Majegra-100 Synmedic tablets treated the function of erection in men (1 blister x 4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications Sildenafil

Ingredient

Composition information	Content
Sildenafil	100mg

Uses

Indications

Majegra - 100 is indicated in the following cases:

Treatment of erection function in men.

Medicines used to treat erection function.

Sildenafil is a selective inhibitor for the ring monophosphate (CGMP) - a special type of phosphodiesterase type 5 (PDE5).

When sexual stimulation, oxid nitric oxidation is released on the spot, Sildenafil's PDE5 inhibitor has increased the concentration of CGMP in the cave, leading to smooth muscle relaxation and blood circulation in the penis organization, thus creating erection.

Sildenafil has no effect when there is no sexual stimulation or no rehabilitation.

pharmacokinetics

Sildenafil Citrate is quickly absorbed after oral, maximum concentration in plasma after taking 100mg tablets reaches about 375.96 + 1.40ng/ml.

The maximum concentration time is about 0.79 + 0.03 hours. 100%bioavailability, plasma sale time is 4.73 hours.

The drug is strongly metabolized by microsom isoenzymes in the liver into an active metabolic substance, which is valid for PDE5 equal to 50% of the original drug.

Sildenafil and the main metabolites are all associated with plasma proteins approximately 96%.

Sildenafil is output in the form of metabolites mostly through feces (about 80% of the dose) and a smaller amount through the urine (approximately 13% of the dose).

Before taking Majegra-100 Synmedic tablets treated the function of erection in men (1 blister x 4 tablets)

How to use

Take oral use. Drink before sexual activity 1 hour.

Dosage

The dose is commonly used for most patients is 50mg, taking 1 hour before sexual activity, although the drug works from 30 minutes to 4 hours after drinking.

The maximum suggestion is 100mg.

In cases such as the risk of increased sildenafil concentration in plasma such as: people over 65 years old, people with liver failure, severe kidney failure, those who are taking cytochrom P450 3A4 inhibitors (such as: erythromycin, ketoconazol, iTraconazole): starting dose is 25mg.

Do not use more than once a day.

What to do when overdose?

The kidneys do not have the effect of Sildenafil from the body because the drug is highly connected to plasma proteins and is not excreted through the urine.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

Side effects are determined including headache, blushing, esophageal obstruction and stuffy nose. Particularly, some patients have visual disorders such as blurred vision, light sensitivity, temporary discrimination between green and blue.

Most of these side effects are usually mild and self -recovered.

There have been reports, although rarely, in some patients with painful erections lasting over 6 hours after using Majegra. If the erection lasts more than 4 hours, you must immediately notify the doctor.

In case of chest pain during or after sexual activity, do not use nitrate but other supportive measures.

Warnings

Contraindicated

Majegra - 100 is contraindicated in the case: Patients with severe heart disease, or have had heart attack, stroke, low blood pressure or uncontrolled high blood pressure.

Patients with severe liver disease, genetic retinal disorders, pregnant and lactating women.

Sildenafil sensitive people or any ingredients of the drug.

Not simultaneously used Majegra with nitrate because Sildenafil increases the hypotension of nitrates, which can cause significant hypotension.

Do not use a combination of Majegra with any other types of reinforcement treatment.

Do not use for people with cardiovascular disease. Do not use for women and children under 18 years old.

Precautions when taking drugs

Patients with anemia (with abnormal erythrocytes), people with canal tumors (bone marrow cancer), leukemia (cancer related to leukemia) or any deformation in the penis.

Patients with severe kidney or liver disease.

Sildenafil's safety in patients with blood disorders and patients with intestinal ulcers have not been determined, so they must be cautious when used for these patients.

People with myocardial infarction, stroke or arrhythmia threaten life in the past 6 months. Patients with hypotension (BP 170/110).

Patients with heart failure or coronary artery disease cause unstable angina. Patients with pigmentitis. This drug is indicated for each person, not given to others even though their symptoms are like yours.

The ability to drive and operate machinery

Dizziness, headache, blurred vision, visual disorders are side effects recorded in clinical tests in men using Majegra, so patients need to assess their response before driving or operating machinery.

