Marvelon Bayer is used for contraception (1 blister x 21 tablets)

Dosage form Tablet
Specifications Box of 1 blister x 21 tablets
Ingredient Desogestrel, ethinyletradiol

Ingredient

Thành phần cho 1 viên

Composition informationContent
Desogestrel0.15mg
Ethinylestradiol0.03mg

Uses

Indications

Marvelon drugs are indicated for contraception.

Pharmacokological

contraceptive effects of contraceptives combined based on the interaction of many different factors, most importantly, the inhibition of ovulation and changes in cervical secretions. As well as protecting contraceptive, combined contraceptives have a number of positive properties, besides negative properties, can be helpful in deciding the contraceptive method.

With oral contraceptives in combination with high doses (50mcg ethinylelestradiol), evidence of reducing the risk of breast fibers, ovarian cysts, pelvic infections, uterine fetuses and endometrial cancer and ovarian. For low -dose contraceptives, the above effects still need to be confirmed.

Pharmacokinetic

Desogestrel

absorption

Desogestrel is absorbed quickly and completely and is transformed into Etonogestrel. The peak concentration of plasma is about 1.5 hours. Birth is 62 - 81%.

Distribution

Etonogestrel is attached to plasma albumin and with global hormone globulin (SHBG). Only 2 - 4% of the total drug concentration in plasma are present in the form of free steroids, 40-70% specific to SHBG. The increase in SHBG caused by EthinyleLestradiol affecting the distribution on plasma proteins, increasing the composition associated with SHBG and reducing the composition associated with albumin. Desogestrel's apparent distribution volume is 1.5L/kg.

Metabolism

Etonogestrel is completely metabolized by known steroid metabolism. The speed of metabolic discharge from plasma is about 2ml/minute/kg. No interaction when used with ethinylestradiol.

Elimination

Etonogestrel concentration in plasma decreases into two phases. The last phase has a selling time of about 30 hours. Desogestrel and its metabolites are excreted in urine and in bile in a ratio of about 6: 4.

ethinylestradiol

absorption

Ethinylestradiol is absorbed and completely absorbed. Peak concentration in plasma is achieved within 1-2 hours. Absolute bioavailability is about 60%, which is a consequence of the combination before entering the blood and the first metabolism in the liver.

Distribution

Ethinylestradiol is mounted but not specific to plasma albumin (about 98.5%) and increases SHBG levels in plasma. The apparent distribution volume is determined at about 5L/kg.

Metabolism

Ethinyylestradiol is a substance that is conjugated in the small intestinal mucosa and in the liver before entering the blood. Ethinylestradiol is mainly metabolized by aromatic hydroxylation but forms a series of hydroxyl and methylation metabolites and these substances are present in the form of free metabolites and associated substances with glucuronide and sulfate. Metabolic clearance speed is about 5ml/minute/kg.

Elimination

Ethinylelestradiol concentration in plasma decreases into two phases. The last phase has a sale time of about 24 hours. The drug is not altered, the metabolites of ethinylestradiol are excreted in urine and in bile in a ratio of 4: 6. Time of selling metabolic waste is about 1 day.

Before taking Marvelon Bayer is used for contraception (1 blister x 21 tablets)

How to use

oral drugs.

Dosage

The first tablet of the first blister on the first day of menstruation and drink 1 tablet daily at a certain period of time for 21 consecutive days. After a 7 -day break, do not take the drug, start drinking to the next blister. Usually bleeding (menstruation) on the 2nd - 3rd day after taking the last tablet and may not end the bleeding until the beginning of the next new drug.

After birth, if not breastfeeding, you can start taking the medication immediately. In this case, there is no need to use additional methods of contraception.

If you want to move your menstrual day, you should start the new Marvelon blister on the next day taking the last tablet of the old Marvelon blister and continue taking this blister as guided.

When you want to have a period, stop taking the medicine. Menstrual menstruation will appear within a few days after stopping the drug. Start taking a new medication after 7 days of stopping the drug without having to care about your menstrual period.

If you want to get pregnant, you should stop taking Marvelon.

Switch from other contraception to using Marvelon:

No contraceptive method contains hormones (in the previous month): Start taking the medication on the first day of menstruation. Can be taken on the 2nd - 5th day but need to use additional diaphragm measures for the first 7 days of medication.

