Medlon 16 DHG Pharma anti -inflammatory, immunosuppressive in arthritis, lupus erythematosus (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Methylprednisolone

Ingredient

Composition information	Content
Methylprednisolone	16mg

Uses

Indications

Medlon 16 drugs are indicated in the following cases:

Anti -inflammatory and immunodeficiency in: rheumatoid arthritis, systemic lupus erythematosus, some forms of vasculitis, temporal arteritis and inflammation around the artery, sarcoid disease, bronchial asthma, chronic ulcerative, hemolytic anemia, granular leukemia, and severe allergens including anaphylaxis, in cancer treatment such as acute leukemia, lymphoma, lymphoma.

Treatment of nephropathy syndrome. Due to methylation Prednisolon, corticosteroid effect on salt metabolism has been excluded, so there is little risk of salt, water and edema. The anti -inflammatory effect of methylprednisolon increases by 20% compared to the effect of Prednisolon, 4mg of methylprednisolon, which is valid as 20mg of hydrocortison.

pharmacokinetics

bioavailability is about 80%, plasma concentration reaches a maximum of 1-2 hours after taking the drug.

Selling time is about 3 hours. Methylprednisolon is metabolized through the liver, the metabolites are excreted through the urine.

Before taking Medlon 16 DHG Pharma anti -inflammatory, immunosuppressive in arthritis, lupus erythematosus (3 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Determine the dose for individuals.

The starting dose is 6 - 40mg of methylprednisolon per day. The necessary dose to maintain the desired treatment is lower than the dose needed to achieve the initial effect and must determine the lowest dose that can achieve the necessary effect by reducing the dose gradually step by step until the signs or symptoms increase.

When you need to use big doses for a long time, apply medication therapy the day after control of the process of the disease, there will be less unwanted effects because of the recovery time between each dose.

In a daily -way therapy, using a single dose of methylprednisolon every 2 days, in the morning in the span of natural secretion glucocorticoid.

Treatment of acute asthma attacks

Use 32 - 48mg/day for 5 days, then additional treatment can be treated at a lower dose in a week. When from acute attacks, the drug is gradually reduced.

Rheumatoid arthritis.

Use 16 - 32mg/day, then gradually decrease quickly.

Chronic ulcerative acute ulcerative

Use 8 - 24mg/day.

Nephropathy syndrome

Start 0.8 - 1.6mg/kg/day for 6 weeks, then gradually reduce the dose for 6 - 8 weeks.

Hemorrhagic anemia due to immunity

Use 64mg/day, at least 6-8 weeks.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? It is necessary to consider suspending or stopping the drug.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Medlon 16, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Insomnia, nervousness is easily agitated.

Increase deliciousness, indigestion.

Hairy. diabetes. joint pain.

cataracts, glaucoma.

Nosebleeds.

Uncommon, 1/1000

Dizziness.

seizures, mental disorders, fake tumors in the brain, headache, mood change, delirium, hallucinations, refreshment, edema, hypertension.

acne, skin atrophy, bruising, tissue hyperpigmentation, Cushing syndrome.

Stomach ulcer, nausea, vomiting, bloating, esophageal ulcer. pancreatitis. muscle weakness, osteoporosis, fracture, hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Medlon 16 contraindications in the following cases:

Hypersensitivity to methylprednisolon.

Severe infections, except for bacterial shock and meningitis.

Skin damage caused by viruses, fungi or tuberculosis.

is using a living virus vaccine.

Precautions when using

Use cautiously in people with osteoporosis, new blood vessel connection, mental disorders, stomach ulcers, duodenal ulcers, diabetes, hypertension, heart failure and adult children. Due to the risk of unwanted effects, caution must be used with all body corticosteroids for the elderly, with the lowest doses and in the shortest possible time.

Acute adrenal insufficiency may occur when the drug is stopped suddenly after a long time of treatment or when there is stress. When using high doses, it may affect the effects of vaccinations.

The ability to drive and operate machinery

Precautions when using the drug because the drug can cause unwanted effects affecting the ability to drive and operate machinery.

Pregnancy

For extension of body corticosteroids for mothers can lead to mitigation of the babies' weight. Using corticosteroids in pregnant people should consider benefits that can be achieved compared to the risks that may occur with mother and child.

Breastfeeding period

Do not combat corticosteroids for nursing mothers.

Drug interaction

methylprednisolon is a cytochrom P450 enzyme induction and is the substrate of the P450 3A4 enzyme, so this drug affects the metabolism of ciclosporin, erythromycin, phenobarbital, phenytoin, carbamanpin, ketocolazol, ketocoline Rifampicin.

Phenytoin, Phenobarbital, Rifampin and diuretics decreased potassium can reduce the effectiveness of methylprednisolon.

methylprednisolon may cause hyperlemor of blood glucose, so higher insulin dose is needed.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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