Maxdotyl hard capsules 50mg domesco treat anxiety in adults (2 blisters x 15 tablets)

Dosage form Box of 2 blisters x 15 tablets
Specifications Sulpiride

Ingredient

Composition information	Content
Sulpiride	50mg

Uses

Indications

Sulpiride is indicated in the following cases:

Symptomatic treatment anxiety in adults in case of not responding to normal treatments.

ATC code: n05al01

Sulpidi belongs to the benzamid group, which has an anti -mental effect through selecting the Dopamine D2 receptor in the brain.

can be considered sulpid as an intermediate medication between neuroleptic and antidepressants, because sulpides have both effects.

Contrary to the majority of other neurolysis drugs that closed both Dopamine D and D2 receptors, Sulpidi has a more selective effect and is mainly a Dopamine antagonist D2.

Sulpidi proved to not work on norepinephrin receptors, acetylcholin , serotonin, histamine, or gamma aminobutyric acid (GABA).

Side effects are relatively low and maybe some other side effects of sulpides are thought to be due to the specificity of Sulpid's Dopamine D2 receptor.

This selective property has led to this drug research to treat patients with late dysplasia. There are some evidence that low -dose sulpides (50 to 150mg/day) have antidepressant effects, and higher doses (800mg/day to 1000mg/day) have the effect of positive symptoms of schizophrenia.

The antidepressant effect of low -dose sulpides is said to mainly seal the dopamine receptors, with dopamine transmission activation.

Sulpid also stimulates prolactin secretion, the drug has been studied in treatment without breast milk and to improve birth control pills when using progestin.

Because Sulpidi has been shown to improve blood flow and mucus in the peptic mucosa, the drug has also been studied to treat duodenal ulcer.

The drug also has anti -vomiting and drugs that have also been used to treat dizziness, migraine.

So far, data is not enough to assess the sulpided position in the treatment of other neurological diseases, depression , mind disease, lack of breast milk or peptic ulcer.

All studies on sulpides are above a small number of patients who are not enough to assess the effectiveness and safety of the drug.

Select blockade effects Dopamine D2 receptors of Sulpidi have not shown to reduce many extrasic side effects and other side effects.

Late dysfunction has also been notified. So far, studies on the treatment of schizophrenia have not shown that the use of sulpides has more clinical benefits than other neuroleptics.

pharmacokinetic

absorption

Sulpidi is slowly absorbed from the digestive tract.

After taking a 50mg capsule, the peak concentration of sulpid in plasma is achieved in the order of 0.73mg/liter and 0.25mg/liter in 3-6 hours.

Oral use from 25% to 35%, a lot of change among patients.

After taking doses from 50mg to 300mg, Sulpidi pharmacokinetics vary by linear.

Distribution

Sulpidi is quickly distributed into tissues but absorbs less through the brain barrier. Distribution volume: 0.94 liters/kg.

The ratio of protein is about 40%. Sulpidi is distributed into breast milk and through the placenta.

Sulpidi metabolizes less in humans.

Elimination

Sulpidi is mainly through glomerular filtration.

Whole clearance

126ml/min. Sell waste time in the plasma of the drug is about 8 - 9 hours.

Before taking Maxdotyl hard capsules 50mg domesco treat anxiety in adults (2 blisters x 15 tablets)

How to use

use oral, so start with the lowest dose and increase gradually when needed.

Dosage

always have to take the medication as the doctor prescribed.

If you are not sure, ask the doctor again. Continue to use the drug as directed by your doctor even if you feel better.

If you stop the medication too early, you can relapse.

Please report to your doctor if you feel the drug has a strong or not strong effect.

Common dose:

Adults:

Treatment of acute anxiety in adults in case of not responding to conventional treatments: daily dose from 50 - 150mg in 4 weeks.

Children over 6 years old:

Severe behavioral disorders (agitated, self -hurting, imitating) in children over 6 years old in autism syndrome: Daily dose from 5 - 10mg/kg.

Elderly:

Dosage for the elderly is the same as adults, but the starting dose is always low and increasing.

Starting 50 - 100mg/time, 2 times a day, later increasing to effective dose.

People with kidney failure:

Must reduce the dose or increase the distance between drug use depending on the clearinine clearance.

Creatinine clearance 30 - 60ml/minute: use the dose equal to 2/3 of the normal dose.

Creatinine clearance 10 - 30ml/minute: use a dose equal to 1/2 of normal dose.

The clearance of less than 10ml/minute: using a dose equal to 1/3 of the normal dose.

or may increase the distance between the doses is 1.5, 2 and 3 times compared to normal people.

However, in case of medium and severe renal failure should not use sulpides, if possible.

What to do when overdose?

Experience overdose sulpirir is still small. When an overdose may be disturbed with muscle disorders in the tongue and jaw hard.

Some patients have worse Parkinson's similar syndrome, and a neuroleptic syndrome. Sulpidi eliminates partially through hemolysis.

How to overdose

If you or anyone else (such as children) take too many pills, see the doctor or go to the recovery department - emergency of the nearest hospital.

There is no specific antidote. Symptomatic treatment. Cardiovascular respiratory resuscitation, continuous monitoring until recovery (prolonged QT risk and ventricular arrhythmia).

