Maxx acne-acne Ampharco U.S.A gel for acne treatment (15g)

Dosage form Tube
Specifications Adapalene, clindamycin

Ingredient

Composition information	Content
Adapalene	0.1%
Clindamycin	1%

Uses

Indications

Maxx acne-acputs are indicated in the following cases: The drug is used on the skin to treat acne in the face, chest and back that has been infected and does not respond to antibiotic treatment, especially with many blackheads, acne, pustules.

Pharmacokological

Maxx acne-AC skin gel contains clindamycin phosphate, this substance is hydrolyzed in the skin into the active clindamycin form. Clindamycin is the Lincosamid antibiotic with the main bactericidal effects are Gram -positive aerobic bacteria and anaerobic bacteria.

Clindamycin penetrates into blackheads (acne) appears on the skin and destroys infected bacteria on acne -prone skin, cleanses and prevents widespread infections. In vitro, clindamycin inhibits all testibacterium acnes testibacterium implants (0.4MCG/ml). The free fatty acids on the skin surface decreased from 14% to about 2% after the drug. Adapalen is a retinoid compound, chemically stable. Biochemical and pharmacological research has shown that Adapalen is a substance that regulates the process of differentiation of cells, horns and inflammatory processes, all three processes are important characteristics in acne learning. It works by affecting the growth of cells and reducing swelling and inflammation.

In terms of action mechanism, Adapalen is in association with specific retinoic receptors of the nucleus, but does not connect with the receptor protein in the cytoplasm. Although it is not known the exact mechanism of adapalen, it is thought that adapalen is applied to the skin that can help normalize the differentiation of cystic cells and thus reduces the formation of acne micro.

pharmacokinetics

absorption - Distribution

After being used on the spot multiple times clindamycin phosphate with a concentration equivalent to 10 mg/ml clindamycin, Clindamycin concentration is present in very low plasma (0 - 3ng/ml) and less than 0.2% the dose found in urine in the form of clindamycin.

In humans, adapalen absorbs through poor skin. Only a small amount (

Metabolism

Clindamycin phosphate converts into clindamycin in the skin and clindamycin metabolized mainly in the liver through the n-ha-hagemylation, sulfur oxidation and hydrolysis

Adapalen is metabolized mainly according to methylation reduction reactions, hydroxylation and combinations.

Elimination

Clindamycin is excreted mainly through the bile.

Adapalen is excreted mainly through the bile.

Before taking Maxx acne-acne Ampharco U.S.A gel for acne treatment (15g)

How to use

This drug is only used outside the skin for adults and children aged 12 and older.

Dosage

Maxx acne-AC skin gel should be used once a day on acne-prone skin after washing in the evening before going to bed. A thin layer of gel should be applied, avoiding contact with the eyes, lips, and mucosa. Do not apply medicine to the skin torn, scratched, burn, or eczema. Avoid exposure to sunlight and avoid using creams, oil makeup products or corrosive cosmetics.

In the first weeks of treatment, there may be a batch of acne. This is due to the effects of drugs on previous lesions and should not stop treating for this reason. The results are usually clearly seen after 8 to 12 weeks. Treatment time should be limited to about 12 weeks.

What to do when using overdose? Applying too much medicine does not bring more results faster or better but can cause redness, peeling, or significant discomfort. The oral dosage of Adapalen Gel in mice is greater than 10 ml/kg. Taking prolonged medication can lead to side effects like those who overdose vitamin A.

Clindamycin gel preparation gel format can be absorbed enough to cause systemic effect.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

In the process of using Maxx Acne-AC, some unwanted side effects may be encountered:

Patients may have a feeling of heat or throbbing immediately after applying the drug. Skin redness, dryness, itching, flaking, slight burning sensation, or severe acne can occur in the first 2-4 weeks to use the drug, this effect often decreases when continuing to use the drug. Inform the doctor or pharmacist as soon as any of these effects still exist or worsen.

Common (ADR> 1/100)

Dry skin, skin irritation, burning sensation, redness, irritation around the eyes, acne emitting, itching.

Less (1/1000

contact dermatitis, skin discomfort, severe burns, scales, skin pain, scales.

unknown (not estimated frequency from existing data):

Swelling in the skin, irritation, redness, itching or swelling in the eyelids.

Clindamycin can lead to severe dysentine colitis. Cases of diarrhea, bloody diarrhea and colitis (including fake colitis) have been reported as unwanted effects on patients treated with clindamycin used on the skin.

Other adultery effects are reported with the use of clindamycin applied to the skin including: abdominal pain, digestive contact dermatitis, gram -negative bacterial folliculitis, irritation, oily, sensitive skin. Notify the doctor with adverse effects encountered when taking the drug.

Warnings

Contraindicated

Maxx acne-AC drug contraindicated in the following cases:

Do not use Maxx acne-ac gel for people who are sensitive to Adapalen, Clindamycin, Lincomycin, or any ingredients in excipients and should not share oral or applied drugs containing erythromycin.

Contraindicated, Maxx Acne-AC skin gel for patients with a history of localized bowelitis or ulcerative colitis, or colitis due to antibiotic or Crohn disease.

Precautions when using

In the process of using Maxx Acne-AC, you need to be cautious in the following cases:

If you record hypersensitivity to any component of the drug or the reaction, the sensitivity, chemical irritation occurs, should stop using the drug. People who are often exposed to the sun and those who are sensitive to the sun should be alerted carefully when used. Use sunscreen products and protective clothing on treated skin areas when unavoidable. Patients with sunburns should not use the product until completely recovered.

Avoid contact with eyes, lips, corner of the nose, and mucosa. Do not apply this medicine to the skin that is torn, scratched, eczema, or severe skin burns. These symptoms usually occur in the first 2-4 weeks and often decrease when continuing to use the drug. Depending on the severity of the side effects, patients may be instructed to reduce the number of drugs or stop use. Diarrhea, bloody diarrhea or colitis (including fake colitis) has been reported when using clindamycin on the skin. Should stop the drug when severe diarrhea. Consider applying colonoscopy to determine the diagnosis in case of severe diarrhea. The solution is uncomfortable and should be careful when applying the drug around the mouth. Should be careful when indicated to use clindamycin for people with allergies.

The ability to drive and operate machinery

The drug hardly affects the ability to drive and operate machinery.

Pregnancy

There are not enough control studies in pregnant women. This medication should only be used during pregnancy when the benefits are higher than the potential risks for the fetus.

Breastfeeding period

The excretion of the drug through breast milk is unknown. Because there are many drugs excreted through breast milk, be careful when taking this medication for nursing women.

Medicinal interaction

because this drug has the ability to cause local irritation in some patients, be careful in simultaneous use of skin -to -skin products that can cause irritation (drugs or soap and detergents with corrosive properties, soap and fast drying cosmetics, and products with high alcohol content, astringent, spice or water). Especially need to be cautious in using sulfur, resorcinol or salicylic acid in combination with adapalen gel. If these preparations have been used, the patient is advised not to start treating with Adapalen Gel until the effects on the skin of these preparations have decreased.

Cosmetics that do not cause blackheads or dry skin can be used. Determined the cross resistance between clindamycin and lincomycin. The antagonism has been determined between clindamycin and erythromycin. Clindamycin has shown neuromuscular inhibition properties, which can increase the impact of neurotransmitter medications. Therefore, note when using clindamycin for patients who are taking the above drugs.

Storage

temperature below 30 ° C. Avoid direct light and wet place.

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