Macibin soft capsules 300mg Phil Inter Pharma dissolve gallstones, treat cirrhosis (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Ursodeoxycholic acid

Ingredient

Composition information	Content
Ursodeoxycholic acid	300mg

Uses

indications

Macibin 300 mg is indicated in the following cases:

Melt cholesterol -rich gallstones.

Treatment of primary biliary cirrhosis.

Backup gallstones in fast weight loss people. Ursodeoxycholic acid inhibits synthetic liver and excreted cholesterol, while inhibiting the absorption of cholesterol in the intestine.

Dynamic pharmacokinetics

Ursodeoxycholic acid is absorbed from the digestive tract and undergoing the liver -intestinal cycle. A part of the drug is combined in the liver before being secreted into bile. Thanks to the effect of bacteria in the intestine, the form of free and combined form undergo 7A - dehydroxylation turned into lithocholic acid, a part of the drug is directly eliminated through feces. The rest is absorbed, mostly conjugated and sulphate in the liver before eliminating the feces.

Before taking Macibin soft capsules 300mg Phil Inter Pharma dissolve gallstones, treat cirrhosis (6 blisters x 10 tablets)

How to use

oral medication.

Dosage

melting cholesterol -rich gallstones

Adults: Take 6 - 12 mg/kg/day, take 1 single dose in the evening before going to bed or divided into 2-3 times, so continue taking medicine for 3-4 months after melting stones. The dose may be divided unevenly, the larger dose taken in the evening before going to bed to fight the high level of cholesterol in the early morning. Maximum dose: 15 mg/kg/day.

primary biliary cirrhosis

Adults: Take 10 - 15 mg/kg/day, divided into 2-4 times.

Backup gallstones in people who lose weight fast

Adults: 300 mg/time, 2 times a day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Overall, unusual overdose symptoms do not occur because the absorption of ursodeoxycholic acid decreases when increasing the dose and therefore the drug is more eliminated by feces. No need to apply specific overdose treatment. Diarrhea due to overdose is treated by symptomatic treatment for the purpose of fluid and electrolyte balance.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Macibin 300 mg , you may experience unwanted effects (ADR).

Ursodeoxycholic acid is often well tolerated but may experience some side effects as follows:

Gastrointestinal disorders : There may be nausea, vomiting, diarrhea. Rarely abdominal pain, constipation, heartburn and discomfort in the abdomen.

skin: urticaria, itching rarely occurs.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Macibin 300 mg Contraindications in the following cases:

People have a complete gallbladder.

Patients with severe hepatitis .

Pregnant or lactating women, or women may be pregnant.

People sensitive to bile acid or any ingredient of the drug.

Caution when using

should be cautious when using drugs in people with severe pancreatic disease, people with stomach ulcers, people with stones in gallbladder organs.

The ability to drive and operate machinery

There is no evidence that the drug affects the ability to drive and operate machinery.

Pregnancy

There is no safe data on the use of drugs for pregnant women, especially in the first 3 months of pregnancy. Animal tests show that ursodeoxycholic acid causes teratogenicity when used in the early stages of pregnancy. Do not use this medication for pregnant women.

breastfeeding period

It is unknown whether ursodeoxycholic acid is secreted into breast milk or not. Therefore, do not use this medication for breastfeeding women. If needed to be treated with ursodeoxycholic acid, breastfeeding.

Drug interaction

should not take ursodeoxycholic acid at the same time as activated carbon, Colestyramine, Colestipol or Antacids containing Aluminum Hydroxide and/or Smectite (Aluminium Oxide), because these substances are associated with Ursodexolic acid in the intestine, thus reduces the absorption and effectiveness of drugs of drugs. If it is necessary to use the drugs containing the above substances, take at least 2 hours before or after taking ursodexolic acid.

Ursodeoxycholic acid may increase the absorption of ciclosporin in the intestine. In patients who are treating ciclosporin, the concentration of ciclosporin should be monitored, adjusting the dose if necessary.

Oral contraceptives, oestrogen hormones and medications that reduce blood cholesterol such as clofibrate may increase gallstones, antagonistic with ursodeoxycholic acid, use gallstones to dissolve gallstones.

Storage

Store in closed boxes, avoid light, at temperatures below 30 ° C.

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