Mekocefaclor 500mg Mekophar Treatment of infections (2 blisters x 8 tablets)

Dosage form Box of 2 blisters x 8 tablets
Specifications Cefaclor

Ingredient

Composition information	Content
Cefaclor	500mg

Uses

indications

Mekocefaclor 500 mg is indicated for the treatment of infections caused by sensitive bacteria strains:

acute sinusitis . Haemophilus Influenzae, and Streptococcus Pyogenes; chronic bronchitis .

Sore throat, tonsillitis , caused by streptococcus pyogenes.

Note: Penicilin is a regular choice in the treatment and prevention of streptococcus infections, including the prophylaxis of rheumatism. Cefaclor often works in the elimination of streptococcus from the nose, however, the data significantly determines the effectiveness of Cefaclor in the prevention of rheumatism is not available.

Urinary tract infections, including nephritis - pyelonephritis, cystitis, caused by Escherichia Coli, Proteus Mirabilis, Klebsiella spp., and Staphylococcus coagulase negative. Pyogenes. Sensitive bacteria. When culture information and sensitivity exist, they should be considered in choosing or changing antibacterial therapy. Without this information, local epidemiology or sensitive models can contribute to the selection of antibacterial therapy.

cefaclor is an oral, semi -synthetic cephalosporin antibiotic, 2nd generation, has the effect of killing bacteria growing and dividing by inhibiting synthesis of bacterial cells.

The following strains of bacteria are sensitive to cefaclor:

Aerobic bacteria, Gram -positive: Staphylococcus, including the enzyme formation strain, positive coagulase, negative coagulase, streptococcus pneumoniae, streptococcus pyogenes.

Aerobic bacteria, Gram negative: Escherichia coli, Haemophilus influenzae (including B-Lactamase enzyme formation, ampicillin resistance), Klebsiella spp., Neisseria Gonorrhoeae, Proteus Mirabilis.

Anaerobic bacteria: bacteroides spp. (Except for Bacteroides Fragilis), Peptococcus Niger, peptostreptoccccus spp.

Dynamic pharmacokinetics

absorption

Cefaclor is well absorbed after drinking. With a dose of 250 mg and 500 mg of tablets for hunger, the average peak concentration in plasma is about 7 and 13 micrograms/ml, achieved after 30 to 60 minutes. The sale time of cefaclor in plasma is from 30 to 60 minutes. About 25% Cefaclor binds to plasma proteins.

Distribution

Cefaclor is widely distributed throughout the body, passes through the placenta and excreted in low concentrations.

Elimination

Cefaclor quickly excreted through the kidneys, up to 85% of the use is eliminated through the urine in the form of unchanged within 8 hours, most of the excretion in the first 2 hours in people with normal renal function. A little cefaclor is excreted through hemorrhage.

Before taking Mekocefaclor 500mg Mekophar Treatment of infections (2 blisters x 8 tablets)

How to use

oral medication.

Dosage

Dosage

Adults

Common dose used 250 mg, every 8 hours/time. For cases of severe infections (pneumonia) or caused by less sensitive bacteria, doses may be double: taking 500 mg, every 8 hours. Maximum 4 g/day.

Children

The common dose uses 20 mg/kg/day, every 8 hours. In more serious bacterial infections, otitis media, and bacterial infections that are caused by less sensitive bacteria, 40 mg/kg/day can be used, maximum dose of 1 g/day.

Patients with impaired renal function

Cefaclor can be used for patients with impaired renal function, treatment dose is usually not changed.

Patients must have regular hemolysis

Starting dose from 250 - 1000 mg before absorbing blood apart and maintaining treatment dose 250 - 500mg, every 6 - 8 hours, during the time between the fertilizer.

Elderly

Dosage is like adults.

In the treatment of Beta blood -soluble streptococci infection

Cefaclor's treatment should be used for at least 10 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Nausea, vomiting, epigastric pain and diarrhea.

How to handle

There is no specific antidote, symptomatic treatment and supportive measures.

No need to wash the stomach, intestines, unless you have taken Cefaclor at a dose of 5 times the normal dose.

Protect the respiratory tract for patients, support ventilation and infusion.

Reduce the absorption of drugs by giving activated carbon many times.

Actively monitor for timely treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Mekocefaclor 500 mg , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Blood: Eosin hypernagus.

digestive: diarrhea.

Skin: Fiber leather.

Uncommon, 1/1000

Blood: increased lymphocytes, leukopenia, neutropenia.

digestion: Nausea, vomiting.

