Medicine mixed with vigentin oral fluid 500mg/62.5mg pharbaco treatment for infections (12 packs x 2g)

Dosage form Box of 12 packs x 2g
Specifications Amoxicillin, clavulanic acid

Ingredient

Composition information	Content
Amoxicillin	500mg
Clavulanic Acid	62.5mg

Uses

Indication

vigentin is used for treatment in a short time of the following infections:

Upper respiratory infections: tonsillitis, sinusitis, otitis media have been treated with conventional antibiotics but does not help.

Lower respiratory infections by H.influenzae strains and Branhamella CatVrhalis produce beta - lactamase: acute and chronic bronchitis, pneumonia - bronchial.

Urinary - genital heavy infections by strains: E.coli, Klebsiella and Enerobacter produce beta - lactamase: cystitis, urethritis, pyelonephritis.

Skin and soft tissue infections: pimples, abscesses, wound infections.

Bone and joint infections: Bone inflammation.

Dental infections: Total abscess.

Other bacterial infections: abortion infections.

Pharmacokology

Amoxicillin is a semi -synthetic antibiotic belonging to the Beta - Lactam family that has a broad bactericidal spectrum for many Gram -positive and gram -negative bacteria due to the synthetic inhibition of bacterial cell walls. But because Amoxicillin is easily destroyed by beta - lactamase, therefore does not work for bacterial strains producing these enzymes (multiple En

Clavulanic acid due to the fermentation of Streptomyces Clavuligerus, which has a beta - lactam structure similar to penicillin, has the ability to inhibit beta - lactamase due to the majority of Gram -negative bacteria and staphylococcus. Especially, it has a strong inhibition effect of beta - lactamase transmitted via plasmid that resists penicillin and cephalosporins. Pseudomonas Aeruginosa, Proteus Morganii and Rettgeri, some entobacter strains and providentia resistant drugs, and methicillin resistant staphylococcus also resistant to this drug. Clavulanic acid itself has very weak antibacterial effects.

Clavulanic acid helps Amoxicillin not be destroyed by beta - lactamase, and expand the antibacterial spectrum of amoxicillin effectively for many common bacteria that have resisted amoxicillin, resistant penicillin and other cephalosporins.

It is possible to see Amoxicillin and Clavulanat as an antibacterial poison for pneumococcus, streptococcus beta beta, Staphylococcus (penicilin sensitive strains are not affected by penicillinase), Haemophilus Influenzae and Branhamella Catatrhalis, including strong products. lactamase. In short, the bactericidal spectrum of the drug includes:

Gram -positive bacteria:

Aerobic type: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes.

Anaerobic type: Clostridium species, peptococcus, peptostreptococcus.

Gram -negative bacteria:

Aerobic type: Haemophilus Influenzae, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitidis, Vibrio Cholerae, Pasteura Multocida.

Anaerobic type: Bacterioides including B.fragilis.

Dynamic pharmacokinetics

Amoxicillin and Clavulanat both absorb easy through oral. The concentration of these 2 substances in the serum is maximum after 1-2 hours of taking the drug. With a dose of 250 mg (or 500 mg), there will be 5 micrograms/ml (or 8 - 9 micrograms) amoxicillin and about 3 micrograms/ml of clavulanic acid in serum.

After 1 hour oral 20 mg/kg amoxicillin + 5mg/kg Clavulanic acid, there will be an average of 8.7 micrograms/ml of amoxicillin and 3.0 micrograms/ml of clavulanic acid in serum.

The absorption of the drug is not affected by food and it is best to take it right before meals.

AMOXICillin's oral bioactivity is 90% and of clavulanic acid is 75%.

Amoxicillin's waste time in serum is 1-2 hours and of Clavulanic Acid is about 1 hour. 55 - 70% amoxicillin and 30-40% Clavulanic acid are discharged in urine in the form of activity. Probenecid extends Amoxicillin's elimination time but does not affect the elimination of clavulanic acid.

Before taking Medicine mixed with vigentin oral fluid 500mg/62.5mg pharbaco treatment for infections (12 packs x 2g)

How to use

vigentin 500mg/62.5mg is taken at the beginning of eating to minimize the phenomenon of non -intolerance in the digestive tract.

Do not take the drug for more than 14 days without checking the treatment. Cut the package of drugs by lines and pour the powder into the cup.

Pour water into the package and then pour water from the package into the cup. Stir and drink now.

Dosage

Dosage is indicated as amoxicillin:

Adult dose: 500 mg/ time x 3 times/ 24 hours.

Child dosage: Children from 40 kg of weight or more: Take adult dose.

Children under 40 kg of weight: Normal dose: 80 mg amoxicillin/kg weight/day, divided into 3 times/24 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In case the kidney function decreases and the blood -brain barrier, the injection will cause symptoms of poisoning. However, general reactions occur depending on the hypersensitivity of each individual. The risk is definitely hyperkalemia when taking a very high dose because clavulanic acid is used in the form of potassium salt. You can use the method of hemolysis so that the drug is from circulation.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

With normal doses, unwanted effects can show over 5% of patients:

Common

diarrhea, foreign rash, itching.

Less

Itching, erythema, rash.

Rare

Anaphylaxis reaction, Phuincke.

When encountering side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Vigentin drugs contraindicated in the following cases:

allergies to antibiotics belonging to the beta - lactamin group.

Single leukemia caused by infection.

Patients with a history of jaundice, liver dysfunction due to the use of amoxicillin and clavulanate or penicillin because clavulanic acid causes increased cholestatic risk in the liver.

Be cautious when using

for patients with manifestation of liver dysfunction: Signs and symptoms of cholestasis jaundice occur rarely when taking the drug but may be severe. However, these symptoms are often recovered and will end after 6 weeks of stopping treatment.

For people with average or severe renal impairment, attention should be paid to the dosage.

For patients with a history of hypersensitivity to penicillin may have severe reactions or death. When used with patients using amoxicillin, redness with lymphadenopathy.

Take the drug that sometimes develops anti -drug bacteria.

The ability to drive and operate machinery

There is no evidence of the effect of the drug on the ability to drive, operate machinery.

Pregnancy

Experimental research on the reproductive process of mice proved when using oral preparations and injections did not cause deformities. However, because there is little experience in using preparations for pregnant women, it is necessary to avoid using drugs in pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

The period of breastfeeding

during breastfeeding may be used. The drug is not harmful to breastfed children unless there is a risk of sensitivity due to a very small amount of medicine in milk.

Interactive drug

The drug can cause prolonged melting and blood clotting time. Therefore, it is necessary to be careful for patients who are being treated with anticoagulants.

As other broad -spectrum antibiotics, vigentin reduces the effectiveness of oral contraceptives, so it is necessary to notice to the patient in advance.

Storage

Where dry, less than 30 ° C.

Other drugs

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