Mediplantex Supbotic Medicine Treatment of irritable bowel syndrome (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Trimebutin

Ingredient

Composition information	Content
Trimebutin	200mg

Uses

Indications

Supbotic 200mg drugs are indicated in the following cases:

Symptoms of irritable bowel syndrome (IBS), digestive dysfunction, abdominal pain, abdominal distention, diarrhea or constipation.

Treatment of intestinal paralysis after abdominal surgery, reducing pyloric spasm/colon colonoscopy.

Pharmacy

trimebutine is a gastrointestinal peristalsis regulator. It promotes intestinal motility by activating phase waves created by moving movement complex, it also inhibits peristalsis when the previous stimulation occurs.

Trimebutine is an non -competitive anti -contracting agent that has serotonin resistance and has a moderate affinity with the opiate receptor, reducing abnormalities but does not change the normal motility of the gastrointestinal tract.

pharmacokinetic

absorption

Human metabolic studies show that C14 - Trimebutin Maleat or its free base form is quickly absorbed after drinking. The peak concentration of the active ingredient in plasma is achieved within 1 hour. The time to achieve the peak concentration in plasma after taking a single dose of 200mg trimebutine is 0.80 hours.

Distribution

trimebutine is more likely to be accumulated in the stomach and intestinal wall at the highest concentration. Protein bonds are at least for 5% in vivo and in vitro with serum albumin.

Metabolism

Trimebutine undergo the first metabolism in the liver. Nortrimebutine or N-Monodesmethyltrimebutine, which is the main metabolite that retains pharmacological activity on the colon. This metabolic substance can undergo the second n-demethyl process to form n-didesmethyltrimebutine. Trimebutine is also susceptible to sulphate or associated with glucuronic acid.

Elimination

The excretion is the main urine while a small amount of release active ingredient is found in feces. Half of the plasma of the trimebutine is short but the half -life of the release active ingredient is approximately 10 - 12 hours.

Before taking Mediplantex Supbotic Medicine Treatment of irritable bowel syndrome (6 blisters x 10 tablets)

How to use

Take oral use. Can be used in the same food or not.

Dosage

Adults

Use 1 tablet x 3 times/day.

Children

This drug is not used for children under 12 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, if the overdose occurs after drinking, the stomach should be performed and symptomatic treatment.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the 200mg Supbotic drug, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: dry mouth, bad breath, diarrhea, indigestion, epigastric pain, nausea and constipation.

Central nervous system: drowsiness, fatigue, dizziness, hot feeling, cold and headache.

Uncommon, 1/1000

Allergic reaction: rash.

Other: Menstrual problems, big chest pain, anxiety, urine retention and mild deaf.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Supbotic drug 200mg contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug.

Caution when using

Disregard for patients with non -tolerance Galatose and Lapp Lactase deficiency or poor absorption syndrome Glucose or Galactose (rare genetic disease).

The ability to drive and operate machinery

The drug can cause sleepy, dizzy side effects that affect the ability to drive and operate machinery.

Pregnancy

Pregnant women should only take the drug when prescribed by a doctor. If you find pregnancy while taking the medication, notify your doctor to decide whether to continue taking the medication or not.

Breastfeeding period

Do not know if Trimebutine will go into breast milk. If you are breastfeeding and using this medication, it can affect babies. Should only be used for breastfeeding women when really necessary.

Drug interaction

Animal studies have shown that trimebutin increases the existence time of Curarization D-Tubocurarin when treated with cua. No other drug interactions are observed or reported in clinical trials.

Storage

Store below 30 degrees C.

Other drugs

Disclaimer

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