Medoclav 625mg Medochemie Treatment of infections (4 blisters x 4 tablets)

Dosage form Box of 4 blisters x 4 tablets
Specifications Amoxicillin, clavulanic acid

Ingredient

Composition information	Content
Amoxicillin	500mg
Clavulanic Acid	125mg

Uses

indication

Medoclav 625 drug mg is indicated in the following cases:

Indications for treatment in a short time (less than 14 days) The following cases of infections caused by bacterial strains producing beta - lactamase do not respond to alone amoxicillin treatment:

Heavy respiratory infections: Sinusitis , tonsillitis, otitis media have been treated with conventional antibiotics but does not help. chronic; Pneumonia - Bronchial. injury. Pbps). Amoxicillin is easily destroyed by beta - lactamase, so it does not work for bacterial strains that produce these enzymes.

Clavulanic acid has a beta - lactam structure similar to penicillin, capable of inhibiting beta - lactamase, helping amoxicillin not to be destroyed by beta - lactamase. Clavulanic acid itself has very weak antibacterial effects.

amoxicillin/clavulanic acid is active with bacterial strains including:

Gram -positive aerobic bacteria: Enterococcus Faecalis, Gardnerella Vaginalis, Staphylococcus aureus, Staphylococcus coagulase negative (methicilin sensitive strains), Streptococcus agalactiae, Streptococcus pneumonia, streptococcus pyogenES and streptococc Streptococcus tan tuat beta, Streptococcus Viridans.

Gram -negative aerobic bacteria: Capnocytophaga Bacteroidesfragis, Fusobacterium nucleatum, Prevotella spp.

Amoxicilin and Clavulanat are easy to absorb through oral. The concentration of these 2 substances in the serum is maximum within 1-2 hours after drinking. The absorption of the drug is not affected by food and it is best to drink right before meals.

Distribution

both clavulanate and amoxicillin have a ratio of low serum protein (about 25% for clavulanic acids and 18% for amoxicillin). Like other penicillin, amoxicillin can excrete in breast milk. A very small amount of Clavulanat is also present in breast milk.

Metabolism

Amoxicilin is partially eliminated in the urine in the form of peniciloic acid that is not active in an equivalent amount of 10 - 20% of the first dose.

Elimination

Similar to other penicillin, the main excretion path of amoxicillin is through the kidneys, while clavulanate eliminates by both paths through the kidney and through the renal mechanism.

About 60 - 70% amoxicillin and 40 - 65% Clavulanic acid are eliminated in the urine in the form of constant in the first 6 hours after taking a single dose of 250/125 mg or 500/125 mg.

Simultaneous use of probenecid extends to eliminate amoxicillin but does not affect the excretion of the kidneys of clavulanic acid.

Before taking Medoclav 625mg Medochemie Treatment of infections (4 blisters x 4 tablets)

How to use

Take medicine at the beginning of eating to minimize the phenomenon of non -tolerance in the stomach - intestines.

Do not take medicine for more than 14 days without checking the treatment.

Dosage

Dosage depends on the age, level of renal failure and infection of the patient.

Usually treating infections in adults and children over 12 years old

Smart to medium infections: 1 tablet x 2 times/day.

In cases of severe infections (including urinary and recurrent urinary tract infections): 1 tablet x 3 times/day.

Children under 12 years old

There is no recommendation for children under 12 years old.

Older people

No dose adjustments, unless kidney failure.

Hepatic failure

There is no sufficient clinical data for determining the dosage in patients with liver failure. Therefore, be careful when indicated in these patients and should check the liver function periodically.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Common overdose symptoms

Gastrointestinal disorders (including abdominal pain, vomiting and diarrhea) and water and electrolyte imbalance.

A few people have a rash, increase agitation or drowsiness. Interstitial nephritis leads to kidney failure that occurs in a small number of patients using amoxicillin overdose. Crystal pisses in some cases that lead to kidney failure have been reported after amoxicillin overdose in adults and children. Hypertension can occur in people with kidney function damaged by reducing the elimination of both amoxicillin and clavulanic acid.

