Meditrol 0.25mcg Mega treatment for osteoporosis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Calcitriol

Ingredient

Composition information	Content
Calcitriol	0.25mcg

Uses

indications

Meditrol drugs are indicated in the following cases:

Treatment of osteoporosis in women during menopause, bone dysplasia in patients with chronic renal impairment, especially for patients with dialysis, reduces the ability of the parathyroid and rickets.

Pharmacokological

Calcitriol is one of the most important metabolites of vitamin D3. Usually it is made up of precursors in the kidneys, 25 - hydroxycholecalciferol (25 - HCC).

Calcitriol produces normal physiological production of about 0.5 - 1mcg/day and slightly higher in the period of bone synthesis (growth or pregnancy). Calcitriol stimulates the absorption of calcium in the intestine and regulates the soaked in bone.

The pharmacological effect of the Calcitriol solo doses lasts about 3-5 days. The main role of calcitriol in regulating internal balance of calcium in the bone, including stimulating the activity of the cell, this is the basic pharmacological effect for the effectiveness of the treatment of osteoporosis.

In patients with severe renal failure, the synthesis of endogenous calciol is limited, not even. This is the main cause of the progression of bone disorder due to kidney.

In patients with renal bone dysplasia, reducing the absorption of calcium in the intestine, lowering blood calcium, increasing blood alkaline phosphatase and increasing the level of parathyroid hormone back to normal limits when using oral calcitriol. It has the effect of reducing muscle pain, bone pain and hypopped from tissue due to fibrosis and other defects due to mineral infection.

In patients with undergarctic undergar hyperpointing, spontaneous parathyroidism and fake parathyroidism. Blood calcium hypoclower and clinical manifestations decreased when treated with calcitriol.

In patients with rickets associated with vitamin D, serum calciol levels are very low or not available. Because the amount of endogenous calcitriol in the kidney is not enough, Calcitriol treatment is considered an alternative treatment.

In patients with rickets resistant to vitamin D and lower blood phosphate, serum calciol levels are often low. Calcitriol treatment reduces the excretion of phosphate through the ureter and coordinates with phosphate treatments will help bones grow normally.

In patients with other rickets such as rickets caused by newborn hepatitis, dysplasia, cystin dysplasia, calcium deficiency and vitamin D due to diet, Calcitriol therapy is also effective.

pharmacokinetic

absorption

Calcitriol is quickly absorbed through the gastrointestinal tract (intestine). The peak concentration in plasma is achieved after the single dose is 0.25 - 1mcg for 3 - 6 hours. When used evenly, Calcitriol reaches a stable concentration within 7 days, depending on the dose.

Distribution

In Calcitriol blood and other metabolites of vitamin D attached to plasma proteins. Calcitriol passes through the placenta and excluded in breast milk.

Metabolism

Some metabolites of Calcitriol have been identified, each with a different activity of vitamin D such as 1 alpha, 25 - dihydroxy - 24 - Oxo - Cholecalciferol, 1 alpha, 23 - 25 - Trihydroxy - 24 - Oxo - Cholecalciferol, 1 Alpha, 24R, 25 - Trihydroxolecerol, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha, 1 alpha 25R - dihydroxycholeciferol - 26, 23s - lactone, 1 alpha, 25s, 26 - dihydroxycholeciferol, 1 alpha - hydroxy - 23 - Carboxy - 24, 25, 26, 27 - Tetranorcholeciferol.

Elimination

Serum waste sale time in serum is 3 - 6 hours. However, the pharmacological effect of the single dose lasts 3-5 days. Calcitriol is excreted through bile and depends on the gut.

Before taking Meditrol 0.25mcg Mega treatment for osteoporosis (3 blisters x 10 tablets)

How to use

Take oral use. Use medication as directed by the doctor.

Dosage

Standard dose

Calcitriol's optimal daily dose should be carefully identified for patients depending on the ratio of calcium in the blood. Calcitriol should be started at the lowest possible doses and should not increase the dose of the drug without testing tests about the level of calcium in the blood.

For patients with osteoporosis after menopause

The recommended dose is 0.25mcg, twice a day. Need to monitor blood calcium and creatinine levels after 4 weeks, after 3 months, after 6 months and periodically every 6 months later.

For patients with renal dysplasia (patients after hemorrhage)

The daily ratage dose is 0.25mcg. In patients with normal blood calcium levels or only slightly reduced, the dose of 0.25mcg per day is enough. If the drug responds badly through biochemical parameters and clinical manifestations observed within 2 to 4 weeks, the dose may increase by 0.25mcg per day within 2 to 4 weeks periodically.

During this time, it is necessary to monitor blood calcium at least twice a week. Most patients respond to 0.5 to 1mcg a day.

For patients with hypoglycemia and rickets

The starting dose is 0.25mcg a day in the morning. If the drug responds badly through biochemical parameters and clinical manifestations observed within 2 to 4 weeks, the dose may increase by 0.25mcg per day within 2 to 4 weeks periodically.

