Mecosol 40mg Mediplantex hard capsules treat reflux - gastroesophageal, esophagus (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Esomeprazol

Ingredient

Composition information	Content
Esomeprazol	40mg

Uses

indications

Mecosol medicine is indicated in the following cases:

Gastroesophageal reflux disease - severe esophagus (scratched esophagitis, ulcers or narrowed lines is determined by laparoscopy). The stomach is due to inhibition of h '/k atpase enzyme. Esomeprazol is the isomorphic S-S-Omeprazole, when entering the body at the pH

pharmacokinetic

absorption

Esomeprazol absorbs rapidly through the gastrointestinal tract, the peak concentration in plasma is achieved after 1-2 hours.

Increased bioavailability depends on the dose and repeated use, about 68% - 89% for the dose of 20mg and 40mg respectively. Food slows down and reduces the absorption of the drug, although this does not significantly affect the effects of Esomeprazol on gastric acid secretion.

Distribution

Esomeprazol binds 97% to plasma proteins.

Metabolism and excretion

Esomeprazol is completely metabolized through the liver thanks to the Cytochrome P450 (CYP) system.

Most of the metabolism of Esomeprazol depends on the CYP2C19 enzyme, forming hydroxy and desimethyl metabolites of Esomeprazol - substances that do not affect gastric acid secretion. The rest of the metabolic process depends on the CYP3A4 enzyme, forming Esomeprazol Sulphone.

The process of metabolism through the liver for the first time and the body clearance decreases when the dose is repeated, the cause may be due to the inhibition of CYP2C19. However, Esomeprazol completely eliminated from plasma between doses without accumulation when used 1 time/day.

Selling time for plasma is about 1.3 hours. About 80% of Esomeprazol is excreted in urine in the form of metabolites, the rest is eliminated in feces.

Before taking Mecosol 40mg Mediplantex hard capsules treat reflux - gastroesophageal, esophagus (1 blister x 10 tablets)

How to use

oral Esomeprazol for at least 1 hour before eating, swallowing pills, not chewing or grinding pellet.

Dosage

Adults and children> 18 years old:

Esophagitis inflammation due to reflux: 1 tablet/day for 4 weeks. Should treat 4 more weeks for patients with untreated esophagitis or persistent symptoms.

Stomach ulcer - duodenum: 1 tablet/day, drink for 4 - 8 weeks.

Prevention and treatment of stomach - duodenal ulcer due to Helicobacter pylori infection: Combined with appropriate antibacterial regimen to eradicate Helicobacter pylori: 1 tablet/day for 7 - 10 days.

Treatment of Zollinger - Ellison syndrome: Start 1 tablet/day, then adjust to response. Most patients are controlled at a dose of 2-4 tablets/day, divided 2 times.

Elderly, kidney failure, mild to moderate liver failure: No dose adjustment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

The oral dose of 160mg/time is still well tolerated. When using a high doses up to 2400mg, the symptoms occur very diverse, including confusion, drowsiness, blurred vision, fast heart, nausea, sweating, redness, headache and dry mouth.

Handling

There is no specific antidote. In case of overdose, symptomatic treatment and use of supportive measures should be used.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, you may experience unwanted effects (ADR).

Common: headache, abdominal pain, diarrhea , nausea, vomiting, constipation. Bronchial, sore throat, hepatitis or non -jaundice, sensitive to light, muscle pain, baldness, joint pain, difficulty living, increased sweating.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindications in the following cases:

History of hypersensitivity to Esomeprazol, substances belonging to the Benzimidazole group or any component of the drug.

Be cautious when using

Eliminate malignant gastric disease before taking Esomeprazol because the drug can cover symptoms and delay in diagnosis.

Be cautious when used for prolonged use because it can cause stomach atrophy.

The ability to drive and operate machinery

Unused because Esomeprazol can cause headaches, dizziness, sleeping chicken.

Pregnancy and lactation

Pregnancy

Should be cautious when prescribing Esomeprazol for pregnant women.

Breastfeeding period

Do not use esomeprazol while breastfeeding.

Drug interaction

drugs that have absorption depends on the stomach pH

Simultaneous use of Esomeprazol with drugs with a mechanism of absorption dependent stomach acid such as ketoconazole, iTraconazole ... can reduce the absorption of these drugs.

Esomeprazol significantly reduces the concentration and AUC of Atazanavir. Increasing the dose of Atazanavir to 400mg has not compensated for the effects of ecomeprazol on the concentration and AUC of Atazanavir. Do not combine two drugs together.

Metabolic drugs by CYP2C19 enzyme

Concomitance Esomeprazol with metabolic drugs by CYP2C19 such as Diazepam, CitalPram, Imipramine, Clomipramine, Phenytoin ... as a concentration of these drugs in plasma can increase, need to decrease the dose.

Clinically, when using 40mg of Esomeprazol for patients who have used warfarin shows that blood clotting time is still within the allowed limit. However, some Inr increase cases have been reported when used in combination with warfarin with esomeprazol.

Esomeprazol has been shown to have no clinical effects on pharmacokinetics of amoxicillin or quinidine.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

Other drugs

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