Mebaal-1500 mega We Care tablets treat peripheral neuropathy (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Methylcobalamin

Ingredient

Composition information	Content
Methylcobalamin	1500mcg

Uses

Indications

Mebaal 1500 mega 3 x 10 drug is indicated in the following cases:

Treatment of peripheral neuropathy such as diabetes, alcoholic neuropathy, medication, triple neuropathy and occupational neuralgia, Bells paralysis and large red blood cell anemia. Methionine creation from Homocystein.

mecobalamin is well transported into the minor of the nerve cells, increasing the synthesis of nucleic acid and protein. Animal research shows that mecobalamin is transported into the minor of the nerve cells better than the cyanocobalamin.

mecobalamine helps to enhance axon recovery. Experiments on animal nerve cells are experimented with streptozotocin diabetes show that mecobalamine helps restore the transmission speed of proteins in axon.

The experiments of neurological and physiological diseases show that mecobalamin prevents the degeneration of the mice causing experimental peripheral neuropathy with drugs such as Adriamycin, Acrylamid and Vincistin or in spontaneous diabetes with neurolithic degeneration due to peripheral neuropathy.

mecobalamin promotes myelinization (phospholipid synthesis), increasing the synthesis of lecithin, a major component of myelin bag. In an animal tissue culture environment, the process of neuron myelin in the environment has higher mecobalamin than cobalamin.

mecobalamin helps restore neurotransmitters (both the speed and number of transmission substances). Mecobalamin helps to restore the ending potential by increasing stimulation of the nerves in the puppet nerves. In addition, mecobalamin also works to restore acetylcholin concentration in brain cells in animals for dietary dietary cholin.

mecobalamin stimulates the maturity and division of the Red blood cells, reducing anemia. Mecobalamine helps increase nucleic acid synthesis in bone marrow, while stimulating the maturity and division of the Red blood cells, increasing the number of red blood cells.

mecobalamin has the effect of quick recovery of indicators such as the number of red blood cells, hemoglobin and hematocrit animal anemia due to vitamin B12 deficiency.

pharmacokinetics

endogenous vitamin B12 produced from protein in the stomach thanks to the effect of acid and pepsin, including mecobalamine and adenosylcobalamin.

In the stomach, they coordinated with Haptocorrin protein or r protein, protein due to salivary glands and stomach lining. In the small intestine, the pancreatic protease decomposes a part of the cobalamin-Haptocorrin complex, where the released cobalamin will be connected to the internal factor (Intrinsic Factor-one lungcoprotein secreted by the stomach cells into the stomach cell). The cobalamin-inner coal complex is absorbed from the ileum into the cell by connecting to the receptor.

In cells, cobalamin is released from the cobalamin-inner element complex and cohesion with Transcobalamin II and is included in the circulatory port. The cobalamin is then transferred to the liver, about 50% is stored in the liver, the rest according to the common circulation to the tissue in the body.

Cobalamin-transcobalamin II complex is decomposed by enzymes that decomposes protein in cell pepper to form cobalamin (cyanocobalamin, mecobalamin, adenosylcobalamin, hydroxocobalamin).

Cobalamin is converted into mecobalamin in the cytoplasm and adenosylcobalamin into mitochondria. Mecobalamin is the main form of Cobalamin. The total amount of cobalamine in the body is about 2-3 mg, about 50% concentrated in the liver.

In plasma, mecobalamin associated with transcobalamin I (TCI), Transcobalamin II (TC II) and Transcobalamin III (TC III), about 80% associated with TC I. Only TCII has the ability to transport vitamin B12 into tissue, thanks to specific receptors with TC II. TC II is the main factor that brings vitamin B12 from cells absorbed to the circulatory gate.

Total absorption increases proportional to the amount of vitamins introduced. However, bioavailability is reduced when the dose increases, even only about 1% when using high doses of mecobalamin. Absorb according to passive diffuser mechanism is achieved even without internal factors. Therefore, it is possible to specify high doses instead of injection (usually intramuscular). Currently, there are a number of studies to prove the above statement. Mecobalamin's bioavailability from food is about 50%.

mecobalamin is stored in the bile and is reabsorbed through the intestinal cycle, some are excreted in the feces.

The rest is not absorbed (when used by oral) will also be excreted in the feces.

Mecobalamine reabsorption process through the bowel cycle does not need intrinsic factors.

When vitamin B12 concentration exceeds the ability to bind the blood, is common when using the injection, the excess amount will be excreted in the urine.

Before taking Mebaal-1500 mega We Care tablets treat peripheral neuropathy (3 blisters x 10 tablets)

How to use

Mebaal 1500 mega 3 x 10 medicine is taken orally.

Dosage

The usual dose of adults is 1 Mebaal 500/time, 3 times/day or 1 Mebaal 1500/day. Dosage can be adjusted depending on the age of the patient and the severity of the symptoms.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Mebaal 1500, you may experience unwanted effects (ADR).

Not delicious, nausea, diarrhea or other digestive disorders may occur after the drug.

Notify the doctor of unwanted effects when using the drug.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Mebaal 1500 mega 3 x 10 drug is contraindicated in cases of hypersensitivity to mecobalamin or any ingredients of the drug.

Caution when using

Mecobalamin supplementation in case of lack or to treat the disease requires the monitoring of a physician. Mecobalamin should not be used for a long time (over 1 month) if not responded after treatment.

The ability to drive and operate machinery

There has been no drug report that affects the ability to drive and operate machinery.

Pregnancy

only used when prescribed by a doctor.

Breastfeeding period

Medicinal interaction

Antibiotics: Using antibiotics can change the intestinal microflora and reduce the effects of mecobalamin on the body's vitamin needs (due to some microbiological strains available in the intestine such as Lactobacilus Species), especially in vegetarians. Onions, garlic, leeks, bananas, asparagus and artis, some fruits and vegetables containing Inulins can promote the development of some bacterial strains in the colon, including Lactobacilus

Cholestyramin, Colchicin, Colestipol: can reduce the ability to reabsorb mecobalamin through the gut liver cycle.

H2 inhibitors (cimetidine, famotidin, nizatidine, ranitidin): Using regular H2 inhibitors can reduce mecobalamine absorption, which does not occur with cobalamin.

metformin: Meformin can reduce mecobalamin absorption. This effect can be reversed when adding oral calcium.

Nitrous oxide (N2O): Inhalation of nitrous oxid anesthesia (not full) can lead to functional failure.

nitrious oxid creates a complex with mecobalamin's cobalt, a methomin synthetic cofactor, the result of enzyme inactivity.

Para-amino salicylic acid: regular use of antacids can reduce mecobalamin absorption.

Potassium chloride: There have been a number of reports that potassium chloride can reduce absorption in some cases.

Proton pump inhibitors (Lansoprazol, omeprazol, Pantoprazol, Rabeprazol): regular use of proton pump inhibitors can reduce absorption.

Storage

Store in cool dry places, below 30 ° C. Avoid light and avoid moisture.

Expiry date: 30 months from the date of manufacture. Do not use overdue drugs stated on the packaging.

Note: Read the instructions carefully before use. If you need more information, please consult a doctor. To be out of reach of children.

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