Medicine Repraz 20mg Medley Treatment of peptic ulcer (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Rabeprazole

Ingredient

Composition information	Content
Rabeprazole	20mg

Uses

Indications

Repoz - 20 drugs are indicated in the following cases:

Acute duodenal ulcerative treatment, acute gastric ulcer, gastroesophageal reflux syndrome - Protein with or without esophagitis, ulcers or scratches. Learning

Rabeprazole is a benzimidazole derivative, which inhibits proton pump. Rabeprazole is a new generation of proton pump inhibitors (PPI) in the benzimidazole nucleus, inhibiting stomach acid secretions due to the inactivated enzyme H+/K+–atpase in the stomach cells.

Rabeprazole has the effect of inhibiting basic gastric secretion and in a state of stimulation, no acetylcholine resistant or histamine H2 receptor antagonist, by inhibiting H+/K+ -–atpase enzyme in the cell wall of the gastric mucosa. This enzyme is considered an acid, hydrogen or proton pump in the cell so Rabeprazole is considered a proton pump inhibitor.

rabeprazole attaches to the enzyme H+/K+–atpase, blocking the final stage of gastric secretion. In the stomach wall cell, Rabeprazole is protonized and converted into activated sulfenamide, then attached to the cysteine of the proton pump as this enzyme inactivation.

pharmacokinetic

absorption

Rabeprazole is absorbed very quickly and the peak concentration in plasma reaches 3.5 hours after taking the drug.

Oral bioavailability is about 52% for tablets soluble in the intestine due to metabolized through the first circulatory and unchanged when the dose is one -time or the dose is repeated.

Distribution

Rabeprazole attaches nearly 97% to plasma proteins.

Metabolism

In vitro, Rabeprazole metabolized in the liver by the ISOENZE Cytochrome P450 (CYP2C19 and CYP3A4) into thioeters, thioeters of carboxylic acid, sulfon and desmethylioeter.

In test plasma concentrations, Rabeprazole does not touch or inhibit CYP3A4.

Elimination

Metabolic derivatives are excreted mainly through urine (nearly 90%), the rest is deducted through feces.

Rabeprazole's semi -waste time in plasma is about 1 hour, an increase of 2-3 times in patients with hepatic impairment, 1.6 times in CYP219 enzymes that are slowly metabolized and increased by 30% in the elderly.

Before taking Medicine Repraz 20mg Medley Treatment of peptic ulcer (3 blisters x 10 tablets)

How to use

Medicine Repraz - 20 Used oral. Take intact tablets, do not chew, crush or break the pill.

Dosage

In case of acute duodenal ulcer: Take 20 mg/day, 1 time in the morning. Drink for 4 weeks if the ulcer is not complete.

Cases of benign stomach ulcers: Take 20 mg/day, 1 time in the morning, for 6 weeks. Continue to drink 6 weeks if the ulcer is not completely immediately.

Gastroesophageal reflux syndrome - ulcerative or scratch symptoms: Take 20 mg x 1 time/day x 4 - 8 weeks. Gastroesophageal reflux disease must be treated for a long time. For maintenance treatment, the daily dose recommendes 10 - 20 mg x 1 time/day depends on the response of the patient.

Treatment of symptoms of gastroesophageal reflux disease - non -esophagitis: recommended dose 10 mg/day/day until 4 weeks, then 10 mg/time/day when needed. If the symptoms are not controlled for 4 weeks, patients need to be re -examined.

Zollinger - Ellison syndrome: The starting dose of 60 mg/time/day. The dose may increase up to 120 mg/day, divided 2 times depending on the need for each patient. The dose can be indicated 1 time/day up to 100 mg. The course lasts until the clinical symptoms are over.

Autodor ulcer and benign stomach ulcer combined with H.pylori infection: recommend the following combination of drugs within 7 days: Rabeprazole 200 mg/time x 2 times/day + Clarithromycin 500 mg/time x 2 times/day + Amoxicillin 1 g/time x 2 times/day. The drug is taken in the morning and evening.

Patients with liver failure, kidney failure: No dose adjustment.

Children: Do not use it because there is no experience.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

There is no specific antidote. Because rabeprazole is very strong with protein, it cannot be eliminated by the method of fertilizer.

In case of an overdose, it is necessary to treat symptoms and support treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using a review drug, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: headache, dizziness, insomnia.

