Medskin Clovir 800 DHG medicine treated herpes simplex virus, chickenpox, shingles pneumonia (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Acyclovir

Ingredient

Composition information	Content
Acyclovir	800mg

Uses

indications

Medskylovir 800 drugs are indicated in the following cases:

Indications for treating chickenpox and herpes zoster (shingles) (excluding newborn HSVs and severe HSV infections in children with immunodeficiency). Next, the inhibitor in reverse transcription of nucleosid and nucleotid.

ATC code: J05ABO1.

Acyclovir is a synthetic purin nucleosid derivative, inhibited inhibitor and in vivo in humans, including herpes simplex virus (HSV) Type I and Type II and Varicella Zoster virus (VZV).

Acyclovir inhibition activity for HSV I and HSV II and VZV is highly selective. Thymidin kinase enzymes (TK) of normal (non -viral) cells do not use acyclovir as a substrate, so toxicity to the host cell of mammals is low; However, the account is encrypted by HSV and VZV to convert acyclovir into acyclovir monophosphate, a nucleoside conductor, then converted to Diphosphate and finally into Triphosphate by cell enzymes. Acyclovir Triphosphate interferes with the virus's DNA polymerase and inhibits the copy of the virus DNA, binds to the virus DNA and ends the DNA chain.

Using prolonged or repeated Acyclovir in patients with severe immunodeficiency can lead to reduced sensitivity of virus strains, and no longer responding to acyclovir treatment. In clinical, most strains reduced the sensitivity to acyclovir due to the lack of enzyme TK, however, the strains with the transformed TK enzyme or DNA polymerase have been reported. In Vitro, the contact of HSV isolated with Acyclovir can also lead to the appearance of less sensitive strains. The relationship between in vitro sensitivity of HSV strains and clinical response to Acyclovir is unclear.

Dynamic pharmacokinetics

absorption

Acyclovir is partially absorbed from the intestine. The average oral biology varies from 10 to 20%. In hunger conditions, the average peak concentration (CMAX) is 0.4 micrograms/ml achieved after about 1.6 hours when using 200 mg dose in the form of oral or oral fluid. The average peak concentration in plasma (CSSMAX) increased to 0.7 micrograms/ml (3.1 micromoles) in a stable state after the dose of 200 mg, four hours once. The rise at a lesser rate is observed for CSSMAX concentrations after using a dose of 400 mg and 800 mg, every four hours, with values, respectively 1.2 and 1.8 micrograms/ml (5.3 and 8 micromoles).

distribution

The average distribution volume is 26 l showing that Acyclovir is distributed in the total amount of body water. After oral, the distribution of the drug (VD/F) ranges from 2.3 to 17.8 l/kg. Because the cohesion with plasma protein is relatively low (9 to 33%), drug interactions associated with the unpredictable cohesive position transfer. The concentration of medication in cerebrospinal fluid is approximately 50% of the corresponding plasma concentration in a stable state.

transformation

Acyclovir is excreted mainly in the form of renal. The only important metabolic substance in urine is 9 - [(carboxymethoxy) Methyl] Guanin, and accounts for 10-15% of the dosage of excretion through the urine.

Elimination: In adults, the concentration of systemic drugs (AUC0 -∞) is in the range of 1.9 to 2.2 micrograms * H/ml after taking the dose of 200 mg. At this dose, the average semi -discharged time after oral drink varies from 2.8 to 4.1 hours.

Acyclovir's kidney clearance (Clr = 14.3 l/h) is much larger than the creatinine clearance, showing the excretion of the renal tubules, in addition to the filtering function in the glomerular, contributing to the elimination of the drug through the kidney. The disposal time and the total clearance of acyclovir depend on the kidney function. Therefore, the recommendation of adjusting the dose for patients with renal failure.

There is no pharmacokinetic data for babies. The existing pharmacokinetic data is available for intravenous preparations in this age group.

Special subjects

Elderly: In elderly patients with normal renal function, the total clearance of age is reduced when age is higher due to reduced creatinine clearance. However, it is necessary to consider the possibility of renal failure in the elderly and adjust the dose accordingly.

Renal failure: In patients with chronic renal failure, the average selling time is 19.5 hours. The average selling time of acyclovir during hemorrhage is 5.7 hours. Acyclovir concentration in plasma decreased by about 60% during dialysis.

Before taking Medskin Clovir 800 DHG medicine treated herpes simplex virus, chickenpox, shingles pneumonia (3 blisters x 10 tablets)

How to use

oral tablets.

Can be dispersed in at least 50 ml of water or swallow all with a little water.

Make sure the patient uses high doses of Acyclovir, so it is enough water.

or as directed by the physician.

Dosage

Dosage in adults

Treatment of chickenpox and shingles: 800 mg x 5 times/day, about 4 hours apart, skip the night. Should be treated for 7 days.

In patients with serious immunodeficiency (for example after marrow transplantation) or in patients with impaired absorption from the intestine, should consider taking drugs by vein.

Should be treated early at the beginning of the infection: Shingles treatment with better results should start as soon as the rash is onset. Treatment of chickenpox in patients with immunodeficiency should start within 24 hours after the rash.

Dosage for children

Chickenpox treatment

Children 6 years and older: 800 mg x 4 times/day. Should be treated for 5 days.

There is no specific data on shingles treatment in children with immunity.

To treat the herpes virus infection in infants, abortic acyclovir should be used.

Dosage for the elderly

Must consider the possibility of kidney failure in the elderly and adjust the dose accordingly.

Elderly patients with high doses of Acyclovir should drink enough water.

