Mefenamic Acid Stella 500mg treat headaches, toothache, osteoarthritis (100 tablets)

Dosage form Box of 100 capsules
Specifications Mefenamic Acid

Ingredient

Composition information	Content
Mefenamic Acid	500mg

Uses

indications

Mefenamic Acid Stella 500mg is indicated in the following cases:

Reduce symptoms from mild to medium pain in headache, toothache, postoperic pain, postpartum pain, dysmenorrhea.

Disorders of skeletal and joints such as arthritis, rheumatoid arthritis.

Menstrual wisdom.

Pharmacokology

Mefenamic Acid is a nonsteroidal anti -inflammatory drug (NSAID) that has anti -inflammatory, analgesic and antipyretic effect. Prostaglandin are related to a number of processes including inflammation, adjustment to response to pain, dysmenorrhea, menstrual period and fever. Like other NSAIDs, Mefenamic acid inhibits prostaglandin synthesis (inhibit cyclooxygenase). This inhibition reduces the speed of prostaglandin and reduces the concentration of prostaglandin.

pharmacokinetics

absorption:

Mefenamic Acid is absorbed through the gastrointestinal tract. The peak concentration in plasma is about 2-4 hours after taking the drug.

Distribution:

more than 90% of Mefenamic acid associated with plasma proteins. The drug is distributed into breast milk.

Metabolism:

Mefenamic Acid is metabolized by isenzyme CYP2C9 of the Cytochrom P450 system into 3-hydroxymethyl mefenamic acid, which can then be oxidized into 3-carboxymefenamic acid.

Era:

Over 50% of the dose is found in urine in a constant form or mainly the combined form of Mefenamie Acid and its metabolites.

Sell waste time in plasma from 2 - 4 hours.

Before taking Mefenamic Acid Stella 500mg treat headaches, toothache, osteoarthritis (100 tablets)

How to use

Take oral use.

Take medicine at meals or after meals.

Dosage

Do not take medicine for more than 7 days to treat mild to moderate pain.

Adults: 500mg x 3 times/day.

Children aged 12-18 years old, dysmenorrhea, menorrhagia: 500mg x 3 times/day.

Do not take medicine for children under 12 years old.

or according to the doctor's instructions.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Symptoms include headache, sadness, epigastric pain due to vomiting, gastrointestinal hemorrhage, rare diarrhea, disorientation, agitation, coma, drowsiness, buzzing, fainting, sometimes convulsions (Mefenamic Acid often stimulates spastic seizures when overdose). In case of severe poisoning, acute renal failure and liver injury may occur.

Treatment:

Patients need to treat symptoms as required. Use activated carbon for an hour after overdose. In addition, in adults, should choose the measure of gastrointestinals within an hour after taking the dose that is likely to cause life -threatening. Patients should be closely monitored for at least 4 hours after the dose is at risk of poisoning. Hemorrhage is less effective because Mefenamic Acid and its metabolites are closely linked to plasma proteins. However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Mefenamic Acid Stella 500mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100:

Digestive: diarrhea, fecal fat recovery, colitis.

Not determined

Bloody disorders and lymphatic systems: Hemolytic anemia (can recover when stopping using mefenamic acid), anemia, hematocritis, hematocrit decrease, hemorrhage due to thrombocytopenia, temporary reduction of leukocytes (leukopenia) with the risk of bacterial infections, infections, blood coagulation scattered inner vascular. Seed leukemia, anemia anemia, eosinophilia loves EOSIN, neutral leukocytes, reducing all bloody, platelets.

Immune system disorders: There have been sensitive reactions after treatment with NSAID drugs. These reactions may include non -specific allergic reactions and the hypersensitivity reactions in the respiratory tract including asthma, bronchospasm, shortness of breath or various skin disorders such as rashes, itching, urticaria, hemorrhage, vein, rare skin peeling or blistering (including epidermal necrosis and diverse roses).

Metabolic and nutritious disorders: Glucose intolerance in diabetics, hypoglycemia.

Mental disorders: Confusion, depression, hallucinations, restlessness.

Nervous system disorders: optic neuritis, headache, abnormalities, dizziness, drowsiness, cases of sterile meningitis (especially for patients with autoimmune disorders such as systemic lupus, mixed tissue disease), with symptoms such as stiff neck, headache, nausea, vomiting, fever, fever, inferiority.

Eye disorders: eye irritation, loss of ability to see color recovery, visual disorders.

Ear and inner ear disorders: ear pain, tinnitus, dizziness.

Heart/vessel disorders: edema, hypertension and heart failure are reported related to the use of NSAIDs.

Affect the kidneys: There is a report on acute renal failure not decreased in the elderly patients using Mefenamic acid to treat muscle pain.

Pancreatitis: There is a report on pancreatitis related to Mefenamic acid.

Porphyria metabolic disorders: Mefenamic acid is said to be unsafe when used for patients with Porphyria metabolic disorders despite the contradictory experimental evidence of urination of porphyrin.

Mefenamic acid can cause false positive in some honey salt tests in urine.

Risk of cardiovascular thrombosis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Mefenamic acid drugs are contraindicated in the following cases:

Hypersensitivity to Mefenamic acid or any ingredients of the drug;

intestinal inflammation;

Having a history of hemorrhage or gastrointestinal perforation is related to the treatment of nonsteroidal anti -inflammatory drugs;

There is a history or periodic gastrointestinal bleeding/gastrointestinal bleeding (there are 2 or more than 2 ulcers or gastrointestinal bleeding);

heart failure, liver failure, severe kidney failure;

Because Mefenamic acid is at risk of cross -sensitive with aspirin, ibuprofen, or other non -steroid anti -inflammatory drugs, it is not recommended for patients with a history of hypersensitivity to these drugs (such as asthma, bronchitis, rhinitis, angiight, urticaria);

Women who are pregnant in the last quarter;

Treatment of pain after coronary graft surgery.

