Medisamin 250mg Mediplantex Treatment of bleeding (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Tranexamic acid

Ingredient

Composition information	Content
Tranexamic acid	250mg

Uses

indication

Medisamin 250 mg is indicated in the following cases:

Treatment in a short time of bleeding or at risk of bleeding in people with increased destruction of fibrin or fibrinogen.

Local Fibrin destruction treatment occurs in the following cases:

Prostate and bladder removal surgery. Learning

tranexamic acid is a synthetic conductor of lysin amino acid that has anti -fibrin elimination effect, inhibiting fibrin decomposition in blood clots. The main mechanism of action of Tranexamic acid is to prevent plasminogen and plasmin attached to fibrin, thus preventing the solubility of the hemostatic button; Plasmin's direct inhibitor only occurs only at a low level. Fibrin's natural chemistry inhibitors, stabilizing blood clots.

The essential concentration of tranexamic acid in plasma is 5 - 10 micrograms/ml to inhibit fibrin elimination. In vitro: Tranexamic acid works similar to aminocaproic acid but 10 times stronger, Tranexamic acid at a concentration of 1 mg/ml does not cause platelets to collect. At a concentration of up to 10 mg/1 ml of blood, it has not affected the number of platelets, blood clotting time or blood clotting factors in whole blood or blood citrate in normal people. But Tranexamic acid at concentrations of 10 mg and 1 mg/1 ml of blood prolonged the thrombin time.

Pharmacokinetics

absorption

Tranexamic Acid is absorbed from the digestive tract, reaching the highest concentration in plasma after about 3 hours (intramuscularly 1 hour, intravenously 3 minutes). Birth of drugs is about 30-50%.

Distribution

The drug is widely distributed in the body, very little to the plasma protein (3%). The distribution of adults is 9 - 12 liters. The drug passes the placenta and breast milk (1 % compared to the serum), into the cerebrospinal fluid (10 % compared to plasma). The drug is quickly distributed into joint fluid and synovial membrane in joint fluid, the concentration of the drug is similar to the serum.

Elimination

Half lifetime eliminated in plasma for about 2 hours. After intravenous injection, 95% of the drug dose excreted in the form of unchanged urine, but after drinking, this ratio is only 39%.

Before taking Medisamin 250mg Mediplantex Treatment of bleeding (10 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Adults:

Local fibrin pepper: recommended dose is 15 - 25 mg/ kg (about 1.0 - 1.5 g), 2-3 times a day. Dosage for specific indications as follows:

Prostate removal surgery: Preventive and treating bleeding in high -risk patients should start before or after surgery by the form of tranexamic acid injection; Then drink 1.0 g, 3-4 times a day until there is no urination.

Menstrual menstrual dosage: The dosage recommends 1.0 g, 3 times a day, up to 4 days. If the menstrual period is heavy, the dose may increase. The maximum total dose per day is 4.0 g. Treatment should start at the beginning of menstruation.

Nosebleeds: When recurrent bleeding has been predicted, taken 1.0 g each time, 3 times a day in 7 days.

Cervical surgery: Take 1.5 g each time, 3 times a day.

Bleeding after eye injury: Take 1.0 - 1.5 g each time, 3 times a day. Dosage based on weight of 25 mg/ kg, 3 times a day.

Tips for tooth extraction for people with bleeding disease: Take 1.0 - 1.5 g every 8 hours. Dosage based on weight 25 mg/ kg.

Genetic angioedema: For patients diagnosed at the stage of onset of the disease, the treatment is 1.0 - 1.5 g each orchid, 2-3 times a day in a few days. Other cases need continuous treatment with the above dose.

Children:

Normal dose takes 20 mg/ kg/ day. However, it is necessary to consider the effectiveness and safety when taking the drug.

Elderly:

Do not reduce the dose unless there is evidence of renal failure.

People with kidney failure:

Adjust the dose and distance based on serum creatinine levels for patients with mild and moderate renal impairment:

serum creatinine concentration (micromol/liter) Dosage Frequency

120 - 249 Date

250 - 500 15 mg/kg 1 time/day Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? The overdose symptoms may be: nausea, vomiting, symptoms and/or hypotension.

There is no special measure to treat Tranexamic acid poisoning. If the poisoning is overdosed, causing vomiting, gastric lavage and active carbon. In both cases of oral and infusion, it is advisable to maintain additional fluid to promote the excretion of the kidneys and use symptomatic treatments and support treatment.

What to do when forgetting 1 dose? Do not use double dose to compensate for the forgotten dose.

Side Effects

When using Medisamin 250 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, diarrhea or abdominal pain.

Uncommon, 1/1000

Cardiovascular: Hypotension, blood tolerance (deep vein thrombosis in the legs, pulmonary embolism, thrombosis in the meningide, aorta, retinal artery, thrombosis in the artery in the skull).

Central nerve: ischemic is local and cerebral infarction (when used to treat subarachnom bleeding), headache, brain effusion, dizziness.

Hematology: thrombocytopenia, coagulation disorders, abnormal bleeding time.

Surgery: Colorful visual abnormalities, visual reduction, central vein retinopathy.

urinary tract: acute kidney necrosis in people with diseased bleeding A. Renal failure combined with rare acute renal necrosis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Medisamin 250 mg contraindicated in the following cases:

Hypersensitivity to tranexamic acid or any ingredients of preparations.

There is a history of turbulence or thrombosis ( myocardial infarction , stroke ...).

Bleeding subarachia, colorful visual disorders (due to non -monitoring the toxicity of the drug).

Severe kidney failure.

Be cautious when using

adjust the dose in people with renal failure. Precautions when used in people with cardiovascular disease, kidney disease, cerebrovascular disease or surgery to remove prostate through the urethra.

Patients using Tranexamic acid can inhibit the breakdown of blood clots that exist in the pulse. Blood clots in the kidney system can lead to obstruction in the kidneys, so be cautious in bleeding people (avoid use if there is a risk of ureter obstruction).

Pagoda bleeding is not treated with fibrin anti -elimination drugs unless the disease is mainly due to fibrin disorders. In some appropriate cases, Tranexamic acid can be used later, but must be carefully monitored and used anticoagulants.

Be cautious in uneven menstrual periods, pregnant women.

Checking liver and visual function regularly when long -term treatment.

Not simultaneously with the complex of IX factors or coagulants due to increased risk of thrombosis.

Use Tranexamic acid after subarachnom bleeding can increase the proportion of ischemic complications in the brain.

The ability to drive and operate machinery

There has been no research on the effect of the drug on the ability to drive, operate machinery, people working on high and other cases.

pregnancy

The drug can be given the placenta. There is no evidence of teratogenic effects on experimental animals. Documents about using tranexamic acid for pregnant women are very few, so only drugs only during pregnancy when the benefits are greatly exceeding the risk of drugs that may cause.

breastfeeding period

tranexamic acid secreted into breast milk but the concentration is only 1% in the mother's blood. Precautions when taking medicine in breastfeeding women.

Interactive drugs

Unbeature Tranexamic Acid with estrogen because it can cause more thrombosis.

Be cautious when using Tranexamic Acid with other hemostasis.

The anti -fibrin effect of the drug is antagonistic by medications that soluble thrombosis.

Simultaneous use of tranexamic acid with oral tretinoin can cause thrombosis in microchips.

Storage

In a dry place, avoid light, temperature below 30 ° C.

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