Dosage for people with renal failure

Be cautious when taking acyclovir for patients with impaired renal function. Should maintain enough water.

In the treatment of shingles infection, adjust the dose to: 800 mg x 2 times/day, about 12 hours apart for patients with severe renal impairment (creatinine clearance

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Patients with overdose up to 20 g of acyclovir only once, usually no harmful effects. Overdose of Acyclovir repeated for a few days will appear effects on the digestive tract (such as nausea, vomiting) and nervous system (headache, confusion).

How to handle: Patients should be closely monitored by signs of poisoning. The hemorrhage appraisal enhances the removal of acyclovir from the blood and therefore can be considered as an option to handle symptoms overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Medsklovir 800, you may experience unwanted effects (ADR).

The unwanted effects under the frequency below are estimated. For most unwanted effects, appropriate data to estimate the incidence of the disease is not available. In addition, unwanted effects may vary in proportions depending on indications. The following convention is used to classify unwanted effects on frequency: very common ≥ 1/10, common ≥ 1/100 and

Blood disorders and lymphatic systems

Very rare: Anemia, leukopenia, thrombocytopenia.

immune system disorders

Rare: Anaphylaxis.

Mental and nervous disorders

Common: headache, dizziness. Very rare: agitation, confusion, tremor, loss of air conditioning, arrhythmia, hallucinations, psychotic symptoms, convulsions, drowsiness, brain disease, coma.

respiratory disorders, chest and mediastinum

Rare: Difficulty breathing.

Digestive disorders

Common: Nausea, vomiting, diarrhea, abdominal pain.

Rare: Increased bilirubin recovery and liver enzymes.

Very rare: hepatitis, jaundice.

Common: itching, rash (including light sensitivity).

Not common: urticaria. Disseminated hair loss. Dissemated hair loss is related to many diseases and drugs, not sure by Acyclovir.

Rare: Feduna.

Rare: increased urea and blood creatinine.

is very rare: Acute renal failure, kidney pain. Kidney pain may be associated with kidney failure and crystal in urine.

Common: fatigue, fever.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Medsmlovir 800 drug contraindicated in the following cases:

Hypersensitivity to acyclovir or valacyclovir, or any excipients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Used for patients with renal failure and elderly patients

Acyclovir is eliminated through the renal clearance, so the dose adjustments must be adjusted in patients with renal impairment. Elderly patients are likely to have renal function and therefore need to adjust the dose in this group of patients. Elderly patients and patients with renal impairment have high risks of mental side effects and should be closely monitored the effects of these side effects. In the reported cases, these side effects will end when the drug is stopped. Acyclovir treatment is prolonged or repeated on patients with severe immunodeficiency, which can lead to reduced sensitivity of virus strains, and no longer respond to acyclovir treatment.

Water compensation status: Need to pay attention to adequate water for patients with high doses of Acyclovir.

The risk of renal failure increases when used with poison with other kidneys.

The existing data from clinical studies is not enough to conclude that Acyclovir treatment reduces the rate of chickenpox -related complications in immunodeficiency patients.

Related to excipients

The starch in this drug contains only very low gluten content and is less likely to be harmful if the patient has a celiac disease. If allergic to wheat, patients should not use this medication.

red ponaceau: can cause allergic reactions.

The ability to drive and operate machinery

There has been no research on the influence of Acyclovir on driving or operating machinery. The disadvantage of such activities cannot be predicted from the pharmacological pharmacology of the active ingredient, but it should be paid attention to the unwanted effects.

used for pregnant and lactating women

Pregnant women

should only use Acyclovir when benefits are higher than risk.

The post -marketing data in pregnant women using Acyclovir (any form) indicates that there is no increase in the number of birth defects between objects in contact with Acyclovir compared to other subjects. Using all -body acyclovir in internationally accepted standard tests does not show toxic effects on embryos or teratogenicity in rabbits, rats or mice.

In a non -standard test on mice, fetal abnormalities are observed but only after high doses under the skin to toxic to the mother. The clinical relevance of these findings is uncertain.

Be cautious by balancing the potential benefits of treatment and any risk that may occur.

breastfeeding women

After taking 200 mg of acyclovir x 5 times/ day, Acyclovir was discovered in breast milk with a concentration of 0.6 to 4.1 times compared to the corresponding concentration in plasma. This level can cause breastfeeding to contact with acyclovir dosage up to 0.3 mg/ kg/ day. Therefore, be careful if you use medication for breastfeeding women.

fertility

There is no information about the effect of acyclovir on women's fertility.

In a study of 20 male patients with normal sperm, the oral acyclovir used at a dose of up to 1 g per day within 6 months has been shown to have a significant clinical impact on the number, movement or morphology of sperm.

Drug interaction

Acyclovir is eliminated mainly in the form of constant urine, through the excretion process in the renal tubules.

Any drug used simultaneously competes with this mechanism can cause increased acyclovir levels in plasma. Probenecid and cimetidine increases the area under the curve (AUC) of acyclovir under this mechanism, and reduces the kidney clearance of acyclovir.

Similarly, Acyclovir's AUC growth and inactive metabolites of Mycophenolat Mofetil (an immunodeficiency agent for implant patients) have been noticed when the drugs are used simultaneously.

However, there is no need to adjust the dose because Acyclovir has a wide treatment index.

A test study on 5 men shows that simultaneously used with acyclovir increases the AUC of theophylin about 50%. Should determine the content in plasma when treated simultaneously with acyclovir.

Storage

In a dry place, the temperature does not exceed 30 ° C.

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