MECEFIX-B.E 200mg Merap Treatment of urinary tract infections, otitis media (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Cefixime

Ingredient

Composition information	Content
Cefixime	200mg

Uses

indication

Treatment of the following infections caused by sensitive bacteria:

Infectious respiratory infections: bacterial pharyngitis, tonsillitis , otitis media, sinusitis.

Lower respiratory infections: acute bronchitis and acute attacks of chronic bronchitis.

Uncomplicated urinary tract infections: Acute cystitis.

Without complications.

Pharmacokological

cefixim is an antibacterial antibiotic and stabilized under the hydrolysis of many beta - lactamase. Cefixim is the third -generation cephalosporin antibiotic, bactericidal mechanism is inhibiting the synthesis of bacterial cells.

antibacterial spectrum includes:

Gram -positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes.

Gram -negative bacteria: Haemophilus Influenzae (Laca secretion and non -secretion - lactamase), Moraxella (Branhamella) Catnrhalis (mostly beta - lactamase), Escherichia coli, Proteus Mirabilis, Neisseria Gonorrhoeae (Including secret and air and air penicilinase).

Cefixim is active for most of the following bacteria strains on in vitro, but the clinical effect has not been verified:

Gram -positive bacteria: Streptococcus agalactiae.

Gram -negative bacteria: Haemophilus parainfluenzae (strains and no beta - lactamase), Proteus vulgaris, Klebsiella Pneumoniae, Klebsiella Oxytoca, Pasteurella Species, Salmonella Species, Shigella Species, Citrobacter Amalonathatic, Citrobacteric Diversus, Serratia Marcescens.

Note: Pseudomonas species, strains strains of D group D (including Enterococci), Listeria Monocytogenes, most staphylococci strains (including methicillin strains) and most antobacter strains of resistance to cefixim. In addition, most bacterioides Fragilis strains and Clostridia resistance Cefixim.

Pharmacokinetics

absorption

Cefixim is used orally, absorbed by 40-50%, when there is food, the maximum absorption time increases 0.8 hours.

Distribution

About 65% Cefixim in the blood is attached to plasma proteins.

Elimination

About 20% of oral doses are eliminated in the form of unchanged urine for 24 hours.

Before taking MECEFIX-B.E 200mg Merap Treatment of urinary tract infections, otitis media (2 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults and children over 12 years old

Dosage recommended 200 - 400 mg daily, use a single dose or divided into 2 times.

Intractive respiratory infections and uncomplicated urinary tract infections: 200 mg/day/day.

Sinusitis case: Must be used for treatment from 10 to 14 days.

Inhan complication treatment: The recommended dose is 400 mg orally 1 time.

Children under 12 years old

The suggested dose is 8 mg/kg per day, using a single dose or divided into 2 times, patients with more severe or incomplete symptoms, which may increase the dose to 6 mg/kg twice daily.

The weight of children (kg)

Dosage/day (mg)

6,25

12.5

100

18.75

150

200

31,25

250

300

recommended dose at adult dose.

Patients with renal failure

Should reduce the dose in patients with severe to severe renal failure. For patients with kidney failure with creatinine clearance below 20 ml/min, the dose does not exceed 200 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, there is no specific antidote. Cefixim must not be removed from the blood of a large amount of hemorrhage or peritoneal fertilizer. Side reactions on a small number of healthy volunteers when taking only 2 g cefixim dose are no different from the recommended dose patients.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using MECEFIX B.E 200 you may experience some unwanted effects (ADR).

Common, ADR> 1/100

No report.

Uncommon, 1/1000

No report.

Not determined frequency

Digestive: diarrhea , abdominal pain, indigestion, nausea and vomiting, fake colitis.

skin: skin rash, urticaria, drug fever, itching, polymorphic erythema, Stevens - Johnson syndrome , serum -like reaction.

Liver: temporary increase SGPT, SGOT and alkaline phosphatase.

kidney: temporary Bun or Creatinine.

Central nervous system: headache or dizziness.

Blood and lymphatic system: Eosin hypernagus, leukopenia and reduced fleeting platelets. Prothrombin is rarely encountered.

Other side effects: Genital itching, vaginitis, Candida fungus.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

MECEFIX B.E 200 drugs in the following cases:

cefixim contraindicated for patients who have known allergies to antibiotics of cephalosporin groups.

Be cautious when used

Caution for patients with previous allergic reactions with cephalosporin, penicillin. The ratio of cross -allergy between beta - lactam antibiotics and patients with a history of penicillin allergies may occur.

Note the ability to develop resistance bacteria that can be due to excessive growth, especially long -term treatment.

Safety and efficiency when using Cefixim for children under 6 months old is not recorded, so be careful for children under 6 months of age.

Caution in patients with a history of digestive disease, especially colitis.

The ability to drive and operate machinery

The drug can cause dizziness headaches, so be careful when using the drug for the driver and operating machinery.

Pregnancy

Safe for pregnant women has not been verified, only used when necessary.

The period of breastfeeding

It is not known whether the cefixim will be in human milk or not, only used when it is really necessary.

Drug interaction

Increased carbamazepine concentration has been reported when used simultaneously Cefixim.

The false direct positive cooom test has been reported while treating with other cephalosporin antibiotics, so it should be realized that positive CoAMB test may be due to drugs.

Anticoagulants: There has been a report to increase prothrombine time after using Cefixim simultaneously with anticoagulant drugs (such as warfarin).

Storage

Temperature does not exceed 30 ° C.

Other drugs

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