Respiratory: cough, sore throat, rhinitis.

digestive: diarrhea, abdominal pain, flatulence, dry mouth, nausea, vomiting, constipation. Systemic: weakness. Skin: rashes.

Muscle muscle: back pain.

Infections, influenza symptoms.

Uncommon, 1/1000

Neurological: restlessness, drowsiness.

digestive: indigestion, dry mouth, belching. skin: itching, pink.

Muscle muscle: muscle pain, cramps, joint pain.

urinary tract infections. liver: Increase liver enzymes. Systemic: chills, fever.

Rare, 1/10000

Blood: Multi -neutral leukocytes, leukocytes, platelets.

Cardiovascular: Hypertension. digestive: Anorexia, gastritis, tooth inflammation, taste disorders, weight gain. liver: hepatitis, jaundice, liver disease. nerve: depression. Eye: visual disorders.

Skin: itching, sweating, sweating reaction.

kidney: interstitial nephritis.

Very rare, ADR

Diverse immunity: Stevens - Johnson syndrome, poisoned epidermal necrosis.

Not determined frequency

Metabolism: hypoglycemia.

circuit: peripheral edema.

Genital: Big breasts in men.

Instructions on how to handle ADR

The ADR is usually light and out when stopping the drug. Immediately notify the doctor or pharmacist the harmful reactions encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Repraz-20 contraindications in the following cases:

Sensitive to Rabeprazole, the derivatives of benzimidazole (for example: Esomeprazole, Lansoprazole, Omeprazole, Pantoprazole) and any ingredients of the drug.

Pregnant and lactating women.

Caution when using

Response treatment for Rabeprazole therapy does not exclude the existing stomach or esophagus tumors. Therefore, it is necessary to eliminate the possibility of a malignant tumor before treatment with Rabeprazole. Treatment lasts more than 1 year with Rabeprazole need periodic monitoring.

Be cautious when using Rabeprazole because of the risk of hypersensitivity reactions to other proton pump inhibitors or benzimidazole derivatives when used instead of.

Do not use rabeprazole for children because they have no experience.

There have been reports on hematopoietic disorders such as thrombocytopenia and neutropenia. Most cases do not find the disease but these disorders are not serious and will end when stopping using Rabeprazole.

In clinical trials and after use, there are abnormal reports on liver enzymes. If there is no other cause, these enzyme disorders are not serious and will stop using rabeprazole. Be cautious when indicating Rabeprazole for the first time patients with severe liver failure.

Proton pump inhibitors may increase the risk of gastrointestinal infections with Salmonella, Campylobacter and Clostridioides Difficile.

Do not be indicated in combination with Rabeprazole Sodium with Atazanavir.

Do not use Rapeprazole for patients with Galact

The ability to drive and operate machinery

rabeprazole may affect the ability to drive or control machines. It is recommended not to drive or control machines when using Rabeprazole.

Pregnancy

Contraindicated for pregnant women. There is no research data on Rabeprazole's safety for pregnant women.

Breastfeeding period

Contraindications to mothers during breastfeeding. It is unknown whether Rabeprazole is in breast milk or not. No research has been conducted in breastfeeding women.

Drug interaction

combine Rabeprazole with ketoconazole or digoxin reducing 33% ketoconazole and an increase of 22% of the bottom content of digoxin in healthy people. Therefore, each patient needs to be monitored to determine if there is a need to adjust the dosage when taking these drugs with rabeprazole.

Avoid simultaneous use of rabeprazole with erlotinib, nelfinavir, delavirdine, posaconazole.

SHOULD RAPEPRAZALE Use 40mg/day with Atazanavir 300mg/Ritonavir 100mg sharply reduces Atazanavir concentration due to the absorption of Atazanavir depends on pH.

Rabeprazole may reduce the concentration/effect of Atazanavir, Clopidogrel, Dabigatran, Ethilat, Dasatinib, Erlotinib, Indinavir, Iron Salt, Itraconazole, Ketoconazole, Mesalamine, Mycophenolate, Nelfinavir.

rabeprazole may increase the concentration/effect of drugs that are CYP2C19, CYP2C8 (high risk level), Methotrexate, Saquinavir, Voriconazole.

Storage

Store at a temperature not exceeding 30ºC, a cool dry place. Leave the medicine out of reach of children.

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