Pregnancy and lactation

contraindicated.

Other special subjects (elderly, children, allergies)

Do not use for children under 18 years old.

Drug interaction

Sildenafil is metabolized in the liver mainly thanks to CYP3A4. CYP3A4 inhibitors such as: cimetidin, erythromycin, ketoconazole and iTraconazole may increase Sildenafil's concentration when used simultaneously.

Use combined Sildenafil with amlodipine for patients with hypertension may increase the effect of lowering blood pressure.

The area under the concentration curve - The time of metabolites has the activity N - Demethyl Sildenafil is increased by 102% by the Non -specific beta blocker and an increase of 62% by diuretics or potassium diuretics.

Single dose of antacids (Magnesi hydroxid, aluminum hydroxid) does not affect the bioavailability of Sildenafil.

SILVER SILLENAFIL UNIVERSITY, along with liver enzyme induction drugs increase Sildenafil's clearance, reduces the concentration of C and Sildenafil (for example, Rifampicin).

A -blocker: When using simultaneously PDF Typ 5 inhibitors (such as Sildenafil, Tadalafil, Vardenafil) with A - Blocker substances that may have increased hypotension.

Patients who are being treated with D - Blocker substances (Terazosin, dosazoxin, tamlulosin) when combining Sildenafil must be used with a minimum dosage, whereas patients are taking Sildenafil when they need to combine with substances A - Blocker also have to use the minimum doses of substance A - Blocker.

Hydropower: Sildenafil has a vasodilation effect and may increase the hypotension of anti -hypertension drugs. Sildenafil when using nitrate or nitrite simultaneously can cause hypotension. Hypoglycemia that threatens life or damage to hemodynamics may occur.

The previous studies have not seen increased hemorrhagic effects of Sildenafil when used for patients being treated with anti -hypertension drugs, but in some patients (especially those who are suffering from cardiovascular disease, or are active in sexual), hypotension caused by Sidelnafil should be concerned.

In patients being treated with anti -hypertension drugs (Adrenergic inhibitors, thiazids, diuretics or potassium -keeping, calcium inhibitors, angiotensin transferring enzymes inhibitors ) when simultaneously used with Sildenafil does not see the phenomenon of increased hematoma, but there are some patients using hypertension drug diuretics or potassium holders, non -specific Adrenergic inhibitors, amlodipine, α - adrenergic inhibitors.

Hypotension can increase in patients using Sildenfil with many drugs, including anti -hypertension drugs and inhibit the CYP3A4 enzyme system. Therefore, it is necessary to be cautious when using Sildenafil for people who are suffering from congested heart failure, those who have a volume of circulating/low blood pressure below the limit, those who obstruct the left ventricular flow, those who damage the automatic blood pressure regulating the blood pressure.

HIV Protense inhibitors:

In normal combination treatment, including one or more HIV protease inhibitors, CYP3A4 or CYP2C9 inhibitors are likely to affect the Sildenafil clearance (reducing Sildenafil's clearance), which increases the desired effects of Sildenafil such as headache, blushing, visual changes, diamonds, blood pressure and fainting can occur.

Be cautious when taking Sildenafil for patients who are taking HIV Protease or Delavirdin inhibitors because they may increase the risk of undesirable effects of Sildenafil, and must immediately notify the doctor when there are abnormal symptoms that occur. Do not use Sildenafil simultaneously with HIV protease inhibitors for patients with hypertension pulmonary pressure.

Bosentan: Bosentan is a moderate touch substance with CYP3A4, CYP2C9, (and capable of CYP2C19), which can increase Sildenafil clearance and reduce Sildenafil levels. CYP3A4, when used simultaneously with Sildenafil can change the plasma concentration of Sildenafil or CYP3A4 induction substances, and need dose adjustment. Or of CYP3A4 touch substances. Heparin has seen affecting bleeding time. However, there is no human research document. Therefore the toxic effects for the heart, hypotension, bleeding when using Tsildenafil and Phosphodiesterase inhibitors are not known.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer.

You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist.

Keep pills out of reach of children and pets.

Expiry date: 36 months from the date of manufacture.

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