If a severe surgeon syndrome appears, a cholinergic drug may appear.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

Like other drugs, Maxdotyl 50mg can cause side effects, although not all patients encounter.

Notice immediately to the doctor or pharmacist unwanted effects when using the drug.

If any unwanted effect becomes serious or if you detect unwanted effects that have not been mentioned in this tutorial, report to your doctor.

Sulpidi is well tolerated. When using the treatment dose, unwanted effects are often lighter than other anti -psychotic drugs.

The frequency of emergence of unwanted effects is defined as follows: Common (ADR> 1/100); rarely (1/1000

Summary of unwanted effects:

Agencies

Frequency

Unwanted reactions

Common

Insomnia or drowsiness.

Excessive stimulation, extracurricular syndrome (sitting restless, crooked neck, eye rotation), Parkinson's syndrome.

Late dysfunction, malignant high fever syndrome caused by neuroleptics.

Endocrine

Common

increased blood prolactin, increased milk secretion, menstrual disorders or amenorrhea.

Big breasts in men.

Less

Prolonged qt distance (causing arrhythmia, torsion).

blood pressure

Rare

Hypotension Standing, slow heart rate or arrhythmia.

Other

Rare

Lower body heat, sensitive to light, jaundice due to bile stasis.

Unwanted effects are often light and less occur. If there is a surgeon syndrome may reduce the dose or take anti -Parkinson anti -cholinergic drugs. If there is a manifestation of malignant high fever syndrome, the drug must be stopped immediately. Preventing the torsion to avoid coordinating with drugs that reduce potassium, or extend the QT range.

Warnings

Contraindications

Hypersensitivity to sulpides or any ingredients of the drug.

adrenal marrow.

Granting porphyrin metabolism disorders.

The central nervous state is inhibited, comatose, alcohol poisoning and neurological inhibitors.

Prolactin dependent tumors (such as adenoma pituitary glands and breast cancer).

Combined with mequitazin, dopamine, vibrating drugs - Parkinson (Cabergolin, Quinagolid, Rotigotin), Citalopram and Escitalopram.

Children under 6 years old.

Precautions when taking drugs

Must be cautious when taking sulpides because the drug can cause malignant syndrome caused by neuroleptic.

During treatment, if high fever is unknown, it is necessary to stop the drug immediately because high fever may be a manifestation of malignant syndrome caused by neuroleptics.

Sulpidi extends the QT range, depending on the dose.

This effect increases the risk of heavy arrhythmia, especially the peak, especially when there is a bradycardia

Be cautious when using sulpides for the elderly, especially when dementia, when there are risk factors for stroke because it is prone to hypotension, easy to fall, sleepy, and the effect.

The risk of death often increases when taking anti -psychotic drugs at this age.

Must monitor blood glucose for people with diabetes or risk diabetes at the beginning of sulpida treatment.

In cases of renal failure, sulpider dose is needed and increased monitoring. If the renal failure is severe, it is recommended to treat each interrupt batch.

Need to strengthen monitoring of the following objects:

People with epilepsy because they are likely to be lowered.

The ability to drive and operate machinery

The drug can cause drowsiness, so do not use when operating machinery, driving train, working on high and other cases.

Pregnancy and lactation

Pregnancy

Maintaining a psychological balance for mothers during pregnancy is desired. If you need to use the drug to maintain that balance, medication must be taken or continue to take the drug in effective doses throughout the pregnancy.

Monitoring pregnant mothers who have not seen any special deformities due to sulpides.

Although there is no case described in infants, but in theory, if they continue to use at the end of pregnancy, especially the use of sulpided rubber can cause: fast heart, increase stimulation, abdominal distention, slow manual, muscle tone, tremor, sleep.

Therefore, Sulpidi can be used at any stage during pregnancy.

Must monitor babies to detect the above symptoms.

Breastfeeding period

Sulpidi is distributed into breast milk in relatively large amounts and can cause unwanted reactions for breastfed babies.

So women who are breastfeeding should not be used or stop breastfeeding if used.

Other special subjects (elderly, children, allergies)

Do not use for children under 6 years old.

Drug interaction

Food:

Alcohol increases the sleeping effect of the drug, so avoid drinking alcohol and alcoholic drinks while using sulpides. Loss of consciousness when driving, operating machinery.

Use other drugs:

Information with the doctor lists all the drugs you are using.

Contraindicated to use sulpides with mequitazin, citalopram, Escitalopram:

Increases the risk of ventricular arrhythmia, including peak twisted. Bromocriptin, Entacapon, Lisurid, Perolid, Piribedil, Pramipexol, Ropinirol, Selegilin): Mutual opposition between dopamine and neuroleptic. Parkinson is being treated with dopamine, dopamine dose must be gradually reduced until stopped completely (if this drug is stopped suddenly, there is a risk of malignant syndrome caused by a neural drug).

sedative:

Morphin's derivatives (analgesic, anti -cough, replacement), neurony drugs, barbiturates.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer.

You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist.

Keep pills out of reach of children and pets.

Expiry date: 36 months from the date of manufacture.

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