Systemic: Test Coombs directly positive. skin: itching, urticaria. Urinary - genital: Itchy genitals, vaginitis, Candida fungus .

Rare, 1/10,000

Systemic body: Anaphylaxis, fever, symptoms like serum (common with children under 6 years old), Stevens-Johnson syndrome, poisoned epidermal necrosis (Lyell syndrome), body acne skin rash.

The serum is more common in children than adults: diverse rash, inflammation or joint pain, fever or no, may be accompanied by large lymph nodes, proteinuria.

blood: thrombocytopenia, hemolytic anemia.

digestive: fake colitis . liver: Increased liver enzyme (asat, alat, alkaline phosphatase), hepatitis and jaundice. kidney: interstitial nephritis, slight increase in blood urea or serum creatinine or abnormal urine tests.

Central nervous system: seizures (with high doses and impaired renal function), increased excitement, headache, restlessness, insomnia, confusion, tone, dizziness, hallucinations and sleep.

Instructions on how to handle ADR

Stop using Cefaclor if allergies occur. Hypersensitivity symptoms may persist for a few months. In the case of allergies or serious hypersensitivity reactions, it is necessary to conduct supportive treatment (maintenance of ventilation, oxygen breathing, adrenalin use, corticosteroid intravenous injection).

If convulsions are treated by medication, it is necessary to stop the drug. Can be treated with anti -convulsions if necessary.

Stop treatment if there is severe diarrhea. Cases of false colitis due to Clostridium developing too mild, usually just stop the drug. Medium and severe cases should pay attention to the transmission of epidemics and electrolytes, protein supplements and antibiotic treatments on Clostridium difficile effect (should use metronidazol, do not use vancomycin). Serum -like reactions usually occur a few days after the beginning of treatment and weight loss after stopping the drug a few days. Sometimes severe reactions need to be treated with antihistamines and Costicosteroids.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Mekocefaclor 500 mg contraindicated in the following cases:

Hypersensitivity to cefaclor and other antibiotics belonging to the cephalosporin, penicillin, or any ingredient of the drug.

Be cautious when used

cefaclor for long -term use can cause fake colitis caused by Clostridium difficile. Precautions for patients with a history of gastrointestinal tract, especially colitis. It is necessary to suspect fake colitis when prolonged diarrhea appears, bloody stools in patients are taking or within two months after using antibiotic therapy.

Be careful when using Cefaclor for people with severe renal function. Because the selling time of Cefaclor in patients with anaturia is 2.3 - 2.8 hours (compared to 0.6 - 0.9 hours in normal people), often do not need to adjust the dose for people with average renal insufficiency but must reduce the dose in severe renal failure. Kidney function should be monitored during cefaclor treatment in combination with antibiotics that have the potential toxic to the kidneys (such as aminosid antibiotic groups) or with Furosemid, ethacrynic acid.

Find the urinary glucose with false reducing agents. The false positive reaction will not occur if the specific detection method is used with glucose oxidase.

Safety and effectiveness of Cefaclor capsules and Cefaclor oral discharge for children under 1 month of age have not been set. The safety and effectiveness of long -lasting release tablets Cefaclor for children under 16 have not been set up.

Test Coombs positive during cefaclor treatment. While making blood transfusions or testing Coombs test in infants whose mothers used cefaclor before birth, this reaction may be positive for drugs.

The ability to drive and operate machinery

The drug can cause chicken sleep, dizziness, hallucinations, ... can affect the ability to operate machinery, train driving, higher people working and other cases. Caution should be used for those who operate machinery, train trains, higher people and other cases.

Pregnancy

Cephalosporin antibiotics are often considered safe when used for pregnant women. However, because no project has been fully studied in pregnant women, Cefaclor is only designated in pregnant women when really necessary.

The period of breastfeeding

Cefaclor concentration in breast milk is very low (0.16 - 0.21 microgram/ml after the mother takes a single dose of 500 mg). The impact of the drug on breastfeeding is unknown but should be careful. Trong when the child has diarrhea, wasting and rash. Should consider stopping breastfeeding during the time the mother took the drug.

Medicinal interaction

simultaneously used with warfarin rarely increases prothrombin time, causing bleeding. For these patients, regular prothrombin should be monitored and adjust the dose when necessary.

Probenecid increases the concentration of cefaclor in serum.

Concentrated with aminoglycosid antibiotics or Furosemid diuretics increases the toxicity of the kidneys.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

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