During this time, it is necessary to monitor blood calcium at least twice a week. For patients suffering from parathyroidal reduction, they are often absorbed in poorly absorbed, so it may be necessary to take a higher Calcitriol dose.

For the elderly

There is no specific dose used for the elderly. The general advice is to monitor blood calcium and creatinine levels.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? High calcium concentration in the epidemic reflects with hypercalcemia.

Signs of acute vitamin D: anorexia, headache, vomiting, constipation.

Signs of chronic poisoning: Dehydration (weakness, weight loss), sensory disorders, may have a fever accompanied by thirst, multi -urinary, dehydration, insensitivity, growth and urinary tract infection. Chronic poisoning will cause secondary hypercalcemia with calcification of the kidney, heart muscle, lung and pancreatic.

Overdose treatments include: Stomach lavage immediately or causing vomiting to avoid adding more drugs to the stomach. Use paraffin oil to increase the elimination of drugs through feces. Conduct multiple blood calcium tests. If blood calcium concentration is still high, can use phosphate and corticosteroids, and use appropriate measures to increase the urethra.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Meditrol, you may experience unwanted effects (ADR).

Because Calcitriol has the activity of Vitamin D, the side effects occur similarly to the overdose of vitamin D, such as blood hypercalcemia syndrome or calcium poisoning (depending on the degree and duration of hypercalcemia). The signs of acute hypercalcemia syndrome are anorexia, headache, vomiting and constipation. Chronic syndrome may include nourishment, sensory disorders, fever and thirst, urination, apathy, restraining the growth and urinary tract infections.

At the same time, with hyperactical hyperacture and hyperglycemia at> 6mg/100ml or> 1.9mmol/l, the calcification of soft tissues may appear, can see that when shooting X -rays.

Due to Calcitriol's short biometical half -life time, through a pharmacological investigation, it has shown that the normalization of blood calcium within a few days after stopping or reducing the dose is much faster than the treatment of vitamin D3.

When the symptoms appear, it is advisable to stop using and refer to the doctor. Notify the doctor the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Meditrol drugs contraindicated in the following cases:

Hypercalcemia.

Patients who are taking vitamin D products.

Precautions when used

There is a close correlation between Calcitriol treatment for the development of hypercalcemia. It is advisable to advise patients and family members to thoroughly respect the diet and guide them on how to identify signs of hypercalcemia.

For normal kidney function patients, chronic hypercalcemia may be associated with increased creatinine in serum.

Patients who have to lie motionless such as patients who have just undergone surgery are special people at risk of hypercalcemia.

Calcitriol increases the inorganic phosphate level in serum. This is essential for patients with reduced blood phosphate, but should be very careful for patients with kidney function impaired due to kidneys.

Patients with vitamin D resistant (patients with family blood phosphate) when treated with calcitriol should continue to use preparations containing phosphate. However, attention should be paid to the ability to increase phosphate absorption from the digestive tract of Calcitriol and it is because of this effect that may need to adjust the amount of additional phosphate.

If patients have the conversion of Ergocalciferol (Vitamin D2) to Calcitriol, it will take about a few months for the concentration of Ergocalciferol in the blood to return to normal.

Patients with normal renal function should avoid water shortage or dehydration during the use of Calcitriol. Should maintain the amount of water put into the body at a normal level.

Hypersensitivity reactions to drugs may occur in some patient meetings with sensitive atopic.

The ability to drive and operate machinery

There has been no full study of adversely affecting the ability to drive and operate machinery.

Pregnancy

Research on toxicity on the reproductive system of animals did not produce clear evidence and no studies control the effects of external calciol on pregnant women and fetal development. Therefore, Calcitriol should only be used in case of careful consideration to keep the benefits of the drug and risk the risk may occur for the fetus.

Breastfeeding period

It is necessary to admit that external calcitriol is exempted into breast milk. To avoid harmful harmful effects on children, mothers have to stop breastfeeding when using Calcitriol.

Medicinal interaction

drugs containing magnesium (antacid) may be the cause of hyperglycemia so do not use them during treatment with Calcitriol in chronic dialysis patients. Calcitriol also affects the transformation of phosphate in the small intestine, kidney and bone, so the dose of phosphate replacement agents needs to be adjusted to meet the phosphate level in the bar (normal concentration is 2.5mg/100ml or 0.6 - 1.6mmol/l).

Because Calcitriol is one of the most important metabolic products of vitamin D3, it is necessary to suspend all the preparations of vitamin D and its derivatives during the Calcitriol treatment period to avoid possible side effects and avoid hypercalcemia.

Concentrated use with thiazide diuretics increases the risk of hypercalcemia. Calcitriol dose needs to be carefully prescribed in patients treated with Digitalis cardiac aids because of hyperactical hyperacture in such patients may cause arrhythmia.

Storage

Store in a dry place of temperatures below 30 ° C. Avoid direct contact with heat.

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