Medoclav 1g Medochemie Treatment Treatment of respiratory infections (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxicillin, clavulanic acid

Ingredient

Composition information	Content
Amoxicillin	875mg
Clavulanic Acid	125mg

Uses

indications

Medoclav 1g medicine is indicated for treatment in a short time of the following infections:

Upper respiratory infections: tonsillitis, sinusitis, otitis media have been treated with conventional antibiotics but does not decrease.

Lower respiratory infections by H. Influenzae and Branhamella CatVrbalis producing beta - Lactamase: acute and chronic bronchitis, pneumonia - bronchial.

Severe urinary - genital infections by E. coli, Klebsiella and Enerobacter produce beta - lactamase: cystitis, urethritis, pyelonephritis (female genital tract infection).

Skin infections and soft tissue: pimples, insects, teeth, cell inflammation, wound infections.

Bone and joint infections: Bone inflammation.

Other types of infections: infections caused by miscarriage, bacterial infection, abdominal infections.

Pharmacy

Amoxicillin is a semi-synthetic antibiotic belonging to β-lactam group with wide bactericidal spectrum for many gram-positive and gram-negative bacteria due to synthetic inhibition of bacterial cell walls. But because Amoxicillin is easily destroyed by β-lactamase, therefore does not work for the strains of bacteria that produce these enzymes (multiple strains of Entobacteriaceae and Haemophilus influenza).

Clavulanic acid due to the fermentation of Streptomyces Clavuligerus, with β-lactam structure is similar to penicillin, is capable of inhibiting β-lactamase due to the majority of Gram-negative bacteria and Staphylococcus. Especially, it has a strong inhibition effect of β-lactamase transmitted via plasmid that resists penicillin and cephalosporin.

Pseudomonas Aeruginosa, Proteus Morganii and Rettgeri, some Entobacter and providentia anti -drugs, both anti -methicilin staphylococcus also. Clavulanic acid itself has very weak antibacterial effects.

Clavulanic acid helps amoxicillin not be destroyed by β-lactamase, and expand the antibacterial spectrum of amoxicillin effectively for many common bacteria that have resisted amoxicillin, resistant penicillins and other cephalosporins.

The bactericidal spectrum of the drug includes:

bacteria

strain

Aerobic:

Streptococcus Faecalis, Streptococcus Pneumonia, Streptococcus Pyogenes, Streptococcus Viridians, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes.

anaerobic :

Clostridium, peptococcus, peptostreptoccus species.

Aerobic:

Haemophilus Influenza, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Samonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitides, Vibrio Cholerae, Pasteurella Multocida.

anaerobic:

Bacteroides including B. Fragilis.

Amoxicillin and clavulanic acid are easily absorbed by oral. The concentration of these 2 substances in the serum is maximum after 1-2 hours of taking the medicine. The absorption of the drug is not affected by food and it is best to drink right before meals.

Distribution

both clavulanate and amoxicillin have a ratio of low serum protein (about 25% for clavulanic acid and 18% for amoxicillin). Like other penicillins, amoxicillin can be excreted in breast milk. A very small amount of Clavulanat is also present in breast milk.

Metabolism

Amoxicillin is partially eliminated in the urine in the form of peniciloic acid that is not active with an amount equivalent to 10-25% of the first dose.

Clavulanic acid is converted into 2,3-dihydro-4- acid (2-hydroxyethyl) -5-oxo-1h-1h-pyrroole-3-carboxylic and 1-amino-4-hygry-butan-2-one and eliminated in urine and in the form of carbon dioxide.

Elimination

Similar to other penicillins, the main excretion path of amoxicillin is through the kidneys, while clavulanate eliminates by both paths that are through the kidneys and through the mechanism of the kidneys.

About 60 - 70% amoxicillin and 40 - 65% Clavulanic acid are discharged through urine in the form of unchanged in the first 6 hours after taking a single -dose 250/125mg or 500/125mg.

Concentrated with probenecid extends to eliminate amoxicillin but does not affect the excretion of the kidneys of clavulanic acid.

Before taking Medoclav 1g Medochemie Treatment Treatment of respiratory infections (2 blisters x 7 tablets)

How to use

should take the drug as directed by the doctor. You should not arbitrarily take the drug because this is a prescription drug.

Take medicine at the beginning of eating to minimize the phenomenon of intolerance in the stomach - intestines.

Dosage

Dosage calculated by amoxicillin content in the drug.

Adults and children ≥ 12 years:

Mild and medium infections: 1 tablet (500mg amoxicillin) 12 hours/time.

Severe infections: 1 tablet (500mg amoxicillin) every 8 hours.