Handling

Need to stop the drug immediately. Symptomatic treatment and support if needed.

If an overdose occurs early, it may cause vomiting or gastric lavage without contraindications. Overdose below 250 mg/kg does not cause special symptoms and no need to clean the stomach.

Need to provide enough water and electrolytes to the body to maintain the ureter and reduce the risk of crystal pee.

Can use hemolysis method to remove both amoxicillin and clavulanic acid from circulation.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Medoclav 625 mg, you may experience unwanted effects (ADR).

Common/very common, ADR> 1/100

Bacterial infections: skin and mucosa infection.

digestive: diarrhea, nausea, vomiting.

Uncommon, 1/1000

Neurological: dizziness, headache.

digestion: indigestion.

Mile liver: Moderate increase AST and/or alt and alkaline phosphate.

Skin and soft tissue: rash, itching, urticaria.

rare/very rare, ADR

Hematology: Reducing leukocytes, platelets, recovery granulocytes, hemolytic anemia, prolonged bleeding time and prothrombin.

nerve: hyperactivity with recovery and convulsions. digestive gastrointestinal: fake colitis and bleeding colitis.

Hepatitis: hepatitis, jaundice.

Skin and soft tissue: Diverse roses, Stevens - Johnson syndrome, epidermal necrosis due to poisoning, blistering skin, pustules syndrome (AGEP).

ureter: interstitial nephritis, ureter.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Medoclav 625 mg contraindicated in the following cases:

Hypersensitivity to the beta - lactam group (penicillin and cephalosporin) or any ingredients of the drug.

History of jaundice or liver dysfunction due to penicillin.

Be cautious when using

Pay attention to the elderly, patients with a history of jaundice/liver dysfunction due to the use of amoxicilin and clavulanate acid because clavulanic acid causes increased cholangile risk in the liver.

Needs especially kidneys while used for patients with liver failure or showing signs of liver dysfunction. Signs and symptoms of cholestasis jaundice are rarely occurring when taking the drug but may be severe. However, those symptoms are often recovered and will end after 6 weeks of stopping treatment.

There has been a report on severe hypersensitivity reactions in patients with a history of allergies to penicillin, so before starting amoxicillin treatment, it is necessary to carefully investigate a history of allergies to penicillin, cephalosporin and other allergens.

Pure kidneys for patients using amoxicillin with redness with lymphadenopathy.

Taking drugs for prolonged drugs sometimes develops resistant bacteria.

The ability to drive and operate machinery

There has been no report on the effect of the drug on the ability to operate machinery, train drivers, higher people working and other cases. However, it is recommended that patients should avoid doing these jobs if they experience unwanted effects such as dizziness, headache.

Pregnancy

Experimental research on the process of mice proved when using oral preparations and injected at a dose larger than 10 times the dose for people are not deformed. However, because there is little experience in using preparations for pregnant women, it is necessary to avoid using drugs in pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

The period of breastfeeding

during breastfeeding can be used. The drug is not harmful to breastfed children unless there is a risk of sensitivity due to a very small amount of medicine in milk.

Drug interaction

allopurinol: simultaneous use of amoxicilin with alopurinol will increase the ability of amoxicillin.

Anticoagulant drugs: The drug can cause prolonged bleeding time and prothrombin time. Therefore, it is necessary to be careful for those who are treated with anticoagulants.

Oral contraceptives: Like other broad -spectrum antibiotics, the drug can reduce the effectiveness of oral contraceptives, so it is necessary to notice to the patient and recommend other contraceptive methods.

Probenecid: simultaneously used with probenecid can extend and increase the concentration of amoxicillin in serum due to reduced amoxicillin secretion in the renal tubules.

Other antibiotics: chloramphenicol, macrolid, sulfonamid and tetracycline can reduce the effect of penicillin. However, this only found in in vitro studies, this interaction has not been clinically proven.

Storage

Keep the drug in a closed packaging, temperature below 30 ° C, avoid light.

Other drugs

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