Transferred from other contraceptive methods (other combined contraceptive pill (TVTTP), IUD or contraceptive stickers) to use Marvelon: It is best to start taking Marvelon right after taking the pills that the woman is taking. In the event that a woman is using an IUD or a contraceptive patch, it is best to start using Marvelon right after the day of removing the IUD or contraceptive stickers. After the first 3 months of miscarriage can use Marvelon immediately without any contraception.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget 1 dose? Next tablet taken at usual time.

If forgetting less than 12 hours, the contraceptive effect is still good. If you forget more than 12 hours, you need to use additional methods of additional contraception in the first 7 days or until the beginning of menstruation.

Side Effects

When using Marvelon, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Depression, change in personality, headache, nausea, abdominal pain, breast pain, breast tightness, weight gain.

Uncommon, 1/1000

Keeping water, reducing libido, migraine, vomiting, diarrhea, rash, urticaria, bigger breasts.

Rare, 1/10000

Hypersensitivity, increased libido, no contact lenses, erythema, polymorphic erythema, vaginal secretion, breast fluid, weight loss.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Marvelon drugs are contraindicated in the following cases:

Pathology or history of thrombosis/static switch/artery (such as deep vein thrombosis, pulmonary embolism, myocardial infarction) or stroke.

Pathology or history of blood thrombosis (ischemic, angina). It is known that there are factors that tend to cause static thrombosis/arteries with or non -genetic related to activated C protein, deficiency of antithrombin III, deficiency of C protein, Homocysteine ​​increase in blood and anti -phospholipid antibodies (anti -cardilipin antibodies, IUPUs anticoagulants).

History of migraine.

Diabetes with vascular damage.

There is a serious risk factor or many risk factors for venous thrombosis/artery.

Pancreatitis or a history related to blood triglycerides.

Liver pathology with abnormal liver function, liver tumor (healthy or malignant).

Knowing or suspecting malignant influence of sex steroids (such as genital or breast).

Vaginal hemorrhage is unknown.

Hypersensitivity to the ingredients of the drug.

Precautions when using

circulatory disorders

Rarely increases the risk of thrombosis/vein such as myocardial infarction, stroke, deep vein thrombosis, pulmonary embolism. Using any oral contraceptive pills also increases the risk of venous obstruction due to thrombosis such as deep veins and/or pulmonary embolism. Very rarely occur in other blood vessels such as dynamic/liver veins, hanging, kidneys, brain, retina.

Symptoms of thrombosis/turbulence due to static thrombosis/artery or stroke include: pain or swelling of one leg, sudden severe pain in the chest/without pain spread to the left hand, difficulty breathing, coughing suddenly, many headaches, abnormal and prolonged, suddenly lost or part of the vision, but the tongue is not accompanied by the body, dizziness is not accompanied or part of the body, movement disorders, acute abdominal pain.

The risk of blood tyranny in static/artery, stroke increases with: increased age, smoking, family history, overweight, blood lipoprotein disorders, hypertension, migraine, valve disease, atrial fibrillation, long -term motion, surgery/surgery in the leg, large trauma, surface inflammation and varicose veins.

Other pathological conditions combined with adverse circulatory complications include: diabetes, systemic erythematosus lupus, blood urea hyperur syndrome due to hemolytic, chronic colitis and increased growing red blood cell anemia when using TVTTPT.

Tumor tumor

For long -term use of the TTTP can increase the risk of cervical cancer, breast cancer. Some rare cases of benign liver tumors and more rarely are malignant tumors, which have been reported in TV user.

Women with hyperglyceride blood or family history can increase the risk of pancreatitis when using TVTTPH.

Blood pressure can increase slightly when using TVTP.

Acute or chronic liver dysfunction needs to stop using TV.

Be cautious with galactose intolerance.

Melasma can occur, especially in patients with a history of melasma, so avoid sunlight while taking the drug.

Before using Marvelon, you should ask for a medical history and be eliminated to get pregnant. Blood pressure should be measured and physical examination.

The ability to drive and operate machinery

No report.

Pregnancy

Not for pregnant or suspected pregnant people.

Breastfeeding period

Birth control pills containing estrogen/progestogen may affect the composition of breast milk and reduce milk secretion. An active ingredient can excrete in breast milk.

Drug interaction

No report.

Storage

temperature below 30ºC, avoid moisture and light.

Other drugs

Disclaimer

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