assess the patient about the history of drug abuse and observe the signs of wrong use or abuse Pregabalin in the patient.

There has been improved kidney function reports after stopping or reducing prefabalin dose.

Because data on patients with severe congestive heart failure is limited, caution should be prudent when taking pregabalin in these patients.

The ability to drive and operate machinery

Pregabalin can cause dizziness or drowsiness and thus can affect the ability to drive or operate machinery. Patients are advised not to drive, operate complicated machines or participate in other adventure activities until it is known whether the drug affects the ability to perform these activities.

Pregnancy

should not use pregabalin during pregnancy unless the maternal benefits are superior to the risk of the fetus. Effective contraception must be used for women of reproductive age when using pregabalin

breastfeeding period

Pregabalin is excreted in milk in breastfeeding women. Due to the safety of pregabalin in newborns, it is not known to be breastfeeding while being treated with pregabalin. When deciding to stop breastfeeding or stop treatment with pregabalin, it is recommended to consider the benefits of breastfeeding for children and the benefits of the mother's treatment.

Drug interaction

Pregabalin can affect the effects of ethanol and lorazepam .

Pregabalin seems to increase cognitive disorders and overall movement functions caused by Oxycodon.

There have been reports on respiratory failure and coma in patients using pregabalin and other central neurological inhibitors.

There have been reports after circulation of events related to lower gastrointestinal function reduction (for example, intestinal obstruction, obstruction, constipation) when taking pregabalin with drugs that can cause constipation, such as Opioid group analgesic.

Storage

Store at temperatures below 30 ° C. Avoid light and moist.

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