Medexa 16mg pt medicine. Dexa Medica treats abnormalities with adrenal skin function (5 blisters x 6 tablets)

Dosage form Box of 5 blisters x 6 tablets
Specifications Methylprednisolone

Ingredient

Composition information	Content
Methylprednisolone	16mg

Uses

indications

Medexa drugs are indicated in the following cases: anti -inflammatory and immunodeficiency in rheumatoid arthritis, body lupus, vasculitis, bronchitis, chronic ulcerative ulcer , anemia immunity due to immunity, granulocytopenia, cancer, kidney syndrome.

Pharmacokology

Methylprednisolone is a glucocorticoid, derivative of prednisolone, which is the same active substance as the original substance. Methylprednisolone does not work to keep na like other glucocorticoids. Like other steroid hormones, corticosteroids act by controlling protein synthesis. However, their almost instant ACTH release inhibition may be an exception.

corticosteroid reacts with protein receptors in the cytoplasm of sensitive cells in many tissues to form a steroid receptor complex. This complex undergo a change, recorded by an increase in sedimentation constant, and then moving into the cell nucleus, attached to chromatin and adjusting the increase of the increase, manifested by increasing the number of specific mARN. However, Glucocorticoid also reduces the transcription of some genes, such as Pro - Opiomelanocortin gene coding ACTH.

pharmacokinetic

absorption

Most glucocorticoids are quickly absorbed when used orally like free alcohol, ceton, cypionate or acetate. After intramuscular injection, the absorption of sodium phosphate and sodium sucinate soluble in water is faster, the absorption speed of acetate and acetonide esters is much slower in fat. When it is necessary to start the fastest effect, the ester intravenous of glucocorticoids should be soluble in water. The whole body absorption occurs slowly after the injection in the joint, in the bag, in the epidemic bag, the endometrium, or in the soft tissue for most glucocorticoids.

After steaming through the mouth, glucocorticoids are absorbed from the gastrointestinal tract and respiratory tract.

Distribution

Research in animals shows that most glucocorticoids are removed from the blood quickly and are distributed into the muscles, liver, skin, intestines and kidneys.

Different glucocorticoids at a level combined with plasma proteins. Prednisolone (unlike other synthetic glucocorticoids such as betamethasone, dexamethasone or triamcinolone) have high affinity with transcortin and compete with cortisol for this protein combination. Because only drugs in the form of non -combination are pharmacological activity, patients with low serum albumin concentrations are more likely to be affected by the effect of glucocorticoid compared to patients with normal seral albumin levels.

glucocorticoid passes through the placenta and can go into breast milk.

Elimination

Glucocorticoid has a ceton group at C - 11 (such as cortisone, prednisone and meprednisone) that must be reduced (mainly in the liver) into homologous substances 11 - Hydroxy corresponding (hydrocortisone, prednisolone and meprednisolone) for pharmacological activity. Prednisone is rapidly transformed into prednisolone, but most cortisone is active before it is transformed into hydrocortisone.

Glucocorticoids with pharmacological activity are metabolized in most tissues, but mainly in the liver, into compounds without biological activity. Hydrocortisone's half -life may last for patients with thyroid disabilities. Inactive metabolites are excreted through the kidneys, mainly in the form of glucuronide and sulfate, but also in the form of no combination. Small amounts of non -metabolic drugs are also eliminated in urine. The negligible quantities of the majority of drugs are not metabolized in bile, hepatoma - intestinal circulation.

Before taking Medexa 16mg pt medicine. Dexa Medica treats abnormalities with adrenal skin function (5 blisters x 6 tablets)

How to use

drugs used by oral.

Take the tablet with a glass of water.

Dosage

Adults

Methylprednisolone starting dose may vary from 4 - 48mg/day.

Single dose or dosage depending on the condition being treated.

Acute asthma attack

methylprednisolone 32 to 48mg per day, for 5 days, can be treated with a lower doses in a week. When from acute asthma attack, methylprednisolone is gradually reduced.

rheumatoid arthritis

The starting dose is 4 to 6mg of methylprednisolone per day. During the acute phase, higher doses: 16 to 32mg/day, then gradually decreases.

Chronic ulcerative ulcer

Severe exacerbations: Take oral (8 to 24mg/day).

Nephrotic syndrome

The starting dose of methylprednisolone daily is 0.8 to 1.6mg/kg for 6 weeks, then gradually decreases the dose for 6 to 8 weeks.

Immune hemolyticemia

Using Methylprednisolone oral oral 64mg/day, for 3 days. Methylprednisolone must be treated for at least 6 to 8 weeks.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

There is no clinical syndrome on acute overdose when using methylprednisolone doses up to a few grams for 24 hours, although blood sugar and blood urge hyperkemen have been recorded.

Chronic overdose

After chronic overdose, it is necessary to prevent the possibility of adrenal inhibition by reducing the dose slowly for a while.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, you may experience unwanted effects (ADR).

Side effects occur when used for prolonged or high doses such as: Water - Electrolyte disorders, muscle weakness, slow healing of wounds, increased blood pressure, cataracts under the following bags, inhibiting growth in children, adrenal impairment, Cushing syndrome, osteoporosis and stomach ulcer .

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Medexa contraindicated in the following cases:

Systemic fungal infections.

Precautions when using

Do not recommend in pregnant women and breastfeeding mothers, unless it is necessary. Children born from mothers have used significant doses of corticosteroids during pregnancy should be carefully monitored and evaluated for signs of adrenal insufficiency.

While using corticosteroid therapy, patients should not vaccinate the bean vaccine or the other immunity especially with high doses due to the danger of neurological complications.

If corticosteroid is indicated in patients with tuberculosis or tuberculin reaction, careful monitoring should be monitored because the disease may recur.

The effect of corticosteroids may increase in patients with thyroid or cirrhosis.

Not recommended in patients with herpes simplex in the eye because it can cause cornea.

Using this drug can cover some signs of infection and new infections that can appear during the use of the drug.

Be cautious when used in patients with osteoporosis, new blood vessels, mental disorders, stomach ulcers and duodenum ulcers.

Acute adrenal insufficiency may occur when stopping the drug suddenly after a long time of treatment or when stressed.

Use cautiously in the elderly and children. Take the drug in the lowest doses in the shortest possible time.

The ability to drive and operate machinery

No.

Pregnancy and nursing mothers

Avoid use in pregnant women and nursing mothers.

Medicinal interaction

This drug is recommended simultaneously with food to minimize the effects of the gastric gastric.

Concentrated with nonsteroidal anti -inflammatory drugs or rheumatism can cause stomach bleeding.

If used simultaneously this drug with diabetes treatment, should reduce the recommendations.

Patients who have been vaccinated for seasons or immunodeficiency especially in high doses.

Concomitance Prednisolone and cyclosporine can lead to reduced intake of prednisolone in plasma and cyclosporine levels in plasma that may increase when treated simultaneously with methylprednisolone.

Corruption has been recorded in adults and children who are treating high doses of high doses and cyclosporine.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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