Caution when using

Patients with dehydration or kidney disease, especially the elderly.

Elderly: Elderly people have the frequency of increasing side effects with NSAID drugs, especially hemorrhage and puncture of the digestive tract may die.

Respiratory disorders: Patients who are or have had bronchial asthma.

Cardiovascular disease, liver failure and kidney failure: NSAID medication can lead to a decrease in prostaglandin that depends on the dose and accelerate the process of renal failure. Patients with renal function, heart failure, liver failure, diuretic users and the elderly are the highest risks with this reaction.

Effects on cardiovascular, cerebral vessels: For patients with a history of hypertension and/or mild to moderate congestion such as fluid fluid, edema when using NSAID drugs should be monitored and appropriate instructions.

Hemorrhage, ulcers and gastrointestinal puncture: Hemorrhage, ulcers or gastrointestinal perforation may occur at any time during the treatment process, with or without warning symptoms or a history of serious gastrointestinal diseases. Smoking and drinking can increase these risk factors.

Systemic lupus and mixed tissue luplia: Patients with systemic erythematosus lupus (SLE) and mixed connective tissue disorders may have a high risk of sterile meningitis.

Skin reactions: Serious skin reactions, some fatal reactions, including scaled dermatitis, Stevens-Johnson syndrome, epidermal necrosis due to poisoning are thought to be related to the use of NSAID drugs. Patients often have the highest risk of these reactions in the early stages of treatment, the initial reaction occurs in most cases in the first month of the treatment process. Stop using mefenamic acid as soon as the skin rash appears, mucosal damage or any other hypersensitivity signs.

Reproductive ability in women: using Mefenamic acid can impair fertility in women.

Epilepsy: Be careful when using the drug for patients with epilepsy.

Need to monitor blood formula, liver, kidney function when using mefenamic acid for a long time.

Risk of cardiovascular thrombosis: nonsteroidal anti -inflammatory drugs (NSAIDs), non -aspirin, using systemic tract, may increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient does not have previous cardiovascular symptoms. Patients should be warned of symptoms of serious cardiovascular events and need to visit the doctor as soon as they appear.

To minimize the risk of adverse events, Mefenamic Acid 500mg is needed at the lowest daily dosage in the shortest possible time.

The ability to drive and operate machinery

Unwanted effects such as dizziness, drowsiness, fatigue, visual disorders that can occur when using NSAID. If affected, patients should not drive or operate machinery.

Pregnancy

Birth defects are thought to be related to the use of nsAID drugs in humans; However, these defects have low frequency and no clear pattern. From the viewpoint of the known effects of NSAID drugs on the fetal cardiovascular system (risk of arteriosclerosis), contraindicated drug use in the last quarter of pregnancy. Labor is slowed down, prolonged labor time and is at risk of hemorrhage in both mother and child. NSAID drugs should not be used in the first two quarters of pregnancy or during labor unless the benefits of the drug for the mother are higher than the risk of the fetus.

Lactation period

Mefenamic acid is distributed into breast milk. Due to the risk of side effects of the cardiovascular system in the newborn, it is necessary to decide to stop breastfeeding or stop the drug, consider the importance of the drug for the mother.

Drug interaction

need to adjust the dose when treated simultaneously with other plasma protein -connected drugs.

Anticoneal drugs: NSAID drugs can increase the effects of anticoagulants like warfarin. When used simultaneously with oral anticoagulants need to closely monitor prothrombin time.

Lithi: Reduce lithium clearance in the kidney and increase plasma lithium concentration. Patients should be closely monitored by signs of lithium poisoning.

Other painkillers include selective Australian medications Cycloxygenase-2: Avoid using two or more NSAID drugs (next to aspirin) because it can increase the risk of unwanted effects.

Antidepressants: Selective drugs recover serotonin (SSRIs): Increases the risk of gastrointestinal bleeding.

Treatment of hypertension and diuretics: Reduce anti -hypertension and diuretic effects. Tieu gums can increase the risk of kidney poisoning of NSAID drugs.

Angiotensin II transferred and receptor -resistant enzyme inhibitors: reduce anti -hypertension effects and increase the risk of kidney failure, especially in elderly patients. Patients must be adequate water supply and kidney function assessment at the beginning and during simultaneous treatment.

aminoglycosides: Reduce kidney function in patients with kidney disease, reduce aminoglycosides and increase plasma concentrations.

Anti -thrombocytopenic drugs: Increases the risk of ulcer or gastrointestinal bleeding.

cardiac glycosides: NSAIDs can increase heart failure to reduce glomerular filtration rate and increase cardiac glycosides in plasma.

ciclosporin: NSAIDs can increase the risk of ciclosporin's kidney toxicity.

corticosteroid: increases the risk of bleeding or gastrointestinal ulcer.

Oral hypoglycemic drugs: inhibit the chemicals of sulfonylure drugs, prolong the sale time and increase the risk of hypoglycemia.

Methotrexate: The elimination of drugs can decrease, increasing the concentration of drugs in plasma.

Mifepriston: No background use of NSAIDs after using Mifepriston 8 - 12 days because NSAID can reduce the effect of Mifepriston.

Probenecid: Reducing the chemistry and elimination of NSAIDs and chemical substances.

Quinolon antibiotics: Patients who take NSAID and Quinolon can increase the risk of progressive seizures.

tacrolimus: When using simultaneously Tacrolimus with NSAIDs can increase the risk of toxicity on the kidneys.

Zidovudin: When using simultaneously zidovudin with NSAIDs can increase the risk of hematology.

The cavalry of the drug:

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

In a dry place, avoid light, temperatures below 30 ° C.

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