Children under 12 years of age: Do not recommend indications for children under 12 years old.

The elderly: No dose adjustment, unless there is kidney failure.

Renal failure: 1g Medoclav tablet is only for patients with mild renal impairment, creatinine clearance greater than 30ml/min.

Hepatic failure: There is no sufficient clinical data for determining the dosage in patients with liver failure. Therefore, if you have liver failure should be cautious when using Medoclav 1g and you should be checked for liver function periodically.

Treatment must not exceed 14 days without examination.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Common overdose symptoms are mainly digestive disorders (including abdominal pain, vomiting and diarrhea) and water and electrolyte imbalance.

A few people have a rash, increase agitation or drowsiness. Interstitial nephritis leading to kidney failure has occurred in a few patients using amoxicillin overdose. Crystal pisses in some cases leading to kidney failure have been reported after the overdose of amoxicillin in adults and children. Kidney damage has recovered. Hypertension can occur in people with kidney function damaged by reducing the elimination of both amoxicillin and clavulanic acid.

Handling

In case you use more than the recommended dose, immediately notify your doctor or go to the nearest medical center for instructions.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using 1G Medoclav medicine, you may experience unwanted effects (ADR).

Very common: diarrhea.

Common: skin and mucouser infection, nausea, vomiting. Nausea often occurs due to high dose orally.

Less: dizziness, headache, indigestion, moderate increase AST and/or alt and alkaline phosphatase in patients treated with Beta - Lactam, foreign, itching, urticaria. dangerous: Reduces with recovery (including neutropen leukopenia) and platelet reduction, diverse erythema.

Very rare: recovery and hemolytic anemia, prolonged bleeding time and prothrombin time, vascular nerve edema, anaphylaxis, serum syndrome, hypersensitivity, hyperactivity with recovery and seizures (convulsions can occur in patients with impaired renal function or in high -dose abutments) )), hepatitis and jaundice have recovery (liver events are recorded mainly in male and elderly patients when taking the drug for a long time, signs and symptoms often occur during the treatment process or in a short time after treatment but in some patients may last up to several weeks after treatment stop treatment), Stevens - Johnson syndrome, acne -scales, bowelitis (AGEP), interstitial nephritis, ureteral stones.

Stop use and report to the doctor immediately if the following reactions occur: allergies such as outside, vasculitis manifested by red or purple spots on the skin, fever, joint pain, swollen neck, armpit or groin, face or mouth causing shortness of breath or any allergic dermatitis.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Medoclav 1g medicine contraindicated in the following cases:

Sensitive to the beta - lactam group (penicillin, cephalosporin).

People with a history of jaundice or liver disorders due to the use of amoxicillin, clavulanate or penicillin.

Be cautious when using

If you are old or have a history of jaundice, liver dysfunction due to amoxicilin and potassium clavulanate, be careful when taking this medication because clavulanic acid causes increased cholestatic risk in the liver.

It is necessary to be especially cautious when taking the drug if you have liver failure or show signs of liver dysfunction. Signs and symptoms of cholestasis jaundice are rarely occurring when taking the drug but may be severe. However, those symptoms are often recovered and will end after 6 weeks of stopping treatment.

If you have kidney failure, notify your doctor to adjust the dose accordingly.

Do not use Medoclav tablets if you have average or severe renal failure.

There has been a report on severe hypersensitivity reactions in patients with a history of penicillin allergy, so before starting treatment with amoxicillin, the doctor needs to notify the doctor if you have a history of allergies to penicillin, cephalosporin and other allergens.

Be cautious for patients with amoxicillin with redness and fever.

Do not take the drug for a long time because it can develop drug -resistant bacteria.

When to consult a doctor, pharmacist?

You need to consult your doctor before using if:

You have a history of jaundice with liver dysfunction due to amoxicillin and potassium clavulanate.

You have liver failure or show signs of liver dysfunction.

You have kidney failure.

affects the ability to drive and operate machinery

There has been no report on the effect of the drug on the ability to operate machinery, train drivers, higher people working and other cases. However, you should avoid doing these jobs if you experience unwanted effects such as dizziness, headache.

Pregnancy and lactation

Pregnancy

Avoid use for pregnant women especially in the first 3 months, except for the necessary case prescribed by the doctor.

Breastfeeding period

During breastfeeding can be used. The drug is not harmful to breastfed children unless there is a risk of sensitivity due to a very small amount of medicine in milk.

Drug interaction

Avoid using Medoclav 1g with the following drugs:

alopurinol;

Anticoagulants;

Oral contraceptives;

Probenecid;

Other antibiotics such as chloramphenicol, macrolid, sulfonamid, and tetracycline.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

Other drugs

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