Medisamin 500mg Mediplantex treatment for bleeding in bleeding, menstrual bleeding (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Tranexamic acid

Ingredient

Composition information	Content
Tranexamic acid	500mg

Uses

Indications

Medisamin 500mg medicine is indicated in the following cases:

Treatment and prevention of bleeding in combination with excessive fibrin pepper: during and after tooth extraction in people with bleeding, prostate removal surgery, cervical removal, bladder surgery. Use in a short time (2 - 8 days). Anti -fibrin effectively, inhibiting fibrin decomposition in blood clots. The main mechanism of action of Tranexamic acid is to prevent plasminogen and plasmin attached to fibrin, thus preventing the solubility of the hemostatic button, directly inhibiting the dissolution of plasmin only occurs at a low level. The drug inhibits the natural chemistry of fibrin, stabilizing blood clots. The essential concentration of tranexamic acid in plasma is 5 - 10 micrograms/ml to inhibit fibrin elimination.

pharmacokinetics

tranexamic acid is absorbed from the digestive tract, reaching the highest concentration in plasma after about 3 hours. The bioavailability of the drug is about 30-50%. The drug is widely distributed in the body, attaching very little to plasma proteins (3%).

The drug through the placenta and the breast milk (1% compared to the serum), into the cerebrospinal fluid (10% compared to plasma). The drug is quickly distributed into joint fluid and synovial membrane in joint fluid. The sale time of the drug is about 2 hours.

Before taking Medisamin 500mg Mediplantex treatment for bleeding in bleeding, menstrual bleeding (10 blisters x 10 tablets)

How to use

Take the whole tablet Medisamin 500mg with a glass of water.

Patients can only use Medisamin 500mg when prescribed by a doctor.

Dosage

Adults

Treatment in a short time of excessive fibrin bleeding: each time taking 2-3 tablets (or 15 - 25mg/kg), 2-4 times a day.

Dental surgery for people with bleeding diseases: drinking 25mg/kg each time, 3-4 times a day, starting a day before surgery, within 2-8 days.

Menstrual menstrual: (Start at the beginning of menstruation), take 2 capsules each time, 3 times a day, up to 4 days. The maximum dose per day 4.0 grams.

Genetic angioedema: Take 2-3 capsules at 2-3 tablets, 2-3 times a day.

Nasal bleeding: Take 2 capsules each time, 3 times a day in 7 days.

Children

Normally each drink 25mg/kg, 2-3 times a day, depending on indications.

Renal failure

Adjust the dose and distance based on serum creatinine (SCC) or due to creatinine clearance (CLCR).

Adjust according to serum creatinine levels:

SCC index 120 - 250 micromol/liter: Take 15mg/kg, 2 times a day. Used above is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

There is no special measure to treat Tranexamic acid poisoning. If an overdose is poisoned, it can cause vomiting, gastric lavage, and active carbon. In both cases of toxicity due to oral or infusion, it is recommended to maintain additional fluids to promote the excretion of the kidneys and use symptomatic treatments and support treatment.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Medisamin 500mg , you may experience unwanted effects (ADR).
The unwanted effect is often rare and mainly limited to nausea, diarrhea or abdominal pain. These symptoms are common when taking high doses, reduced when reducing the dose. . Mind.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Medisamin 500mg contraindicated in the following cases:

Hypersensitivity to tranexamic acid or any component of the preparation.

severe renal failure.

Precautions when using

must be cautious when taking this medication for the following patients:

Renal impairment: Need to adjust the dose for people with kidney failure due to the risk of accumulation of tranexamic acid. Blood clots in the kidney system can lead to congestion in the kidneys. Be cautious in bleeding people (avoid use if there is a risk of ureter obstruction). In some appropriate cases, Tranexamic acid can be used later but must be carefully monitored and used anticoagulant drugs. tranexamic after subarachnom bleeding can increase complications of ischemia in the brain.

The ability to drive and operate machinery

Use Medisamin 500mg cautious with the driver and operating machinery.

Pregnancy and lactation

Pregnancy

The drug can pass the placenta. There has been notice of teratogenic effects on experimental animals. Information about the use of tranexamic acid for pregnant women is very small, so it should only be used during pregnancy when the benefits are over the risk of drugs that may cause.

Breastfeeding period

Tranexamic acid is secreted into breast milk but the concentration is only 1% in the mother's blood. Precautions when taking medicine in breastfeeding women.

Drug interaction

should not simultaneously use Tranexamic acid with estrogen because it can cause more thrombosis.

Be cautious when using Tranexamic Acid with other hemostasis.

The anti -fibrin effect of the drug is antagonistic by medications that soluble thrombosis.

Simultaneous use of tranexamic acid with tretinoin oral can cause thrombosis in microchips.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children.

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